X4626
XTT 钠盐
powder, BioReagent, suitable for cell culture
别名:
2,3-双(2-甲氧基-4-硝基-5-磺苯基)-2H-四氮唑-5-甲酰苯胺 内盐
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关于此项目
经验公式（希尔记法）:
C22H16N7NaO13S2
CAS Number:
分子量:
673.52
MDL编号:
UNSPSC代码:
12352207
PubChem化学物质编号:
NACRES:
NA.75
产品线
BioReagent
质量水平
方案
≥90%
表单
powder
储存条件
dry at room temperature
技术
cell culture | mammalian: suitable
protein quantification: suitable
应用
detection
检测方法
colorimetric
储存温度
2-8°C
SMILES字符串
[Na+].COc1cc(c(cc1-n2nc(n[n+]2-c3cc(c(cc3OC)[N+]([O-])=O)S([O-])(=O)=O)C(=O)Nc4ccccc4)S([O-])(=O)=O)[N+]([O-])=O
InChI
1S/C22H17N7O13S2.Na/c1-41-17-8-15(28(31)32)19(43(35,36)37)10-13(17)26-24-21(22(30)23-12-6-4-3-5-7-12)25-27(26)14-11-20(44(38,39)40)16(29(33)34)9-18(14)42-2;/h3-11H,1-2H3,(H2-,23,30,35,36,37,38,39,40);/q;+1/p-1
InChI key
JACYMBNQPPWQML-UHFFFAOYSA-M
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一般描述
XTT（3′-[1-[(苯胺基)-羰基]-3,4-四唑]-双(4-甲氧基-6-硝基)苯-磺酸钠）是一种四唑盐，在生物还原时可生成水溶性甲臜。
应用
XTT可与吩嗪硫酸甲酯（PMS）联合使用，用于筛选人肿瘤细胞系。 四唑染料也被用于真菌细胞损伤研究 、葡萄球菌的抗菌敏感性测试，以及念珠菌生物膜研究。XTT检测法的局限性也有报道。
XTT钠盐已用于评估细胞活性。
生化/生理作用
XTT（3′-[1-[(苯胺基)-羰基]-3,4-四唑]-双(4-甲氧基-6-硝基)苯-磺酸钠）受到代谢活性细胞中存在的脱氢酶的作用。这可产生水溶性甲臜，是一种颜色很深的产物。因为产物是可溶的，不会形成甲臜结晶，这一点与MTT相反，因此XTT在细胞增殖比色法检测中更具优势。
在活细胞中，XTT被代谢还原，生成可比色的水溶性甲臜产物。
警示用语：
Danger
危险声明
危险分类
Self-react. C
补充剂危害
储存分类代码
4.1A - Other explosive hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
L M Jost et al.
Journal of immunological methods, 147(2), 153-165 (1992-03-04)
A tetrazolium compound, XTT, bioreducible to a water-soluble formazan was used to develop a simplified cellular cytotoxicity assay. Most (13/15 melanoma and 2/3 colon carcinoma cell lines tested metabolized XTT greater than 50 times more efficiently than the lymphoid effector
Amos C Hung et al.
Oncology letters, 22(5), 774-774 (2021-10-01)
Esophageal cancer is one of the most common malignancies and leading cause of cancer-associated mortality worldwide. However, the molecular mechanisms underlying esophageal cancer progression and the development of clinical tools for effective diagnosis remain unclear. Resistin, which was originally identified
Antimicrobial activity, cytotoxicity and chemical analysis of lemongrass essential oil (Cymbopogon flexuosus) and pure citral
Adukwu EC, et al.
Applied Microbiology and Biotechnology, 100(22), 9619-9627 (2016)
Sristy Shikha et al.
Scientific reports, 10(1), 1463-1463 (2020-01-31)
Microbes develop several strategies to survive in the adverse condition such as biofilm formation, attaining non-dividing state, altering drug target or drug, thereby increases the burden of drug dosage. To combat these issues, nanoparticles have shown an alternative approach for
Jesús Gandara-Loe et al.
ACS applied materials & interfaces, 11(2), 1924-1931 (2018-12-19)
Metal-organic frameworks (MOFs) have been evaluated as potential nanocarriers for intraocular incorporation of brimonidine tartrate to treat chronic glaucoma. Experimental results show that UiO-67 and MIL-100 (Fe) exhibit the highest loading capacity with values up to 50-60 wt %, whereas
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