生物来源
goat
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
种属反应性
mouse
技术
indirect ELISA: suitable
western blot: suitable
UniProt登记号
储存温度
−20°C
基因信息
mouse ... Tnf(21926), Tnfrsf1a(21937), Tnfrsf1b(21938)
一般描述
Tumor Necrosis Factor Receptor II (TNF RII) is a 75kD transmembrane glycoprotein expressed mainly on endothelial cells, macrophages, Langerhans cells and monocytes. It has a crucial role in regulating TNF α function by antagonizing its biological activity that is by blocking TNF-α-induced apoptosis. Anti-Tumor Necrosis Factor Soluble Receptor II (TNF sRII) antibody can be used in western blotting. Goat anti-Tumor Necrosis Factor Soluble Receptor II antibody reacts specifically with mouse TNF sRII. This antibody has also shown less than 15% cross-reactivity for recombinant human TNF-sRII.
免疫原
recombinant mouse TNF soluble receptor II (TNF sRII) expressed in Escherichia coli.
应用
Anti-Tumor Necrosis Factor Soluble Receptor II (TNF sRII) antibody can be used in indirect ELISA.
生化/生理作用
The antibody detects mouse TNF RII and shows <15% cross-reactivity with recombinant human TNF sRII.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
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储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
J R Bradley et al.
The American journal of pathology, 146(1), 27-32 (1995-01-01)
We have used confocal immunofluorescence microscopy and immunogold electron microscopy to localize tumor necrosis factor (TNF) receptors in cultured human umbilical vein endothelial cells. The 75-kd receptor is largely expressed on the cell surface and undergoes endocytosis and transport to
E Lien et al.
European journal of immunology, 25(9), 2714-2717 (1995-09-01)
Lipopolysaccharide (LPS), a part of the Gram-negative bacteria cell wall, is a potent inducer of tumor necrosis factor (TNF). TNF is an important mediator in Gram-negative infections such as meningococcal septic shock, but its harmful action can be prevented by
B Wang et al.
Immunology, 88(2), 284-288 (1996-06-01)
Langerhans' cells (LC) represent the major antigen-presenting cells within the epidermis. Following exposure of the skin to antigen, LC take up antigen, migrate into draining lymph nodes (DLN) and present processed antigen to T lymphocytes, thereby initiating an immune response.
Begoña Lainez et al.
International immunology, 16(1), 169-177 (2003-12-23)
Tumor necrosis factor (TNF)-alpha is a pleiotropic cytokine involved in a broad spectrum of inflammatory and immune responses including proliferation, differentiation and cell death induction in several cell types. The biological effects of TNF-alpha are mediated via the cell-surface TNF
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