U2383
Ubiquitin Carrier Protein H3/CDC34 human
≥95% (SDS-PAGE), recombinant, expressed in E. coli overproducing strain
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100 G
CN¥413.41
500 G
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25 KG
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About This Item
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此商品 | V900003 | B11400 | 579408 |
|---|---|---|---|
| assay ≥99.0% (HPLC) | assay 98% | assay 99% | assay 95% |
| Quality Level 200 | Quality Level - | Quality Level 200 | Quality Level - |
| density 1.36 g/cm3 at 20 °C | density - | density - | density - |
| mp 99 °C | mp 97-99 °C (lit.) | mp 97-99 °C (lit.) | mp 108-112 °C (lit.) |
| bp 350 °C/1013 hPa | bp - | bp - | bp - |
| storage temp. 2-30°C | storage temp. - | storage temp. - | storage temp. - |
生化/生理作用
Cdc34 is an essential gene for viability in yeast. Cdc34 mediates the transition from G1 to S-phase of the cell cycle by degrading the S-phase cyclin/CDK inhibitor, SIC1 in yeast and p27(KIP1) in human. Cdc34 is also known to interact with the Skp1/Cdc53/F-box (SCF) ubiquitin ligase subunits Cul1 to degrade the NF-κB inhibitor IκBα in a phosphorylation-dependent manner.
Infected cell protein 0 of herpes simplex virus 1 was shown to bind UbcH3 and induce its degradation by promoting its polyubiquination. This resulted in increased expression of an UbcH3-target gene cyclin D1 and aided in further viral infection. [1]
外形
Solution in 50 mM HEPES, 200 mM NaCl, 1 mM TCEP (pH 7.5), and 10% glycerol.
其他说明
Manufactured for Sigma by Boston Biochem. Inc.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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