X4753
XCT790
≥98% (HPLC), ERRα agonist, solid
别名:
3-[4-（2,4-双-三氟甲基苄氧基）-3-甲氧基苯基]-2-氰基-N-（5-三氟甲基-1,3,4-噻二唑-2-基）丙烯酰胺
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关于此项目
经验公式（希尔记法）:
C23H13F9N4O3S
化学文摘社编号:
分子量:
596.42
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
XCT790, ≥98% (HPLC), solid
Quality Level
assay
≥98% (HPLC)
form
solid
color
yellow
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
SMILES string
COc1cc(ccc1OCc2ccc(cc2C(F)(F)F)C(F)(F)F)\C=C(/C#N)C(=O)Nc3nnc(s3)C(F)(F)F
InChI
1S/C23H13F9N4O3S/c1-38-17-7-11(6-13(9-33)18(37)34-20-36-35-19(40-20)23(30,31)32)2-5-16(17)39-10-12-3-4-14(21(24,25)26)8-15(12)22(27,28)29/h2-8H,10H2,1H3,(H,34,36,37)/b13-6+
InChI key
HQFNFOOGGLSBBT-AWNIVKPZSA-N
相关类别
Application
XCT790已被用于：
- 在C2C12肌管中作为雌激素相关受体（ERR）α 的反向激动剂
- 作为雌激素相关受体（ERR）α 反向激动剂以阐明ERR的蜕膜功能α 子宫内膜胚胎干细胞中
- 作为人类神经母细胞瘤SH-SY5Y和HeLa细胞系中的自噬诱导剂。
Biochem/physiol Actions
XCT 790是一种5′腺苷单磷酸激活蛋白激酶（AMPK）激活剂。它还可充当线粒体中的质子离子载体和氧化磷酸化的解偶联剂。XCT790会破坏血管内皮生长因子（VEGF）和血管生成素2（Ang-2）的表达，并通过雌激素相关受体（ERRα）抑制表现出对子宫内膜肿瘤的抑制作用。XCT790可介导细胞周期停滞并促进三阴性乳腺癌（TNBC）的凋亡。
XCT790 是一种强效、特异性的 ERRα 反向激动剂。XCT790 具有选择性，在浓度低于 10 μM 时，对相关核受体（如 ERRγ 或 ERα）无明显拮抗活性。在使用 GAL4-ERR LBD 或全长 ERR 和 mSHP 启动子的瞬时转染试验中，IC 50 值为 300-500 nM。
XCT790 是一种强效、特异性的 ERRα 反向激动剂。选择性；在 10 μM 以下浓度时，对相关核受体，如 ERRγ 或 ERα 显示无明显拮抗活性。
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 4
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Rasmus J O Sjögren et al.
Diabetologia, 64(9), 2077-2091 (2021-06-17)
Increased levels of branched-chain amino acids (BCAAs) are associated with type 2 diabetes pathogenesis. However, most metabolomic studies are limited to an analysis of plasma metabolites under fasting conditions, rather than the dynamic shift in response to a metabolic challenge.
Ying-Min Wu et al.
Oncotarget, 7(11), 12568-12581 (2016-02-13)
There is an urgent clinical need for targeted therapy approaches for triple-negative breast cancer (TNBC) patients. Increasing evidences suggested that the expression of estrogen-related receptor alpha (ERRα) was correlate with unfavorable clinical outcomes of breast cancer patients. We here show
PengMing Sun et al.
Cancer management and research, 10, 2521-2535 (2018-08-22)
To explore the targeted therapy of estrogen-related receptor α (ERRα) in endometrial cancer (EC) cells and its potential mechanisms. The mRNA and protein expression levels of ERRα and estrogen receptor α (ERα) were detected by qPCR and Western blotting in
Banu Eskiocak et al.
Biochemistry, 53(29), 4839-4846 (2014-07-08)
XCT 790 is widely used to inhibit estrogen-related receptor α (ERRα) activity as an inverse agonist. Here, we report that XCT 790 potently activates AMP kinase (AMPK) in a dose-dependent and ERRα-independent manner, with active concentrations more than 25-fold below
Zhenyu Xu et al.
Theranostics, 10(9), 4201-4216 (2020-04-01)
Enhanced intratumoral androgen biosynthesis and persistent androgen receptor (AR) signaling are key factors responsible for the relapse growth of castration-resistant prostate cancer (CRPC). Residual intraprostatic androgens can be produced by de novo synthesis of androgens from cholesterol or conversion from
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| X4753-25MG | 04061833274873 |
| X4753-5MG | 04061837549762 |
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