U2383
Ubiquitin Carrier Protein H3/CDC34 human
≥95% (SDS-PAGE), recombinant, expressed in E. coli overproducing strain
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此商品 | V900003 | B11400 | 579408 |
|---|---|---|---|
| assay ≥99.0% (HPLC) | assay 98% | assay 99% | assay 95% |
| Quality Level 200 | Quality Level - | Quality Level 200 | Quality Level - |
| form solid | form - | form powder | form - |
| bp 350 °C/1013 hPa | bp - | bp - | bp - |
| storage temp. 2-30°C | storage temp. - | storage temp. - | storage temp. - |
| density 1.36 g/cm3 at 20 °C | density - | density - | density - |
生化/生理作用
Cdc34 is an essential gene for viability in yeast. Cdc34 mediates the transition from G1 to S-phase of the cell cycle by degrading the S-phase cyclin/CDK inhibitor, SIC1 in yeast and p27(KIP1) in human. Cdc34 is also known to interact with the Skp1/Cdc53/F-box (SCF) ubiquitin ligase subunits Cul1 to degrade the NF-κB inhibitor IκBα in a phosphorylation-dependent manner.
Infected cell protein 0 of herpes simplex virus 1 was shown to bind UbcH3 and induce its degradation by promoting its polyubiquination. This resulted in increased expression of an UbcH3-target gene cyclin D1 and aided in further viral infection. [1]
外形
Solution in 50 mM HEPES, 200 mM NaCl, 1 mM TCEP (pH 7.5), and 10% glycerol.
其他说明
Manufactured for Sigma by Boston Biochem. Inc.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
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Ryan Hagglund et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(2), 631-636 (2002-01-24)
Infected cell protein 0 (ICP0) of herpes simplex virus 1, a multifunctional ring finger protein, enhances the expression of genes introduced into cells by infection or transfection, interacts with numerous cellular and viral proteins, and is associated with the degradation
Evangelia Koutelou et al.
The Journal of biological chemistry, 283(7), 3846-3853 (2007-12-14)
Notch signaling constitutes an evolutionarily conserved mechanism that mediates cell-cell interactions in various developmental processes. Numerous regulatory proteins interact with the Notch receptor and its ligands and control signaling at multiple levels. Ubiquitination and endocytosis followed by endosomal sorting of
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