U6628
乌发醇
≥95%
别名:
Urs-12-ene-3,28-diol
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关于此项目
经验公式（希尔记法）:
C30H50O2
化学文摘社编号:
分子量:
442.72
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352103
EC Number:
208-888-3
MDL number:
InChI
1S/C30H50O2/c1-19-10-15-30(18-31)17-16-28(6)21(25(30)20(19)2)8-9-23-27(5)13-12-24(32)26(3,4)22(27)11-14-29(23,28)7/h8,19-20,22-25,31-32H,9-18H2,1-7H3/t19-,20+,22+,23-,24+,25+,27+,28-,29-,30-/m1/s1
InChI key
XUARCIYIVXVTAE-ZAPOICBTSA-N
SMILES string
C[C@@H]1CC[C@]2(CO)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C
assay
≥95%
mp
223-225 °C (lit.)
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
Quality Level
Gene Information
mouse ... Nos2(18126)
General description
Uvaolis是一种五环三萜化合物，通常从植物叶子中提取，例如罗布麻 (Apocynum venetum L.)、橄榄叶 (Olea europaea L.) 和牛至 (Origanum vulgare L.)。
Application
熊果醇已被用作视黄酸受体相关孤儿受体γ t (RORγt) 抑制剂，以研究强心苷还原酶2 (Cgr2) 对其代谢的作用。
Biochem/physiol Actions
熊果醇具有抗氧化、抗癌、抗炎和伤口愈合等药理特性。它还具有血管扩张、保肝和抗菌作用。熊果醇对一氧化氮 (NO) 释放具有抑制作用。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Guang-Bo Xie et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 32(18), 1890-1892 (2007-12-07)
To investigate the chemical constituents of Ilex pernyi. The chemical constituents were isolated by various column chromatographic methods. The structures were identified by spectral data. Eight triterpenoid compounds were isolated and identified as ursolic acid (1), lupeol (2), alpha-amyrin (3)
A Martins et al.
International journal of antimicrobial agents, 37(5), 438-444 (2011-03-18)
Several compounds isolated from the plant Carpobrotus edulis were evaluated for their activity against multidrug-resistant (MDR) bacteria and their efflux pump systems. Amongst the compounds isolated, six compounds were tested, namely uvaol, β-amyrin, oleanolic acid, catechin, epicatechin and monogalactosyldiacylglycerol. Oleanolic
Julianderson Carmo et al.
Molecules (Basel, Switzerland), 25(21) (2020-11-01)
Uvaol is a natural pentacyclic triterpene that is widely found in olives and virgin olive oil, exerting various pharmacological properties. However, information remains limited about how it affects fibroblasts and endothelial cells in events associated with wound healing. Here, we
Margaret Alexander et al.
Cell host & microbe, 30(1), 17-30 (2021-11-26)
Bacterial activation of T helper 17 (Th17) cells exacerbates mouse models of autoimmunity, but how human-associated bacteria impact Th17-driven disease remains elusive. We show that human gut Actinobacterium Eggerthella lenta induces intestinal Th17 activation by lifting inhibition of the Th17
L I Somova et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 11(2-3), 121-129 (2004-04-09)
The cardiotonic and antidysrhythmic effects of four triterpenoid derivatives, namely oleanolic acid (OA), ursolic acid (UA), and uvaol (UV), isolated from the leaves of African wild olive (Olea europaea, subsp. africana) as well as methyl maslinate (MM) isolated from the
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