推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
mp
166.2-168.2 °C (lit.)
溶解性
DMSO: >10 mg/mL
H2O: insoluble
创始人
Kissei
储存温度
2-8°C
SMILES字符串
COc1ccc(\C=C\C(=O)Nc2ccccc2C(O)=O)cc1OC
InChI
1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
相关类别
应用
在小鼠骨髓来源的肥大细胞中研究了曲尼司特对肥大细胞表面受体的作用。[1]
生化/生理作用
曲尼司特是一种抗哮喘药物,可抑制刺激单核细胞 LTC 4 和 PGE 2 的形成,但不抑制环氧合酶或脂氧合酶活性;抑制肥大细胞脱颗粒;在体内抑制 VEGF 诱导的血管生成 ,在体外也抑制人内皮细胞的增殖和管道形成 。曲尼司特可能代表一类新的治疗 T H 1 介导的自身免疫性疾病的药物。
曲尼司特是一种抗哮喘药物,抑制刺激的单核细胞 LTC 4 和 PGE 2 的形成,抑制肥大细胞脱颗粒,并抑制体内 VEGF 诱导的血管生成,也抑制体外人内皮细胞的增殖和成管。
警示用语:
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Philippe Lachapelle et al.
Pharmacology & therapeutics, 187, 98-113 (2018-02-21)
The transforming growth factor (TGF)-β cytokines play a central role in development and progression of chronic respiratory diseases. TGF-β overexpression in chronic inflammation, remodeling, fibrotic process and susceptibility to viral infection is established in the most prevalent chronic respiratory diseases
Tranilast inhibits cardiac allograft vasculopathy in association with p21waf1/cip1 expression on neointimal cells in murine cardiac transplantation model
Izawa A, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 21(7), 1172-1178 (2001)
Emiri Tarbit et al.
Heart failure reviews, 24(1), 1-15 (2018-07-11)
Experimental research has recognized the importance of cardiac fibroblast and myofibroblast cells in heart repair and function. In a normal healthy heart, the cardiac fibroblast plays a central role in the structural, electrical, and chemical aspects within the heart. Interestingly
Noriaki Minami et al.
Cancer medicine, 6(11), 2635-2645 (2017-10-06)
Therapeutic options for malignant brain tumors are limited, with new drugs being continuously evaluated. Organotypic brain slice culture has been adopted for neuroscience studies as a system that preserves brain architecture, cellular function, and the vascular network. However, the suitability
Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells
Harigai R, et al.
Scientific reports, 8(1), 6069-6069 (2018)
商品
Discover Bioactive Small Molecules for Lipid Signaling Research
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持