U109
R(+)-UH-301 hydrochloride
solid
别名:
R(+)-5-Fluoro-8-Hydroxy-DPAT hydrochloride, R(+)-5-Fluoro-8-hydroxy-2-dipropylamino-1,2,3,4-tetrahydronaphthalene hydrochloride
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关于此项目
经验公式（希尔记法）:
C16H24FNO · HCl
化学文摘社编号:
分子量:
301.83
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Form:
solid
form
solid
optical activity
[α]25/D +81.4°, c = 0.30 in methanol(lit.)
color
white
solubility
H2O: slightly soluble, ethanol: soluble
SMILES string
Cl[H].CCCN(CCC)[C@@H]1CCc2c(F)ccc(O)c2C1
InChI
1S/C16H24FNO.ClH/c1-3-9-18(10-4-2)12-5-6-13-14(11-12)16(19)8-7-15(13)17;/h7-8,12,19H,3-6,9-11H2,1-2H3;1H/t12-;/m1./s1
InChI key
FKUVCCNCUAFKAH-UTONKHPSSA-N
Gene Information
human ... HTR1A(3350)
Biochem/physiol Actions
R(+)-UH-301 hydrochloride is a potent and selective 5-HT1A serotonin receptor agonist. R(+)-UH-301 is also known to function as an antinociceptive agent, as it has been shown to significantly decrease formalin-induced flinching in rats.
Preparation Note
R(+)-UH-301 hydrochloride is soluble in ethanol and is slightly soluble in water.
Disclaimer
Hygroscopic, photosensitive
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Y Minabe et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2(2), 127-133 (1992-06-11)
In this study, we examined the effects of acute and chronic administration of the 5-HT3 receptor antagonist granisetron (0.1, 1.0 or 10 mg/kg i.p.) alone or in combination with haloperidol (0.5 mg/kg i.p.) on the number of spontaneously active dopamine
V Granados-Soto et al.
Neuroscience, 165(2), 561-568 (2009-10-20)
This study assessed the possible antinociceptive role of peripheral 5-HT(1) receptor subtypes in the rat formalin test. Rats were injected into the dorsum of the hind paw with 50 microl of diluted formalin (1%). Nociceptive behavior was quantified as the
L Björk et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2(2), 141-147 (1992-06-01)
The effects of the enantiomers of 5-fluoro-8-hydroxy-2-(dipropylamino)tetralin, UH-301 and the potent 5-HT1A-receptor agonist (R)-8-hydroxy-2-(dipropylamino)tetralin, (R)-8-OH-DPAT, on locomotion, rearing and total activity were studied in rats. The experiments were performed as tests either of exploratory activity in non-habituated rats or of
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| U109-1MG | 04061825983820 |
| U109-5MG | 04061832277103 |