U4127
Urocortin human
≥85% (HPLC), powder
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关于此项目
经验公式（希尔记法）:
C204H337N63O64
化学文摘社编号:
分子量:
4696.24
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
Form:
powder
Assay:
≥85% (HPLC)
Biological source:
human
Application
Urocortin human can be used as a test compound for studying the impact of corticotropin-releasing factor (CRF) receptor agonist and antagonist on sleep-wake patterns in conscious rats by using radiotelemetry system.
Biochem/physiol Actions
Binds to CRF receptor types 1, 2α, and 2β.
Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.
Urocortin is a CRF-related neuropeptide having high affinity for CRF2 receptor possess appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)