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T1505

四异丙基焦磷酸亚胺

Name: 四异丙基焦磷酸亚胺
Brand: SIGMA

butyrylcholinesterase inhibitor

别名:

四（单阳离子基）焦磷酸四胺, 异-OMPA

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关于此项目

经验公式（希尔记法）:

C₁₂H₃₂N₄O₃P₂

化学文摘社编号:

513-00-8

分子量:

342.36

NACRES:

NA.77

PubChem Substance ID:

24278724

UNSPSC Code:

12352202

EC Number:

208-149-5

MDL number:

MFCD00048272

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biological source

synthetic

mp

149-151 °C

storage temp.

−20°C

SMILES string

CC(C)NP(=O)(NC(C)C)OP(=O)(NC(C)C)NC(C)C

InChI

1S/C12H32N4O3P2/c1-9(2)13-20(17,14-10(3)4)19-21(18,15-11(5)6)16-12(7)8/h9-12H,1-8H3,(H2,13,14,17)(H2,15,16,18)

InChI key

IOIMDJXKIMCMIG-UHFFFAOYSA-N

Gene Information

human ... ACHE(43), BCHE(590)

Application

四异丙基焦磷酰胺已被用于：

作为丁酰胆碱酯酶抑制剂，用于测定猫和虎血浆中丁酰胆碱酯酶 (BChE) 的比例
在乙酰胆碱酯酶测定中抑制野生型 BChE
选择性阻断 AChE 的酶活性

Biochem/physiol Actions

丁酰胆碱酯酶的选择性抑制剂

Disclaimer

警告：极其危险！在使用本产品之前，请注意风险并熟悉安全程序。

pictograms

GHS06

signalword

Danger

hcodes

H300 + H310 + H330

pcodes

P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

存储类别

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase

Wang YW, et al.

Toxicology and Applied Pharmacology, 196(3), 356-366 (2004)

Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma.

Bartels CF, et al.

Biochemical Pharmacology, 60(4), 479-487 (2018)

Postnatal development of nitrergic and cholinergic structures in rat spinal cord

Bolekova A, et al.

Archives Italiennes de Biologie, 149(3), 293-302 (2011)

Gene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicity.

Liyi Geng et al.

PloS one, 8(6), e67446-e67446 (2013-07-11)

Gene transfer of a human cocaine hydrolase (hCocH) derived from butyrylcholinesterase (BChE) by 5 mutations (A199S/F227A/S287G/A328W/Y332G) has shown promise in animal studies for treatment of cocaine addiction. To predict the physiological fate and immunogenicity of this enzyme in humans, a

Tissue distribution and characterization of cholinesterase activity in six earthworm species.

Magali Rault et al.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 147(2), 340-346 (2007-03-10)

To validate cholinesterase activity as a biomarker of pesticide exposure, we characterized the tissue distribution (whole body, nervous tissue and crop/gizzard), activity at two seasons of cholinesterase in six different species of earthworms collected in an unpolluted field: Lumbricus terrestris

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全球贸易项目编号

货号	GTIN
T1505-1G	04061826745823
T1505-250MG	04061837337642
T1505-100MG	04061837337635

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