质量水平
方案
≥97% (NMR)
颜色
white
溶解性
DMSO: soluble ≥22 mg/mL
SMILES字符串
CCCCCCCCCCCCCCSCC(O)=O
InChI
1S/C16H32O2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-19-15-16(17)18/h2-15H2,1H3,(H,17,18)
InChI key
IPBCWPPBAWQYOO-UHFFFAOYSA-N
基因信息
human ... PPARA(5465)
生化/生理作用
PPARα agonist; activation in ranking order: PPARδ > PPARα > PPARγ
Tetradecylthioacetic acid (TTA) is known to modulate lipid homeostasis. TTA can increase fatty acid oxidation and ketogenesis, which can subsequently prevent adiposity and insulin resistance. Furthermore, TTA can enhance cardiac functions during experimental heart failure.
特点和优势
This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
包装
在氮气保护下封装。
制备说明
Tetradecylthioacetic acid is soluble in DMSO at a concentration that is greater than or equal to 22 mg/ml.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Erik Øie et al.
Lipids, 48(2), 139-154 (2012-12-26)
Changes in myocardial metabolism, including a shift from fatty acid to glucose utilization and changes in fatty acid availability and composition are characteristics of heart failure development. Tetradecylthioacetic acid (TTA) is a fatty acid analogue lacking the ability to undergo
Lise Madsen et al.
Journal of lipid research, 43(5), 742-750 (2002-04-25)
Tetradecylthioacetic acid (TTA) is a non-beta-oxidizable fatty acid analog, which potently regulates lipid homeostasis. Here we evaluate the ability of TTA to prevent diet-induced and genetically determined adiposity and insulin resistance. In Wistar rats fed a high fat diet, TTA
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