WH0221037M3
Monoclonal Anti-JMJD1C antibody produced in mouse
clone 5F12, purified immunoglobulin, buffered aqueous solution
别名:
Anti-DKFZp761F0118, Anti-FLJ14374, Anti-KIAA1380, Anti-RP1110C13.2, Anti-TRIP8, Anti-jumonji domain containing 1C
登录 查看组织和合同定价。
选择尺寸
关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
5F12, monoclonal
Application:
ELISA (i), IHC (p), WB
Citations:
5
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
5F12, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, indirect ELISA: suitable, western blot: 1-5 μg/mL
isotype
IgG2aκ
GenBank accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... JMJD1C(221037)
正在寻找类似产品? 访问 产品对比指南
General description
Jumonji domain containing 1C (JMJD1C) belongs to the lysine demethylase 3 family and maybe a histone demethylase. The gene encoding it is localized on human chromosome 10q21.3.
Immunogen
JMJD1C (NP_004232, 2 a.a. ~ 99 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
IVMNDQVLEPQNVDPSMVQMTFLDDVVHSLLKGENIGITSRRRSRANQNVNAVHSHYTRAQANSPRPAMNSQAAVPKQNTHQQQQQRSIRPNKRKGSD
Sequence
IVMNDQVLEPQNVDPSMVQMTFLDDVVHSLLKGENIGITSRRRSRANQNVNAVHSHYTRAQANSPRPAMNSQAAVPKQNTHQQQQQRSIRPNKRKGSD
Biochem/physiol Actions
Jumonji domain containing 1C (JMJD1C) takes part in DNA-damage repair. It is a coactivator of the androgen receptor and also associates with the thyroid receptor. JMJD1C activates a transcription factor involved in acute myeloid leukemia. It has been linked to fatty liver disease and thyroiditis.
Physical form
Solution in phosphate buffered saline, pH 7.4
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Rajkumar Dorajoo et al.
Genes & nutrition, 10(6), 53-53 (2015-11-21)
Polyunsaturated fatty acids (PUFAs) have a major impact on human health. Recent genome-wide association studies (GWAS) have identified several genetic loci that are associated with plasma levels of n-3 and n-6 PUFAs in primarily subjects of European ancestry. However, the
Mo Chen et al.
Genes & development, 29(20), 2123-2139 (2015-10-24)
RUNX1-RUNX1T1 (formerly AML1-ETO), a transcription factor generated by the t(8;21) translocation in acute myeloid leukemia (AML), dictates a leukemic program by increasing self-renewal and inhibiting differentiation. Here we demonstrate that the histone demethylase JMJD1C functions as a coactivator for RUNX1-RUNX1T1
Seung Hoan Choi et al.
PLoS genetics, 12(2), e1005874-e1005874 (2016-02-26)
Vascular endothelial growth factor (VEGF) is an angiogenic and neurotrophic factor, secreted by endothelial cells, known to impact various physiological and disease processes from cancer to cardiovascular disease and to be pharmacologically modifiable. We sought to identify novel loci associated
Daniela Kurfurstova et al.
Molecular oncology, 10(6), 879-894 (2016-03-19)
The DNA damage checkpoints provide an anti-cancer barrier in diverse tumour types, however this concept has remained unexplored in prostate cancer (CaP). Furthermore, targeting DNA repair defects by PARP1 inhibitors (PARPi) as a cancer treatment strategy is emerging yet requires
Nan Zhu et al.
The Journal of clinical investigation, 126(3), 997-1011 (2016-02-16)
Self-renewal is a hallmark of both hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs); therefore, the identification of mechanisms that are required for LSC, but not HSC, function could provide therapeutic opportunities that are more effective and less toxic
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持