UC178
(±)-Nirvanol
别名:
(±)-5-Ethyl-5-phenyl-2,4-imidazolidinedione, (±)-5-Ethyl-5-phenylhydantoin
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关于此项目
经验公式（希尔记法）:
C11H12N2O2
化学文摘社编号:
分子量:
204.23
UNSPSC Code:
12161501
PubChem Substance ID:
MDL number:
InChI
1S/C11H12N2O2/c1-2-11(8-6-4-3-5-7-8)9(14)12-10(15)13-11/h3-7H,2H2,1H3,(H2,12,13,14,15)
SMILES string
CCC1(NC(=O)NC1=O)c2ccccc2
InChI key
UDTWZFJEMMUFLC-UHFFFAOYSA-N
form
solid
color
off-white
solubility
acetone: soluble
ethanol: soluble
methanol: soluble
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
CYP2B6 N-demethyl metabolite of (±)-mephenytoin; anticonvulsive; hypnotic
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Preparation Note
(±)-Nirvanol is soluble in methanol, acetone and ethanol.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
H Heyn et al.
Drug metabolism and disposition: the biological fate of chemicals, 24(9), 948-954 (1996-09-01)
In vitro methods were used to identify the cytochrome P450 (CYP) enzyme(s) involved in S-mephenytoin N-demethylation. S-Mephenytoin (200 microM) was incubated with human liver microsomes, and nirvanol formation was quantitated by reversed-phase HPLC. S-Mephenytoin N-demethylase activity in a panel of
J W Ko et al.
Drug metabolism and disposition: the biological fate of chemicals, 26(8), 775-778 (1998-08-11)
We tested the ability of human liver microsomes (HLMs) and recombinant human cytochrome P450 (CYP or P450) isoforms to catalyze the N-demethylation of nirvanol-free (S)-mephenytoin [(S)-MP] in vitro. In mixed HLMs, the kinetics of (S)-MP N-demethylation suggested two contributing activities.
R W Nims et al.
Chemical research in toxicology, 6(2), 188-196 (1993-03-01)
The pharmacodynamics of rat hepatic cytochrome P450 2B (P450 2B) induction by phenobarbital (PB) and two structural congeners, dl-5-ethyl-5-phenylhydantoin (EPH) and dl-5-ethyl-5-phenyloxazolidinedione (EPO), were investigated. The in vivo induction of P450 2B was probed in F344/NCr rats by measuring immunoreactive
R W Nims et al.
Journal of biochemical toxicology, 9(6), 279-288 (1994-12-01)
To explore the enantioselectivity of ligand interaction with the putative phenobarbital receptor, the pharmacodynamics of cytochrome P450 2B (CYP2B) induction by racemic 5-ethyl-5-phenylhydantoin and its two enantiomers were investigated in the male F344/NCr rat and in cultured adult male rat
R W Nims et al.
Journal of biochemical toxicology, 9(5), 269-278 (1994-10-01)
The abilities of structural congeners of phenobarbital to induce immunoreactive hepatic cytochrome P450 2B (CYP2B) protein and associated catalytic activity (benzyloxyresorufin O-dealkylation) in the male B6C3F1 mouse were examined. Interspecies differences in inducing ability were examined through comparison of the
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