T4952
丹参酮IIA
≥97% (HPLC)
别名:
1,6,6-三甲基-6,7,8,9-四氢菲并[1,2-b]呋喃-10,11-二酮, 丹参酮
质量水平
方案
≥97% (HPLC)
表单
powder
颜色
orange to dark red
溶解性
methanol: 5 mg/mL, clear, red-orange to red
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
2-8°C
SMILES字符串
Cc1coc2-c3ccc4c(CCCC4(C)C)c3C(=O)C(=O)c12
InChI
1S/C19H18O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,9H,4-5,8H2,1-3H3
InChI key
HYXITZLLTYIPOF-UHFFFAOYSA-N
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一般描述
丹参酮IIA (Tan IIA) 是一种天然二萜醌, 是来源于 丹参根提取物的一种亲脂性成分。
应用
丹参酮IIA 已被用于：
- 在卵巢切除术诱导的骨质疏松小鼠模型中测试其对破骨细胞分化的影响
- 测试其对小神经胶质细胞的影响并研究其对缺血再灌注损伤大鼠脑的神经保护作用
- 在体外 和体内模型中研究其对急性髓系白血病（AML）增殖、凋亡和自噬的影响
- 研究其对ATDC5细胞中脂多糖（LPS）诱导的炎症损伤的抗炎和保护作用
生化/生理作用
中药丹参（Salvia miltiorrhiza）的菲醌类成分。抗炎。抗氧化。对多种细胞系（包括人神经胶质瘤细胞）具有细胞毒性。
丹参酮IIA通过增强血管生成防止心血管疾病。它还具有神经保护、抗癌、抗糖尿病和抗肥胖特性。Tan-IIA 在调节免疫细胞的发育和功能方面起重要作用。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Rui Guo et al.
Drug design, development and therapy, 14, 4735-4748 (2020-11-17)
Salvia miltiorrhiza: (Danshen) is a significant (traditional Chinese medication) natural remedy, enhancing blood circulation and clear blood stasis. In this view, it is widely used against several heart diseases, eg, cardiomyopathy, arrhythmia, and congenital heart defects. Tanshinone IIA (tan-IIA) is
Zhibing Song et al.
Frontiers in pharmacology, 12, 641848-641848 (2021-05-07)
Tanshinone IIA, a fat-soluble diterpenoid isolated from Salvia miltiorrhiza Bunge, has been shown to attenuate the cerebral ischemic injury. The aim of this study was to examine the effects on neuroprotection and microglia activation of Tanshinone IIA. Male Sprague-Dawley rats
Mohammad Azam Ansari et al.
Pharmacological research, 164, 105364-105364 (2020-12-08)
In the past decades, the branch of complementary and alternative medicine based therapeutics has gained considerable attention worldwide. Pharmacological efficacy of various traditional medicinal plants, their products and/or product derivatives have been explored on an increasing scale. Tanshinone IIA (Tan
Zhong-Ying Fang et al.
Frontiers in pharmacology, 11, 611087-611087 (2021-02-19)
Tanshinone IIA (Tan IIA) is a pharmacologically lipophilic active constituent isolated from the roots and rhizomes of the Chinese medicinal herb Salvia miltiorrhiza Bunge (Danshen). Tan IIA is currently used in China and other neighboring countries to treat patients with
Weiyang Tang et al.
Journal of separation science, 41(17), 3372-3381 (2018-07-15)
A hydrophobic ionic liquid modified thermoresponsive molecularly imprinted monolith was synthesized using N-isopropylacrylamide as a thermoresponsive monomer and a long-chain hydrophobic ionic liquid as an auxiliary modification monomer. The ionic-liquid-modified thermoresponsive molecularly imprinted polymer was characterized by scanning electron microscopy
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