T9567
Thiolactomycin
98% (HPLC), solid
别名:
(5R)-4-Hydroxy-3,5-dimethyl-5-[(1E)-2-methyl-1,3-butadienyl]-2(5H)-thiophenone, Antibiotic 2-200, [R-(E)]-4-Hydroxy-3,5-dimethyl-5-(2-methyl-1,3-butadienyl)-2(5H)-thiophenone
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关于此项目
经验公式（希尔记法）:
C11H14O2S
化学文摘社编号:
分子量:
210.29
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
C\C(C=C)=C/[C@@]1(C)SC(=O)C(C)=C1O
assay
98% (HPLC)
form
solid
color
light yellow
solubility
DMSO: soluble ~21 mg/mL, H2O: insoluble
Gene Information
human ... FASN(2194)
Biochem/physiol Actions
Inhibitor of bacterial myristate synthesis. Does not inhibit eukaryotic myristate synthesis; antibiotic; antitrypanosomal. Shown to be effective against human sleeping sickness parasite, Trypanosoma brucei, as well as malaria parasite and toxoplasma.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Simon M Jones et al.
Bioorganic & medicinal chemistry, 12(4), 683-692 (2004-02-05)
A series of analogues of the naturally occurring antibiotic thiolactomycin (TLM) have been synthesised and evaluated for their ability to inhibit the growth of the malaria parasite, Plasmodium falciparum. Thiolactomycin is an inhibitor of Type II fatty acid synthase which
Thomas Steinbrecher et al.
Bioorganic & medicinal chemistry, 20(11), 3446-3453 (2012-05-09)
Finding novel antibiotics to combat the rise of drug resistance in harmful bacteria is of enormous importance for human health. Computational drug design can be employed to aid synthetic chemists in the search for new potent inhibitors. In recent years
Zbigniew J Witczak et al.
Applied microbiology and biotechnology, 69(3), 237-244 (2005-10-22)
Thiosugars, containing a sulfur atom as heteroatom or a disaccharide linked via a sulfur bridge, possess unique physicochemical properties such as water solubility, which differs from conventional functionalized monosaccharides. The differences in biological activities between thiosugars and their oxygen analogs
Sylvia R Luckner et al.
Structure (London, England : 1993), 17(7), 1004-1013 (2009-07-17)
Mycobacteria have a unique cell wall consisting of mycolic acids, very-long-chain lipids that provide protection and allow the bacteria to persist within human macrophages. Inhibition of cell wall biosynthesis is fatal for the organism and a starting point for the
Carl A Machutta et al.
The Journal of biological chemistry, 285(9), 6161-6169 (2009-12-19)
Thiolactomycin (TLM), a natural product thiolactone antibiotic produced by species of Nocardia and Streptomyces, is an inhibitor of the beta-ketoacyl-acyl carrier protein synthase (KAS) enzymes in the bacterial fatty acid synthase pathway. Using enzyme kinetics and direct binding studies, TLM
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