T9778
托吡卡胺
Muscarinic receptor antagonist, solid
别名:
N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide, Ro 1-7683
产品名称
托吡卡胺, solid
表单
solid
质量水平
颜色
white
溶解性
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.3 mg/mL
ethanol: 5.6 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
CCN(Cc1ccncc1)C(=O)C(CO)c2ccccc2
InChI
1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3
InChI key
BGDKAVGWHJFAGW-UHFFFAOYSA-N
基因信息
human ... CHRM3(1131), CHRM4(1132)
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相关类别
应用
Tropicamide has been used for studying the regulation of fragile X behavior in male mice. 1% tropicamide has also been used for dilating mice pupils.
生化/生理作用
M4 muscarinic acetylcholine receptor antagonist.
特点和优势
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
制备说明
Tropicamide is soluble in 45% (w/v) aqueous 2-hydroxypropyl-beta-cyclodextrin (4.3 mg/mL) and ethanol (5.6 mg/mL).
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Raghavan Lavanya et al.
Ophthalmology, 119(3), 474-480 (2011-11-29)
To evaluate the risk of primary acute angle closure (AAC), changes in intraocular pressure (IOP), and associated risk factors after pupil dilation in Asian subjects with narrow angles (primary angle-closure suspects [PACS]). Prospective clinical study. A total of 471 subjects
Surabi Veeraragavan et al.
Behavioral neuroscience, 125(5), 783-790 (2011-09-29)
Muscarinic acetylcholine receptors (mAChR) are G protein-coupled receptors (M1-M5), grouped together into two functional classes, based on their G protein interaction. Although ubiquitously expressed in the CNS, the M4 protein shows highest expression in the neostriatum, cortex, and hippocampus. Electrophysiological
Shanu Markand et al.
Investigative ophthalmology & visual science, 56(4), 2684-2695 (2015-03-15)
Methylenetetrahydrofolate reductase (Mthfr) is a key enzyme in homocysteine-methionine metabolism. We investigated Mthfr expression in retina and asked whether mild hyperhomocysteinemia, due to Mthfr deficiency, alters retinal neurovascular structure and function. Expression of Mthfr was investigated at the gene and
Tin A Tun et al.
Investigative ophthalmology & visual science, 56(5), 3337-3344 (2015-05-30)
To characterize an optical coherence tomography (OCT)-derived parameter, Bruch's membrane opening-minimum rim width (BMO-MRW), and its association with demographic and clinical parameters in normal Chinese subjects. Right eyes of 466 consecutive healthy subjects from a population-based study of Singaporean Chinese
Kyoungmin Park et al.
The American journal of pathology, 178(2), 688-698 (2011-02-02)
Pigment epithelium-derived factor (PEDF) is a serine proteinase inhibitor with antiangiogenic activities. To investigate whether PEDF overexpression has an impact on ocular neovascularization in vivo, we generated PEDF transgenic (PEDF-Tg) mice that ubiquitously express human PEDF driven by the β-actin
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