T6575
TOFA
≥98% (HPLC)
别名:
5-（十四烷氧基）-2-糠酸
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关于此项目
经验公式（希尔记法）:
C19H32O4
化学文摘社编号:
分子量:
324.45
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
TOFA, ≥98% (HPLC)
InChI key
CZRCFAOMWRAFIC-UHFFFAOYSA-N
SMILES string
CCCCCCCCCCCCCCOc1ccc(o1)C(O)=O
InChI
1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21)
assay
≥98% (HPLC)
form
powder
color
white to beige
mp
112-115 °C
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Quality Level
相关类别
Application
TOFA已被用作 ACC抑制剂，以研究其对 INS-1E细胞中胰岛素分泌的影响。
TOFA用作可用作：间充质基质细胞(MSC)、人类多功能干细胞中的脂类生化合成抑制剂。小鼠脂肪细胞系中的乙酰-辅酶A羧化酶1抑制剂。一种癌症干细胞(CSC)的脂解抑制剂。
Biochem/physiol Actions
5-(十四环氧基)-2-呋喃甲酸(TOFA)可促进脂肪酸分解并阻止生物合成，实现降血脂功能。它能诱导胰腺癌细胞凋亡，促进肿瘤抑制。
TOFA是乙酰辅酶A 羧化酶（ACC）的细胞渗透性、有效、可逆和竞争性抑制剂。
TOFA是乙酰辅酶A 羧化酶（ACC）的细胞渗透性、有效、可逆和竞争性抑制剂。 TOFA是参与脂肪酸生物合成的关键酶。TOFA以剂量依赖性方式抑制细胞脂肪酸合成（人乳腺癌细胞系 MCF7中IC50 = 4 μM）。
研究报道，在大鼠再喂食实验期间，TOFA可以抑制皮下他莫昔芬（TMX）对食物摄入的厌食作用。
Preparation Note
TOFA以大于2mg/ml的浓度溶于DMSO。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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