X103
Xanthine amine congener
≥96% (HPLC)
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关于此项目
经验公式（希尔记法）:
C21H28N6O4
化学文摘社编号:
分子量:
428.48
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C21H28N6O4/c1-3-11-26-19-17(20(29)27(12-4-2)21(26)30)24-18(25-19)14-5-7-15(8-6-14)31-13-16(28)23-10-9-22/h5-8H,3-4,9-13,22H2,1-2H3,(H,23,28)(H,24,25)
SMILES string
CCCN1C(=O)N(CCC)c2nc([nH]c2C1=O)-c3ccc(OCC(=O)NCCN)cc3
InChI key
FIQGIOAELHTLHM-UHFFFAOYSA-N
assay
≥96% (HPLC)
form
solid
color
white
solubility
DMSO: >5 mg/mL
storage temp.
room temp
Gene Information
human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316), Adora3(25370)
Biochem/physiol Actions
Xanthine amine congener is a potent, nonselective adenosine receptor antagonist (A1 and A2B > A2A).
Features and Benefits
This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
S Boehm
Naunyn-Schmiedeberg's archives of pharmacology, 350(5), 454-458 (1994-11-01)
The effects of ATP and analogues on the release of previously incorporated 3H-noradrenaline were studied in cultured sympathetic neurons derived from superior cervical ganglia of neonatal rats. Electrical field stimulation (40 mA at 3 Hz) of the neurons for 10
Q Jiang et al.
Journal of medicinal chemistry, 40(16), 2588-2595 (1997-08-01)
Structure-affinity relationships for ligand binding at the human A2A adenosine receptor have been probed using site-directed mutagenesis in the transmembrane helical domains (TMs). The mutant receptors were expressed in COS-7 cells and characterized by binding of the radioligands [3H]CGS21680, [3H]NECA
D K Von Lubitz et al.
European journal of pharmacology, 263(1-2), 59-67 (1994-09-22)
Chronic treatment with the selective adenosine A3 receptor agonist N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide (IB-MECA) administered prior to either 10 or 20 min forebrain ischemia in gerbils resulted in improved postischemic cerebral blood circulation, survival, and neuronal preservation. Opposite effects, i.e., impaired postischemic blood
S J Briddon et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(13), 4673-4678 (2004-04-09)
The A1-adenosine receptor (A1-AR) is a G protein-coupled receptor that mediates many of the physiological effects of adenosine in the brain, heart, kidney, and adipocytes. Currently, ligand interactions with the A1-AR can be quantified on large cell populations only by
U Prabhakar et al.
International journal of immunopharmacology, 17(3), 221-224 (1995-03-01)
We examined the effects of adenosine A1 and A2 receptor agonists on LPS-stimulated TNF alpha production by human monocytes isolated from peripheral blood. We have demonstrated that CGS-21680, a highly selective A2 agonist inhibited production of TNF alpha at the
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