T7450
T62
≥98% (HPLC), crystalline
别名:
2-Amino-3-(4-chlorobenzoyl)-5,6,7,8-tetrahydrobenzothiophene
质量水平
方案
≥98% (HPLC)
表单
crystalline
颜色
orange
溶解性
DMSO: ~20 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
Nc1sc2CCCCc2c1C(=O)c3ccc(Cl)cc3
InChI
1S/C15H14ClNOS/c16-10-7-5-9(6-8-10)14(18)13-11-3-1-2-4-12(11)19-15(13)17/h5-8H,1-4,17H2
InChI key
OTZVBZFYMFTYKH-UHFFFAOYSA-N
基因信息
human ... ADORA1(134)
生化/生理作用
Allosteric enhancer of A1 adenosine receptor.
Studies in carrageenin-inflamed rats have reported that T62 can reverse thermal hypersensitivity. T62 has also been reported to reduce mechanical allodynia and induce drug tolerance over time in rat models of neuropathic pain.
制备说明
T62 is soluble in DMSO at approximately 20 mg/ml and is insoluble in water.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Xinhui Li et al.
The Journal of pharmacology and experimental therapeutics, 305(3), 950-955 (2003-02-28)
Activation of adenosine A1 receptors by endogenous adenosine or synthetic agonists produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain. Allosteric adenosine modulators facilitate and potentiate the action of adenosine
Hideaki Obata et al.
Anesthesiology, 100(5), 1258-1262 (2004-04-29)
Intrathecal adenosine has antinociceptive effects under conditions of hypersensitivity. T62 (2-amino-3-(4-chlorobenzoyl)-5,6,7,8-tetrahydrobenzothiophen) is an allosteric adenosine receptor modulator that enhances adenosine binding to the A1 receptor. Intrathecal T62 reduces hypersensitivity to mechanical stimuli in a rat model of neuropathic pain by
Xinhui Li et al.
Anesthesiology, 100(4), 956-961 (2004-04-17)
The positive allosteric adenosine receptor modulator, T62 (2-amino-3-(4-chlorobenzoyl)-5,6,7,8-tetrahydrobenzothiophene), has been shown to reduce mechanical allodynia in a rat model of neuropathic pain. However, whether chronic oral T62 retains efficacy in this pain model has not been examined. Therefore, the authors
Willem Soudijn et al.
Drug discovery today, 9(17), 752-758 (2004-09-29)
Allosteric modulation of G protein-coupled receptors has recently been recognized as an alternative approach to gain selectivity in drug action. In this overview, allosteric modulators that enhance or diminish the effects of (endogenous) agonists or antagonists on a variety of
Sarah R Bilskey et al.
SLAS technology, 25(5), 494-504 (2020-03-01)
The quantitation of sugars, including glucose, the primary fermentable sugar; maltose (DP2); and maltotriose (DP3), is a standard procedure during the corn-to-ethanol fermentation process. The quantitation of glucose by the Megazyme Assay utilizing glucose oxidase and peroxidase enzymes (GOPOD) and
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