U4133
URB597
≥98% (HPLC), fatty acid amide hydrolase (FAAH) inhibitor, powder
别名:
Cyclohexylcarbamic acid 3´-carbamoyl-biphenyl-3-yl ester
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关于此项目
经验公式（希尔记法）:
C20H22N2O3
化学文摘社编号:
分子量:
338.40
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
URB597, ≥98% (HPLC), powder
SMILES string
NC(=O)c1cccc(c1)-c2cccc(OC(=O)NC3CCCCC3)c2
InChI key
ROFVXGGUISEHAM-UHFFFAOYSA-N
InChI
1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)
description
Drug Control: Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet.
assay
≥98% (HPLC)
form
powder
drug control
Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
color
white
solubility
DMSO: soluble ~14 mg/mL
storage temp.
2-8°C
Quality Level
相关类别
General description
URB597 binds to active sites of fatty acid amide hydrolases and inhibits their activity. URB597 alters expression of tyrosine hydroxylase and interacts with abnormal-cannabidiol (Abn-CBD) and peroxisome proliferator-activated receptors (PPARs). URB597 elicits antinociception property via cannabinoid receptor by maintaining endocannabinoid anandamide (AEA) levels. URB597 reduces abnormal hyperactivity in neurons and could be for treatment of seizures and improving synaptic plasticity.
Biochem/physiol Actions
Potent, selective fatty acid amide hydrolase (FAAH) inhibitor.
Preparation Note
URB597 is soluble in DMSO at a concentration that is approximately 14 mg/ml.
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves
Lucas Albrechet-Souza et al.
Neurobiology of stress, 15, 100387-100387 (2021-09-16)
Understanding sex differences in behavioral and molecular effects of stress has important implications for understanding the vulnerability to chronic psychiatric disorders associated with stress response circuitry. The amygdala is critical for emotional learning and generating behavioral responses to stressful stimuli
Effects of the fatty acid amide hydrolase (FAAH) inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats
Kwilasz AJ, et al.
Behavioural Pharmacology, 25(2), 119-119 (2014)
The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity
Colangeli R, et al.
Scientific Reports, 7(1), 11152-11152 (2017)
Interaction between the cholecystokinin and endogenous cannabinoid systems in cued fear expression and extinction retention
Bowers ME and Ressler KJ
Neuropsychopharmacology, 30, 688-688 (2015)
The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB1-and FAAH-independent mechanisms
Bosier B, et al.
British Journal of Pharmacology, 169(4), 794-807 (2013)
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