T1505
四异丙基焦磷酸亚胺
butyrylcholinesterase inhibitor
别名:
四（单阳离子基）焦磷酸四胺, 异-OMPA
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关于此项目
经验公式（希尔记法）:
C12H32N4O3P2
化学文摘社编号:
分子量:
342.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
208-149-5
MDL number:
biological source
synthetic
mp
149-151 °C
storage temp.
−20°C
SMILES string
CC(C)NP(=O)(NC(C)C)OP(=O)(NC(C)C)NC(C)C
InChI
1S/C12H32N4O3P2/c1-9(2)13-20(17,14-10(3)4)19-21(18,15-11(5)6)16-12(7)8/h9-12H,1-8H3,(H2,13,14,17)(H2,15,16,18)
InChI key
IOIMDJXKIMCMIG-UHFFFAOYSA-N
Application
四异丙基焦磷酰胺已被用于：
- 作为丁酰胆碱酯酶抑制剂，用于测定猫和虎血浆中丁酰胆碱酯酶 (BChE) 的比例
- 在乙酰胆碱酯酶测定中抑制野生型 BChE
- 选择性阻断 AChE 的酶活性
Biochem/physiol Actions
丁酰胆碱酯酶的选择性抑制剂
Disclaimer
警告：极其危险！在使用本产品之前，请注意风险并熟悉安全程序。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral
存储类别
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Postnatal development of nitrergic and cholinergic structures in rat spinal cord
Bolekova A, et al.
Archives Italiennes de Biologie, 149(3), 293-302 (2011)
Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma.
Bartels CF, et al.
Biochemical Pharmacology, 60(4), 479-487 (2018)
Liyi Geng et al.
PloS one, 8(6), e67446-e67446 (2013-07-11)
Gene transfer of a human cocaine hydrolase (hCocH) derived from butyrylcholinesterase (BChE) by 5 mutations (A199S/F227A/S287G/A328W/Y332G) has shown promise in animal studies for treatment of cocaine addiction. To predict the physiological fate and immunogenicity of this enzyme in humans, a
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T1505-1G | 04061826745823 |
| T1505-250MG | 04061837337642 |
| T1505-100MG | 04061837337635 |