T1505
四异丙基焦磷酸亚胺
butyrylcholinesterase inhibitor
别名:
四（单阳离子基）焦磷酸四胺, 异-OMPA
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关于此项目
经验公式（希尔记法）:
C12H32N4O3P2
化学文摘社编号:
分子量:
342.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
208-149-5
MDL number:
InChI key
IOIMDJXKIMCMIG-UHFFFAOYSA-N
InChI
1S/C12H32N4O3P2/c1-9(2)13-20(17,14-10(3)4)19-21(18,15-11(5)6)16-12(7)8/h9-12H,1-8H3,(H2,13,14,17)(H2,15,16,18)
SMILES string
CC(C)NP(=O)(NC(C)C)OP(=O)(NC(C)C)NC(C)C
biological source
synthetic
mp
149-151 °C
storage temp.
−20°C
Application
四异丙基焦磷酰胺已被用于：
- 作为丁酰胆碱酯酶抑制剂，用于测定猫和虎血浆中丁酰胆碱酯酶 (BChE) 的比例
- 在乙酰胆碱酯酶测定中抑制野生型 BChE
- 选择性阻断 AChE 的酶活性
Biochem/physiol Actions
丁酰胆碱酯酶的选择性抑制剂
Disclaimer
警告：极其危险！在使用本产品之前，请注意风险并熟悉安全程序。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral
存储类别
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Postnatal development of nitrergic and cholinergic structures in rat spinal cord
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Gene transfer of a human cocaine hydrolase (hCocH) derived from butyrylcholinesterase (BChE) by 5 mutations (A199S/F227A/S287G/A328W/Y332G) has shown promise in animal studies for treatment of cocaine addiction. To predict the physiological fate and immunogenicity of this enzyme in humans, a
Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma.
Bartels CF, et al.
Biochemical Pharmacology, 60(4), 479-487 (2018)
Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase
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Toxicology and Applied Pharmacology, 196(3), 356-366 (2004)
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What is the central question of this study? Are carotid bodies (CBs) modulated by the damage-associated molecular patterns (DAMPs) and humoral factors of aseptic tissue injury? What are the main findings and their importance? DAMPs (HMGB1, S100 A8/A9) and blood
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