生物来源
human
质量水平
重组
expressed in NSO cells
描述
N-terminal 6X histidine-tagged extracellular domain
方案
>97% (SDS-PAGE)
表单
lyophilized powder
分子量
24 kDa by SDS-PAGE
predicted mol wt ~21 kDa
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
基因信息
human ... TNFSF10(8743)
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应用
TRAIL human was used to induce cytotoxicity in A549, a human lung carcinoma cell line.
生化/生理作用
TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that belongs to TNF family. It is present in both soluble as well as membrane-bound form and can induce rapid apoptosis of various transformed cell lines but not the normal cells. Additionally, the product can also induces apoptotic cell death in TRAIL-sensitive U343MGcells.
Type II transmembrane protein of the TNF superfamily. Ligand for apoptosis-inducing death receptors DR4 and DR5, decoy receptors DcR1 and DcR2, and osteoprotegerin. Approximately 28% amino acid sequence identity to FAS ligand. Human and mouse TRAIL share 65% sequence identity.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.
分析说明
Induces cytotoxicity in mouse L-929 cells in the presence of actinomycin D.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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