V003170
没食子酸
puriss., 98.0%
别名:
3,4,5-三羟基苯甲酸
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线性分子式:
(HO)3C6H2CO2H
化学文摘社编号:
分子量:
170.12
EC Number:
205-749-9
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
2050274
InChI
1S/C7H6O5/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1-2,8-10H,(H,11,12)
InChI key
LNTHITQWFMADLM-UHFFFAOYSA-N
SMILES string
OC(=O)c1cc(O)c(O)c(O)c1
grade
puriss.
assay
98.0%
mp
251 °C (dec.) (lit.)
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Biochem/physiol Actions
没食子酸是一种水溶性酚酸，存在于葡萄和许多植物的叶子中。 没食子酸酯，如单宁、儿茶素没食子酸酯和脂肪族没食子酸酯，是有效的 体外抗氧化剂。 但是，没食子酸本身在 体外也具有抗氧化、抗癌和抗血管生成活性。
Gallic acid has an ability to induce apoptosis in promyelocytic leukemia HL-60RG cells. In addition, it also exhibits anti- inflammatory, anti-microbial and radical scavenging activities in- vitro. Gallic acid prevents mast cell-derived inflammatory allergic reactions by inhibiting histamine secretion and pro-inflammatory cytokine expression. Thus, this phenolic acid can be used as a potent therapeutic to treat inflammatory allergic diseases.
Gallic acid is a water soluble phenolic acid present in grapes and in the leaves of many plants. Gallic acid esters, such as tannins, catechin gallates and aliphatic gallates are potent antioxidants in vitro. However, gallic acid itself also appears to have antioxidant, anticarcinogenic and antiangiogenic activity in vitro.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Antioxidant, Gallic Acid, Induces Apoptosis in HL-60RG Cells
Inoue M, et al.
Biochemical and Biophysical Research Communications, 204(2), 898-904 (1994)
Anti-Inflammatory Activity of Gallic Acid
Kroes B V, et al.
Planta Medica, 58(06), 499-504 (1992)
Gallic Acid Inhibits Histamine Release and Pro-inflammatory Cytokine Production in Mast Cells
Kim S H, et al.
Toxicological Sciences, 91(1), 123-131 (2005)
T R Aguiar et al.
Journal of dental research, 93(4), 417-422 (2014-02-28)
Although proanthocyanidins (PACs) modify dentin, the effectiveness of different PAC sources and the correlation with their specific chemical composition are still unknown. This study describes the chemical profiling of natural PAC-rich extracts from 7 plants using ultra high pressure/performance liquid
Plant polyphenols (vegetable tannins): gallic acid metabolism.
E Haslam et al.
Natural product reports, 11(1), 41-66 (1994-01-01)
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