U109
R(+)-UH-301 hydrochloride
solid
别名:
R(+)-5-Fluoro-8-Hydroxy-DPAT hydrochloride, R(+)-5-Fluoro-8-hydroxy-2-dipropylamino-1,2,3,4-tetrahydronaphthalene hydrochloride
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关于此项目
经验公式（希尔记法）:
C16H24FNO · HCl
化学文摘社编号:
分子量:
301.83
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI
1S/C16H24FNO.ClH/c1-3-9-18(10-4-2)12-5-6-13-14(11-12)16(19)8-7-15(13)17;/h7-8,12,19H,3-6,9-11H2,1-2H3;1H/t12-;/m1./s1
SMILES string
Cl[H].CCCN(CCC)[C@@H]1CCc2c(F)ccc(O)c2C1
InChI key
FKUVCCNCUAFKAH-UTONKHPSSA-N
form
solid
optical activity
[α]25/D +81.4°, c = 0.30 in methanol(lit.)
color
white
solubility
H2O: slightly soluble, ethanol: soluble
Gene Information
human ... HTR1A(3350)
Biochem/physiol Actions
R(+)-UH-301 hydrochloride is a potent and selective 5-HT1A serotonin receptor agonist. R(+)-UH-301 is also known to function as an antinociceptive agent, as it has been shown to significantly decrease formalin-induced flinching in rats.
Preparation Note
R(+)-UH-301 hydrochloride is soluble in ethanol and is slightly soluble in water.
Disclaimer
Hygroscopic, photosensitive
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Y Minabe et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2(2), 127-133 (1992-06-11)
In this study, we examined the effects of acute and chronic administration of the 5-HT3 receptor antagonist granisetron (0.1, 1.0 or 10 mg/kg i.p.) alone or in combination with haloperidol (0.5 mg/kg i.p.) on the number of spontaneously active dopamine
V Granados-Soto et al.
Neuroscience, 165(2), 561-568 (2009-10-20)
This study assessed the possible antinociceptive role of peripheral 5-HT(1) receptor subtypes in the rat formalin test. Rats were injected into the dorsum of the hind paw with 50 microl of diluted formalin (1%). Nociceptive behavior was quantified as the
L Björk et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2(2), 141-147 (1992-06-01)
The effects of the enantiomers of 5-fluoro-8-hydroxy-2-(dipropylamino)tetralin, UH-301 and the potent 5-HT1A-receptor agonist (R)-8-hydroxy-2-(dipropylamino)tetralin, (R)-8-OH-DPAT, on locomotion, rearing and total activity were studied in rats. The experiments were performed as tests either of exploratory activity in non-habituated rats or of
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
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