T1952
Trichostatin A, Ready Made Solution
5 mM in DMSO, from Streptomyces sp.
别名:
TSA, [R-(E,E)]-7-[4-（二甲氨基）苯基]-N-羟基-4,6-二甲基-7-氧代-2,4-庚二烯酰胺, 曲古抑菌素 A，预制溶液
生物来源
Streptomyces sp.
质量水平
方案
≥98% (HPLC)
表单
DMSO solution
浓度
5 mM in DMSO
技术
cell culture | mammalian: suitable
抗生素抗菌谱
fungi
neoplastics
作用机制
enzyme | inhibits
运输
dry ice
储存温度
−20°C
SMILES字符串
N(O)C(=O)\C=C\C(=C\C(C)C(=O)c1ccc(cc1)N(C)C)\C
InChI
1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+
InChI key
RTKIYFITIVXBLE-WKWSCTOISA-N
一般描述
曲古抑菌素A是一种一级羟肟酸。
应用
曲古抑菌素A即用型溶液已用于：
- 作为组蛋白去乙酰化酶抑制剂，通过干细胞试验研究其对转录组变化的影响
- 抑制原代垂体细胞培养物中的I、II或III类组蛋白去乙酰化酶(HDAC)，用于研究内源性人生长激素基因(hGH)的胰岛素调节
- 处理细胞进行HDAC抑制实验
生化/生理作用
曲古抑菌素 A (Trichostatin A，TSA) 是一种 链霉菌 代谢产物，在纳摩尔浓度下特异性抑制哺乳动物组蛋白去乙酰化酶，引起哺乳动物细胞内高度乙酰化的组蛋白分子积累。因此，曲古抑菌素 A 可用作研究体内组蛋白乙酰化的工具。曲古抑菌素 A 诱导细胞分化、细胞周期阻滞、逆转转化细胞形态和凋亡，并能够调节转录。TSA 已被用于建立一种新的克隆技术，从而提高了小鼠克隆的成功率。
曲古抑菌素 A 是一种链霉菌代谢产物，特异性抑制哺乳动物组蛋白去乙酰化酶。
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Bioprobes: Biochemical Tools for Investigating Cell Function, 11, 2104-2104 (2012)
Barbara Wójcikowska et al.
Frontiers in plant science, 9, 1353-1353 (2018-10-03)
Auxin is an important regulator of plant ontogenies including embryo development and the exogenous application of this phytohormone has been found to be necessary for the induction of the embryogenic response in plant explants that have been cultured in vitro.
Negative regulation of human growth hormone gene expression by insulin is dependent on hypoxia-inducible factor binding in primary non-tumor pituitary cells
Vakili H, et al.
The Journal of Biological Chemistry, 287(40), 33282-33292 (2012)
Zn(II)-dependent histone deacetylase inhibitors: suberoylanilide hydroxamic acid and trichostatin A.
Rachel Codd et al.
The international journal of biochemistry & cell biology, 41(4), 736-739 (2008-08-30)
Suberoylanilide hydroxamic acid (SAHA, vorinostat, Zolinza) and trichostatin A (TSA) are inhibitors of the Zn(II)-dependent class I and class II histone deacetylases (HDACs), which are enzymes that operate in concert with histone acetyltransferases (HATs) to regulate the acetylation status of
M Yoshida et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 17(5), 423-430 (1995-05-01)
Reversible acetylation at the epsilon-amino group of lysines located at the conserved domain of core histones is supposed to play an important role in the regulation of chromatin structure and its transcriptional activity. One promising strategy for analyzing the precise
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