WH0221037M3
Monoclonal Anti-JMJD1C antibody produced in mouse
clone 5F12, purified immunoglobulin, buffered aqueous solution
别名:
Anti-DKFZp761F0118, Anti-FLJ14374, Anti-KIAA1380, Anti-RP1110C13.2, Anti-TRIP8, Anti-jumonji domain containing 1C
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
5F12, monoclonal
Application:
ELISA (i), IHC (p), WB
Citations:
5
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
5F12, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, indirect ELISA: suitable, western blot: 1-5 μg/mL
isotype
IgG2aκ
GenBank accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... JMJD1C(221037)
General description
Jumonji domain containing 1C (JMJD1C) belongs to the lysine demethylase 3 family and maybe a histone demethylase. The gene encoding it is localized on human chromosome 10q21.3.
Immunogen
JMJD1C (NP_004232, 2 a.a. ~ 99 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
IVMNDQVLEPQNVDPSMVQMTFLDDVVHSLLKGENIGITSRRRSRANQNVNAVHSHYTRAQANSPRPAMNSQAAVPKQNTHQQQQQRSIRPNKRKGSD
Sequence
IVMNDQVLEPQNVDPSMVQMTFLDDVVHSLLKGENIGITSRRRSRANQNVNAVHSHYTRAQANSPRPAMNSQAAVPKQNTHQQQQQRSIRPNKRKGSD
Biochem/physiol Actions
Jumonji domain containing 1C (JMJD1C) takes part in DNA-damage repair. It is a coactivator of the androgen receptor and also associates with the thyroid receptor. JMJD1C activates a transcription factor involved in acute myeloid leukemia. It has been linked to fatty liver disease and thyroiditis.
Physical form
Solution in phosphate buffered saline, pH 7.4
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Mo Chen et al.
Genes & development, 29(20), 2123-2139 (2015-10-24)
RUNX1-RUNX1T1 (formerly AML1-ETO), a transcription factor generated by the t(8;21) translocation in acute myeloid leukemia (AML), dictates a leukemic program by increasing self-renewal and inhibiting differentiation. Here we demonstrate that the histone demethylase JMJD1C functions as a coactivator for RUNX1-RUNX1T1
Seung Hoan Choi et al.
PLoS genetics, 12(2), e1005874-e1005874 (2016-02-26)
Vascular endothelial growth factor (VEGF) is an angiogenic and neurotrophic factor, secreted by endothelial cells, known to impact various physiological and disease processes from cancer to cardiovascular disease and to be pharmacologically modifiable. We sought to identify novel loci associated
Rajkumar Dorajoo et al.
Genes & nutrition, 10(6), 53-53 (2015-11-21)
Polyunsaturated fatty acids (PUFAs) have a major impact on human health. Recent genome-wide association studies (GWAS) have identified several genetic loci that are associated with plasma levels of n-3 and n-6 PUFAs in primarily subjects of European ancestry. However, the
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| 货号 | GTIN |
|---|---|
| WH0221037M3-100UG | 04061829605414 |