T0825
Anti-Transportin 1 antibody, Mouse monoclonal
clone D45, purified from hybridoma cell culture
别名:
Anti-IPO2, Anti-KPNB2, Anti-MIP, Anti-MIP1, Anti-TRN
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关于此项目
Conjugate:
unconjugated
Clone:
D45, monoclonal
Application:
immunocytochemistry
immunoprecipitation (IP)
microarray
western blot
immunoprecipitation (IP)
microarray
western blot
Species reactivity:
mouse, canine, rat, human, bovine
Citations:
18
Technique(s):
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 0.1-0.2 μg/mL using HeLa nuclear extract
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 0.1-0.2 μg/mL using HeLa nuclear extract
Uniprot accession no.:
产品名称
Anti-Transportin 1 antibody, Mouse monoclonal, clone D45, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
D45, monoclonal
form
buffered aqueous solution
mol wt
antigen ~90 kDa
species reactivity
mouse, canine, rat, human, bovine
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 0.1-0.2 μg/mL using HeLa nuclear extract
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TNPO1(3842)
mouse ... Tnpo1(238799)
rat ... Tnpo1(309126)
Application
Monoclonal Anti-Transportin 1 antibody produced in mouse has been used in western blotting, immunofluorescence, and immunostaining.
Biochem/physiol Actions
Transportin 1 (TNPO1 or TRN1) recognizes the nuclear localization signals (NLS) and binds to the nuclear pore complex (NPC) to facilitate the transport of substances from cytoplasm to nucleus. TRN1 transports viral, and ribosomal proteins with the aid of RanGTP (Ras associated nuclear protein-GTP). TRN1 is also known to regulate the key events in the cell cycle assembly like nuclear membrane and nuclear pore. Mutations in TRN1 might cause amyotrophic lateral sclerosis due to mislocalisation of FUS (fused in sarcoma) protein. TRN1 is associated with regulation of circadian rhythm through nuclear localization of PER1 (period circadian protein homolog 1) protein.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Transportin 1 (TNPO1 or TRN1) also known as karyopherin-β2, is a nuclear import protein and belongs to importin-β family. In the human chromosome the TNPO1 gene is localized on 5q13.2.(10)
Transportin 1 encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes
Immunogen
recombinant human transportin 1.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Structural basis for substrate recognition and dissociation by human transportin 1
Imasaki T, et al.
Molecular Cell, 28(1), 57-67 (2007)
IPO3 mediated nonclassical nuclear import of NEMO drives DNA damage-dependent NF-kappaB activation
Hwang B, et al.
The Journal of Biological Chemistry, jbc-M115 (2015)
Imke Baade et al.
The Journal of biological chemistry, 296, 100659-100659 (2021-04-16)
Fused in sarcoma (FUS) is a predominantly nuclear RNA-binding protein with key functions in RNA processing and DNA damage repair. Defects in nuclear import of FUS have been linked to severe neurodegenerative diseases; hence, it is of great interest to
Transcriptional regulation of importin-alpha1 by JunD modulates subcellular localization of RNA-binding protein HuR in intestinal epithelial cells
Xu Y, et al.
American Journal of Physiology. Cell Physiology, 311(6), C874-C883 (2016)
microRNA miR-128 represses LINE-1 retrotransposition by downregulating the nuclear import factor TNPO1
Idica A, et al.
The Journal of Biological Chemistry, 28(1), jbc-M117 (2017)
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