T0682
牛磺猪去氧胆酸钠 水合物
≥98%
别名:
牛磺猪去氧胆酸 钠盐 水合物
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关于此项目
线性分子式:
C26H44NO6SNa · xH2O
化学文摘社编号:
分子量:
521.69 (anhydrous basis)
MDL编号:
UNSPSC代码:
12161900
PubChem化学物质编号:
NACRES:
NA.25
描述
anionic
质量水平
方案
≥98%
分子量
521.69 g/mol (anhydrous basis)
应用
detection
SMILES字符串
O.[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI
1S/C26H45NO6S.Na.H2O/c1-16(4-7-24(30)27-12-13-34(31,32)33)19-5-6-20-18-15-23(29)22-14-17(28)8-10-26(22,3)21(18)9-11-25(19,20)2;;/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);;1H2/q;+1;/p-1/t16-,17-,18+,19-,20+,21+,22+,23+,25-,26-;;/m1../s1
InChI key
MJKUJELEPWZEGU-IGEKTTBWSA-M
一般描述
牛磺猪去氧胆酸钠水合物是牛磺酸酰胺化胆盐，可作为阴离子洗涤剂。
应用
牛磺猪去氧胆酸钠水合物已用于一项研究，以评估呋喃处理大鼠肝脏中细胞毒性、再生性细胞增殖和继发性氧化 DNA 损伤的剂量响应数据。 它也被用于一项研究，以探讨使用固定化人工膜 HPLC 柱预测胆盐-膜相互作用。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
M De Bernardi di Valserra et al.
Arzneimittel-Forschung, 43(8), 880-887 (1993-08-01)
Fifty-two-week oral toxicity and 24-week intraperitoneal toxicity of a new synthetized biliary acid, taurohyodeoxycholic acid (Io, Praxis, CAS 2958-04-5), were investigated in rats. Taurohyodeoxycholic acid was orally administered at dose levels up to 500 mg/kg/d and intraperitoneally administered at dose
C Song et al.
Steroids, 65(8), 423-427 (2000-08-11)
We have found that certain natural 6alpha-hydroxylated bile acids are receptor-specific activators of nuclear liver X receptor alpha (LXRalpha) (NR1H3), a nuclear receptor regulating the expression of the cholesterol 7alpha-hydroxylase gene, coding for the rate-limiting enzyme in the major pathway
Leonardo Baiocchi et al.
Journal of hepatology, 38(2), 136-147 (2003-01-28)
Taurohyodeoxycholate (THDCA) and tauroursodeoxycholate (TUDCA) induce more bile flow per molecule excreted compared to endogenous bile acids. The aim of this study is to determine if the hypercholeretic effect of tauroursodeoxycholate or taurohyodeoxycholate in normal and bile duct ligated (BDL)
M Paolini et al.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 48(1), 49-59 (2000-03-01)
To clarify the preventive effect of taurohyodeoxycholic acid on liver cholestasis induced by toxic bile acids in rats, we evaluated whether modulation of cytochrome P4503A-linked oxidases is involved in the hepatic bile acid retention and secretion mechanism. We investigated whether
Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the rat.
A Roda et al.
Hepatology (Baltimore, Md.), 27(2), 520-525 (1998-02-14)
The prevention of the hepatotoxic effects produced by intravenous infusion of taurochenodeoxycholic acid (TCDCA) by coinfusion with taurohyodeoxycholic acid (THDCA) was evaluated in bile fistula rats; the hepatoprotective effects of the latter were also compared with those of tauroursodeoxycholic acid
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