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Merck
CN

X4626

XTT 钠盐

powder, BioReagent, suitable for cell culture

别名:

2,3-双(2-甲氧基-4-硝基-5-磺苯基)-2H-四氮唑-5-甲酰苯胺 内盐

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关于此项目

经验公式（希尔记法）:
C22H16N7NaO13S2
化学文摘社编号:
111072-31-2
分子量:
673.52
NACRES:
NA.75
PubChem Substance ID:
24902150
UNSPSC Code:
12352207
MDL number:
MFCD00083517

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产品名称

XTT 钠盐, powder, BioReagent, suitable for cell culture

InChI

1S/C22H17N7O13S2.Na/c1-41-17-8-15(28(31)32)19(43(35,36)37)10-13(17)26-24-21(22(30)23-12-6-4-3-5-7-12)25-27(26)14-11-20(44(38,39)40)16(29(33)34)9-18(14)42-2;/h3-11H,1-2H3,(H2-,23,30,35,36,37,38,39,40);/q;+1/p-1

SMILES string

[Na+].COc1cc(c(cc1-n2nc(n[n+]2-c3cc(c(cc3OC)[N+]([O-])=O)S([O-])(=O)=O)C(=O)Nc4ccccc4)S([O-])(=O)=O)[N+]([O-])=O

InChI key

JACYMBNQPPWQML-UHFFFAOYSA-M

product line

BioReagent

assay

≥90%

form

powder

storage condition

dry at room temperature

technique(s)

cell culture | mammalian: suitable
protein quantification: suitable

application(s)

detection

detection method

colorimetric

storage temp.

2-8°C

Quality Level

200

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Application

XTT可与吩嗪硫酸甲酯（PMS）联合使用，用于筛选人肿瘤细胞系。 四唑染料也被用于真菌细胞损伤研究 、葡萄球菌的抗菌敏感性测试，以及念珠菌生物膜研究。XTT检测法的局限性也有报道。
XTT钠盐已用于评估细胞活性。

Biochem/physiol Actions

XTT（3′-[1-[(苯胺基)-羰基]-3,4-四唑]-双(4-甲氧基-6-硝基)苯-磺酸钠）受到代谢活性细胞中存在的脱氢酶的作用。这可产生水溶性甲臜，是一种颜色很深的产物。因为产物是可溶的，不会形成甲臜结晶，这一点与MTT相反，因此XTT在细胞增殖比色法检测中更具优势。
在活细胞中，XTT被代谢还原，生成可比色的水溶性甲臜产物。

General description

XTT（3′-[1-[(苯胺基)-羰基]-3,4-四唑]-双(4-甲氧基-6-硝基)苯-磺酸钠）是一种四唑盐，在生物还原时可生成水溶性甲臜。

pictograms

Flame
GHS02

signalword

Danger

hcodes

H242

Hazard Classifications

Self-react. C

supp_hazards

EUH044

存储类别

4.1A - Other explosive hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000393703
0000375596
0000343253
0000343254
0000375596

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Microbes develop several strategies to survive in the adverse condition such as biofilm formation, attaining non-dividing state, altering drug target or drug, thereby increases the burden of drug dosage. To combat these issues, nanoparticles have shown an alternative approach for
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