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U2383

Ubiquitin Carrier Protein H3/CDC34 human

Name: Ubiquitin Carrier Protein H3/CDC34 human
Brand: SIGMA

≥95% (SDS-PAGE), recombinant, expressed in E. coli overproducing strain

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关于此项目

UNSPSC Code:

12352202

NACRES:

NA.56

MDL number:

MFCD03101856

Form:

solution

Assay:

≥95% (SDS-PAGE)

Biological source:

human

Recombinant:

expressed in E. coli overproducing strain

Mol wt:

~32 kDa

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属性

biological source

human

Quality Segment

200

recombinant

expressed in E. coli overproducing strain

assay

≥95% (SDS-PAGE)

form

solution

mol wt

~32 kDa

UniProt accession no.

P49427, P61088

application(s)

cell analysis

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CDC34(997), UBE2N(7334)

说明

Biochem/physiol Actions

Cdc34 is an essential gene for viability in yeast. Cdc34 mediates the transition from G₁ to S-phase of the cell cycle by degrading the S-phase cyclin/CDK inhibitor, SIC1 in yeast and p27(KIP1) in human. Cdc34 is also known to interact with the Skp1/Cdc53/F-box (SCF) ubiquitin ligase subunits Cul1 to degrade the NF-κB inhibitor IκBα in a phosphorylation-dependent manner.

Infected cell protein 0 of herpes simplex virus 1 was shown to bind UbcH3 and induce its degradation by promoting its polyubiquination. This resulted in increased expression of an UbcH3-target gene cyclin D1 and aided in further viral infection.

Physical form

Solution in 50 mM HEPES, 200 mM NaCl, 1 mM TCEP (pH 7.5), and 10% glycerol.

Other Notes

Manufactured for Sigma by Boston Biochem. Inc.

存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Lot/Batch Number

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全球贸易项目编号

货号	GTIN
U2383-100UG	04061838166432