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Merck
CN

T1505

Sigma-Aldrich

四异丙基焦磷酸亚胺

butyrylcholinesterase inhibitor

别名:

四(单阳离子基)焦磷酸四胺, 异-OMPA

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关于此项目

经验公式(希尔记法):
C12H32N4O3P2
化学文摘社编号:
分子量:
342.36
EC 号:
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
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生物来源

synthetic

mp

149-151 °C

储存温度

−20°C

SMILES字符串

CC(C)NP(=O)(NC(C)C)OP(=O)(NC(C)C)NC(C)C

InChI

1S/C12H32N4O3P2/c1-9(2)13-20(17,14-10(3)4)19-21(18,15-11(5)6)16-12(7)8/h9-12H,1-8H3,(H2,13,14,17)(H2,15,16,18)

InChI key

IOIMDJXKIMCMIG-UHFFFAOYSA-N

基因信息

human ... ACHE(43), BCHE(590)

应用

四异丙基焦磷酰胺已被用于:
  • 作为丁酰胆碱酯酶抑制剂,用于测定猫和虎血浆中丁酰胆碱酯酶 (BChE) 的比例
  • 在乙酰胆碱酯酶测定中抑制野生型 BChE
  • 选择性阻断 AChE 的酶活性

生化/生理作用

丁酰胆碱酯酶的选择性抑制剂

免责声明

警告:极其危险!在使用本产品之前,请注意风险并熟悉安全程序。

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

储存分类代码

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Postnatal development of nitrergic and cholinergic structures in rat spinal cord
Bolekova A, et al.
Archives Italiennes de Biologie, 149(3), 293-302 (2011)
A A Kousba et al.
Toxicology, 188(2-3), 219-232 (2003-05-28)
The primary mechanism of action for organophosphorus (OP) insecticides such as chlorpyrifos (CPF) involves the inhibition of acetylcholinesterase (AChE) by their active oxon metabolites resulting in a wide range of neurotoxic effects. These oxons also inhibit other cholinesterases (ChE) such
Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase
Wang YW, et al.
Toxicology and Applied Pharmacology, 196(3), 356-366 (2004)
Souren Mkrtchian et al.
Experimental physiology, 105(9), 1634-1647 (2020-07-12)
What is the central question of this study? Are carotid bodies (CBs) modulated by the damage-associated molecular patterns (DAMPs) and humoral factors of aseptic tissue injury? What are the main findings and their importance? DAMPs (HMGB1, S100 A8/A9) and blood
M Isabel Arufe et al.
Aquatic toxicology (Amsterdam, Netherlands), 84(3), 328-336 (2007-08-11)
Assessment of cholinesterase (ChE) inhibition is widely used as a specific biomarker for evaluating the exposure and effects of non-target organisms to anticholinesterase agents. Cholinesterase and carboxylesterase activities have been measured in larvae of gilthead seabream, Sparus aurata, during the

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