Z0127
Zatebradine hydrochloride
≥98% (HPLC), HCN channel blocker, powder
别名:
7,8-Dimethoxy-3-[3-[-N-[2-(3,4 dimethoxyphenyl)ethyl]-N-methylamino]propyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride, UL-FS49
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关于此项目
经验公式（希尔记法）:
C26H37ClN2O5
化学文摘社编号:
分子量:
493.04
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
Zatebradine hydrochloride, ≥98% (HPLC), powder
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white
溶解性
H2O: >10 mg/mL
创始人
Boehringer Ingelheim
储存温度
2-8°C
SMILES字符串
Cl[H].COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC
InChI
1S/C26H36N2O5.ClH/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29;/h7-8,15-17H,6,9-14,18H2,1-5H3;1H
InChI key
ZRNKXJHEQKMWCH-UHFFFAOYSA-N
相关类别
应用
Zatebradine hydrochloride has been used:
- as an If blocker to study its effects on cardiomyocyte clusters (CMCs)
- as a hyperpolarization-activated and cyclic nucleotide-gated (HCN) channel inhibitor to study its effects on viability of degenerating rod or cone photoreceptors in mice
- as a bradycardiac agent to study its effects on tachycardia and elevated temperature in fish
生化/生理作用
HCN channel blocker: blocker of neuronal Ih, related cardiac If channels and ATP-sensitive Kir channels.
Zatebradine is a bradycardiac agent.
特点和优势
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Marco Michi et al.
Bioanalysis, 2(11), 1863-1871 (2010-11-19)
One of the main reasons for the increased popularity of dried blood spots (DBS) is related to the 3Rs principles (replacement, refinement and reduction) for animal use in drug development. The small blood volume collected using this technique may have
M De Pauw et al.
Basic research in cardiology, 99(5), 360-371 (2004-09-01)
Myocardial contractility is regulated by adrenergic stimulation, the strength-length relationship and the force-frequency relationship or Bowditch effect. The latter mechanism was clearly demonstrated in muscle strips, in the isolated heart as well as in in-vivo experiments. The aim of this
Eugene Nalivaiko et al.
Physiology & behavior, 96(2), 320-327 (2008-11-11)
The aim of this study was to apply a behavioural stress paradigm for studying the neural mechanisms underlying stress-induced arrhythmias, and to test whether such arrhythmias could be suppressed by systemic administration of 8-OH-DPAT, a 5-HT1A agonist possessing central sympatholytic
Toshihiko Ogura et al.
Vision research, 43(19), 2019-2028 (2003-07-05)
The different actions of two I(h) channel blockers, zatebradine (UL-FS 49) and ZD7288, on rod photoresponses were analysed by computer simulation using a newly revised ionic current model of the rod photoreceptor, based on Hodgkin-Huxley equations. The model, adjusted to
Annette Hellbach et al.
Journal of experimental zoology. Part A, Ecological genetics and physiology, 315(8), 476-486 (2011-07-20)
Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels generate the rhythmic beating of mammalian hearts. We identified an HCN homolog in the colonial ascidian Botryllus schlosseri, a nonvertebrate chordate which possesses a tubular heart that beats bidirectionally. Contractions initiate at one end of
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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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