T9567
Thiolactomycin
98% (HPLC), solid
别名:
(5R)-4-Hydroxy-3,5-dimethyl-5-[(1E)-2-methyl-1,3-butadienyl]-2(5H)-thiophenone, Antibiotic 2-200, [R-(E)]-4-Hydroxy-3,5-dimethyl-5-(2-methyl-1,3-butadienyl)-2(5H)-thiophenone
方案
98% (HPLC)
表单
solid
颜色
light yellow
溶解性
DMSO: soluble ~21 mg/mL
H2O: insoluble
SMILES字符串
C\C(C=C)=C/[C@@]1(C)SC(=O)C(C)=C1O
基因信息
human ... FASN(2194)
生化/生理作用
Inhibitor of bacterial myristate synthesis. Does not inhibit eukaryotic myristate synthesis; antibiotic; antitrypanosomal. Shown to be effective against human sleeping sickness parasite, Trypanosoma brucei, as well as malaria parasite and toxoplasma.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Variable synthesis of the optically active thiotetronic acid antibiotics thiolactomycin, thiotetromycin, and 834-B1.
Korinna L Dormann et al.
Angewandte Chemie (International ed. in English), 46(7), 1160-1163 (2006-12-22)
Pilho Kim et al.
Journal of medicinal chemistry, 49(1), 159-171 (2006-01-06)
Thiolactomycin inhibits bacterial cell growth through inhibition of the beta-ketoacyl-ACP synthase activity of type II fatty acid synthases. The effect of modifications of the 5-position isoprenoid side chain on both IC(50) and MIC were determined. Synthesis and screening of a
Sylvia R Luckner et al.
Structure (London, England : 1993), 17(7), 1004-1013 (2009-07-17)
Mycobacteria have a unique cell wall consisting of mycolic acids, very-long-chain lipids that provide protection and allow the bacteria to persist within human macrophages. Inhibition of cell wall biosynthesis is fatal for the organism and a starting point for the
Thomas Steinbrecher et al.
Bioorganic & medicinal chemistry, 20(11), 3446-3453 (2012-05-09)
Finding novel antibiotics to combat the rise of drug resistance in harmful bacteria is of enormous importance for human health. Computational drug design can be employed to aid synthetic chemists in the search for new potent inhibitors. In recent years
Jill M McFadden et al.
Journal of medicinal chemistry, 48(4), 946-961 (2005-02-18)
Fatty acid synthase (FAS) catalyzes the synthesis of palmitate from the sequential condensation of an acetyl primer with two carbon units added from malonyl-CoA. Inhibition of the beta-ketoacyl synthase domain of mammalian FAS leads to selective cytotoxicity to various cancer
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持