T3301
Transforming Growth Factor-β1 Receptor II Soluble Fragment human
≥97% (SDS-PAGE), recombinant, expressed in mouse NSO cells, lyophilized powder
别名:
TGF-β1 RII
重组
expressed in mouse NSO cells
方案
≥97% (SDS-PAGE)
表单
lyophilized powder
杂质
endotoxin, tested
储存温度
−20°C
一般描述
Transforming growth factor-β (TGF-β) belongs to the TGF-β superfamily of secreted proteins. The TGF-β family is involved in a variety of signaling pathways that involve serine/threonine protein kinases. TGF-β acts through binding to three transmembrane receptors in mammals, type I, type II and type III receptors. It is expressed by most cell types and regulates the DNA-binding activity of transcription factors. The important pathways regulated by TGF-β are the SMAD, BMP, MAPK and PI3K/Akt pathways. TGF-β is involved in cell and tissue differentiation, proliferation, morphogenesis, secretion of metalloproteases and inflammation. Deregulation of TGF-β signaling has been implicated in many developmental syndromes and cancer progression
Recombinant, human TGF-β1 soluble receptor II will bind to TGF-β1, -β2, -β3, and -β5.
Recombinant, human TGF-β1 soluble receptor II will bind to TGF-β1, -β2, -β3, and -β5.
应用
Recombinant, human TGF-β1 sRII may be used to inhibit TGF-β1 activity on mouse T cell line, HT-2.
外形
Lyophilized from 0.2 μm filtered phosphate buffered saline containing 1.25 mg bovine serum albumin
分析说明
The receptor mediated activity of human TGF-β1 receptor II soluble fragment is measured by its ability to inhibit the TGF-β1 bioactivity in HT-2 cells.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Justin P Annes et al.
Journal of cell science, 116(Pt 2), 217-224 (2002-12-17)
TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix. A variety of molecules, 'TGFbeta activators,' release TGFbeta from its latent state. The unusual temporal discontinuity of TGFbeta synthesis and action and the panoply
Pinglong Xu et al.
FEBS letters, 586(14), 1871-1884 (2012-05-24)
TGF-β family signaling through Smads is conceptually a simple and linear signaling pathway, driven by sequential phosphorylation, with type II receptors activating type I receptors, which in turn activate R-Smads. Nevertheless, TGF-β family proteins induce highly complex programs of gene
Rik Derynck et al.
Nature, 425(6958), 577-584 (2003-10-10)
Transforming growth factor-beta (TGF-beta) proteins regulate cell function, and have key roles in development and carcinogenesis. The intracellular effectors of TGF-beta signalling, the Smad proteins, are activated by receptors and translocate into the nucleus, where they regulate transcription. Although this
Joan Massagué et al.
FEBS letters, 586(14), 1953-1958 (2012-06-20)
The canonical TGF-β/Smad signaling pathway was delineated in the mid 90s and enriched over the past decade with many findings about its specificity, regulation, networking, and malfunctions in disease. However, a growing understanding of the chromatin status of a critical
Zhike Zi et al.
FEBS letters, 586(14), 1921-1928 (2012-06-20)
The physiological responses to TGF-β stimulation are diverse and vary amongst different cell types and environmental conditions. Even though the principal molecular components of the canonical and the non-canonical TGF-β signaling pathways have been largely identified, the mechanism that underlies
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