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U4127

Urocortin human

Name: Urocortin human
Brand: SIGMA

≥85% (HPLC), powder

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关于此项目

经验公式（希尔记法）:

C₂₀₄H₃₃₇N₆₃O₆₄

化学文摘社编号:

176591-49-4

分子量:

4696.24

UNSPSC Code:

12352200

NACRES:

NA.32

MDL number:

MFCD00802621

Form:

powder

Assay:

≥85% (HPLC)

Biological source:

human

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属性

biological source

human

Quality Segment

200

assay

≥85% (HPLC)

form

powder

technique(s)

ligand binding assay: suitable

UniProt accession no.

P55089

storage temp.

−20°C

Gene Information

human ... UCN(7349)

说明

Application

Urocortin human can be used as a test compound for studying the impact of corticotropin-releasing factor (CRF) receptor agonist and antagonist on sleep-wake patterns in conscious rats by using radiotelemetry system.

Biochem/physiol Actions

Urocortin is a CRF-related neuropeptide having high affinity for CRF2 receptor possess appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.

Binds to CRF receptor types 1, 2α, and 2β.

Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.

存储类别

11 - Combustible Solids

怎么回事？

WGK 3

闪点 (F)

Not applicable

闪点 (°C)

Not applicable

PPE（个人防护设备）

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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