Z1252
Zofenopril calcium
>98% (HPLC), powder
别名:
(4S)-1-[(2S)-3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-L-proline calcium salt
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关于此项目
经验公式（希尔记法）:
C22H22NO4S2 · 0.5Ca
化学文摘社编号:
分子量:
448.58
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/2C22H23NO4S2.Ca/c2*1-15(14-28-22(27)16-8-4-2-5-9-16)20(24)23-13-18(12-19(23)21(25)26)29-17-10-6-3-7-11-17;/h2*2-11,15,18-19H,12-14H2,1H3,(H,25,26);/q;;+2/p-2/t2*15-,18+,19+;/m11./s1
SMILES string
[Ca++].C[C@H](CSC(=O)c1ccccc1)C(=O)N2C[C@H](C[C@H]2C([O-])=O)Sc3ccccc3.C[C@H](CSC(=O)c4ccccc4)C(=O)N5C[C@H](C[C@H]5C([O-])=O)Sc6ccccc6
InChI key
NSYUKKYYVFVMST-LETVYOFWSA-L
assay
>98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >5 mg/mL
originator
Bristol-Myers Squibb
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Zofenopril is a long-lasting, lipophilic ACE inhibitor. Zofenopril is also an inhibitor of PEPT2, the predominant peptide transporter in kidney and choroid plexus.
Zofenopril is an angiotensin-converting enzyme (ACE) inhibitor and a PEPT2 inhibitor.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Claudio Borghi et al.
Clinical cardiology, 35(7), 416-423 (2012-06-19)
Angiotensin-converting enzyme inhibitors (ACEIs) are largely employed for treating patients with left ventricular dysfunction (LVD), but their efficacy may be negatively affected by concomitant administration of acetylsalicylic acid (ASA), with some difference among the different compounds. The interaction between ASA
Cecilia Cialdai et al.
Naunyn-Schmiedeberg's archives of pharmacology, 382(5-6), 455-461 (2010-09-18)
Dry and persistent cough is one of the commonest side effects experienced by patients treated with angiotensin-converting enzyme (ACE) inhibitors for the therapy of hypertension and congestive heart failure. The present study investigated the effect of zofenopril and ramipril on
Stefano Omboni et al.
Cardiovascular therapeutics, 27(4), 275-288 (2009-10-17)
Zofenopril, is a highly lipophilic ACE inhibitor, characterized by long-lasting tissue penetration and sustained cardiac ACE inhibition, indicated for the treatment of hypertension and myocardial infarction. Comparative studies with different antihypertensive drug classes have demonstrated the good efficacy and tolerability
Bülent Altunoluk et al.
Urology journal, 8(4), 313-319 (2011-11-18)
To investigate the protective effect of zofenopril on torsion/detorsion-induced biochemical and histopathological changes in experimental testicular ischemia or reperfusion injury in rats. A total of 35 prepubertal male Wistar-Albino rats were divided into five groups, including 7 rats in each
Giuseppe Sacco et al.
Vascular pharmacology, 50(5-6), 166-170 (2009-04-07)
The angiotensin converting enzyme inhibitor zofenopril has been shown to possess cardioprotective effects toward myocardial damage induced by chronic doxorubicin treatment in the rat. In the present study we have investigated the relationship between cardioprotection exerted by 2 angiotensin converting
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