生物来源
goat
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
种属反应性
human
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL
indirect ELISA: suitable
neutralization: suitable
western blot: 0.1 μg/mL
UniProt登记号
应用
research pathology
储存温度
−20°C
基因信息
human ... TGFB3(7043)
一般描述
Transforming growth factor-β3 (TGF-β3) belongs to the TGF-β superfamily of secreted proteins. TGF-β3 has been implicated in the physiology of adult lung, brain and heart. The TGF-β family is involved in a variety of signaling pathways that involve serine/threonine protein kinases. TGF-β3 acts through binding to TGF-βR2 transmembrane receptor in mammals. The important pathways regulated by TGF-β3 are the Alk-5/SMAD, RhoA/Rho-kinase and MAPK pathways. TGF-β3 is involved in morphogenesis, development of palate, angiogenesis, induction of epithelial-mesenchymal transition Deregulation of TGF-β signaling has been implicated in many developmental syndromes and cancer progression
Anti-Transforming Growth Factor-b3 (TGF-β3) recognizes human and chicken TGF-β3. The antibody shows less than 25 % cross-reactivity with amphibian TGF-b5 and less than 10 % cross-reactivity with TGF-β1, TGF-β1.2, and TGF-β2. This antibody also shows less than 5 % cross-reactivity with recombinant human LAP (latency associated peptide, TGF-β1).
Anti-Transforming Growth Factor-b3 (TGF-β3) recognizes human and chicken TGF-β3. The antibody shows less than 25 % cross-reactivity with amphibian TGF-b5 and less than 10 % cross-reactivity with TGF-β1, TGF-β1.2, and TGF-β2. This antibody also shows less than 5 % cross-reactivity with recombinant human LAP (latency associated peptide, TGF-β1).
免疫原
Recombinant chicken transforming growth factor-β3 (TGF-β3) expressed in Sf 21 cells.
应用
Anti- Transforming growth factor-β3 (TGF-β3) antibody may be used for immunoblotting at a working concentration of 0.1 μg/ml. For immunohistochemistry a working concentration of 5-15 μg/ml may be used. The antibody is suitable for neutralization reactions (ND50 is 0.01-0.05 μg/ml).
外形
Lyophilized from a 0.2 μm filtered solution of PBS with 5% trehalose.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Marek Dudas et al.
Developmental biology, 266(1), 96-108 (2004-01-20)
Cleft palate is among the most common birth defects in humans, caused by a failure in the complex multistep developmental process of palatogenesis. It has been recently shown that transforming growth factor beta3 (Tgf-beta3) is an absolute requirement for successful
Vesa Kaartinen et al.
International journal of molecular medicine, 9(6), 563-570 (2002-05-16)
TGFbeta-induced epithelio-mesenchymal transdifferentiation (EMT) has been shown to play a pivotal role in developmental processes such as palatogenesis and heart organogenesis. Interestingly, EMT has also been shown to contribute to the promotion of invasiveness during the later stages of tumorigenesis.
Wing-Yee Lui et al.
Endocrinology, 144(4), 1139-1142 (2003-03-18)
Recent studies using Sertoli cells cultured in vitro to permit tight junction (TJ) assembly have shown that TJ dynamics are regulated, at least in part, by TGF-beta3 via the p38 mitogen activated protein (MAP) kinase pathway. This in turn regulates
P John Hart et al.
Nature structural biology, 9(3), 203-208 (2002-02-19)
Transforming growth factor-beta (TGF-beta) is the prototype of a large family of structurally related cytokines that play key roles in maintaining cellular homeostasis by signaling through two classes of functionally distinct Ser/Thr kinase receptors, designated as type I and type
Carl-Henrik Heldin et al.
FEBS letters, 586(14), 1959-1970 (2012-06-20)
Transforming growth factor-β (TGFβ) suppresses tumor formation since it inhibits cell growth and promotes apoptosis. However, in advanced cancers TGFβ elicits tumor promoting effects through its ability to induce epithelial-mesenchymal transition (EMT) which enhances invasiveness and metastasis; in addition, TGFβ
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