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Merck
CN

V900370

Sigma-Aldrich

L-肌肽

98%, Vetec

别名:

β-丙氨酰-L-组氨酸

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关于此项目

经验公式(希尔记法):
C9H14N4O3
化学文摘社编号:
分子量:
226.23
Beilstein:
87671
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
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产品名称

L-肌肽, Vetec, reagent grade, 98%

等级

reagent grade

产品线

Vetec

方案

98%

表单

powder

颜色

white to off-white

mp

253 °C (dec.) (lit.)

储存温度

−20°C

SMILES字符串

NCCC(=O)N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1

InChI key

CQOVPNPJLQNMDC-ZETCQYMHSA-N

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Amino Acid Sequence

Ala-His

生化/生理作用

L-肌肽一种二肽,以毫摩尔浓度存在于脑、肌肉和眼睛晶状体中。 在模型系统中,它是一种有效的抗氧化剂,可清除氧自由基和过渡金属离子。 它可以阻断由次氯酸根阴离子以及乙醛、甲醛和丙二醛(脂质过氧化的主要产物)等有毒醛类诱导的蛋白质-蛋白质和蛋白质-DNA交联。 它还能抑制醛糖和酮糖还原糖诱导的非酶促蛋白糖化,并抑制毒性晚期糖基化终产物(AGE)的形成。这些活性使其被用于对衰老、动脉粥样硬化、阿尔茨海默病和糖尿病的继发性影响的研究。
具有强抗氧化性和抗糖化活性的二肽;阻断由反应性醛诱导的非酶促糖基化和蛋白质交联。

法律信息

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Johann Edge et al.
Experimental physiology, 98(2), 481-490 (2012-08-28)
It has been hypothesized that exercise-induced changes in metabolites and ions are crucial in the adaptation of contracting muscle. We tested this hypothesis by comparing adaptations to two different interval-training protocols (differing only in the rest duration between intervals), which
Ok-Nam Bae et al.
Stroke, 44(1), 205-212 (2012-12-20)
An urgent need exists to develop therapies for stroke that have high efficacy, long therapeutic time windows, and acceptable toxicity. We undertook preclinical investigations of a novel therapeutic approach involving supplementation with carnosine, an endogenous pleiotropic dipeptide. Efficacy and safety
Xue Ming et al.
Journal of proteome research, 11(12), 5856-5862 (2012-10-31)
Autism spectrum disorders (ASD) are a group of biological disorders with associated metabolic derangement. This study aimed to identify a pattern of metabolic perturbance in ASD using metabolomics in urinary specimens from 48 children with ASD and 53 age matched
Sanne Stegen et al.
PloS one, 10(3), e0121062-e0121062 (2015-03-25)
Muscle carnosine and its methylated form anserine are histidine-containing dipeptides. Both dipeptides have the ability to quench reactive carbonyl species and previous studies have shown that endogenous tissue levels are decreased in chronic diseases, such as diabetes. Rodent study: Skeletal
Alexander A Boldyrev et al.
Physiological reviews, 93(4), 1803-1845 (2013-10-19)
Carnosine (β-alanyl-l-histidine) was discovered in 1900 as an abundant non-protein nitrogen-containing compound of meat. The dipeptide is not only found in skeletal muscle, but also in other excitable tissues. Most animals, except humans, also possess a methylated variant of carnosine

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