搜索范围
03620
应用筛选条件
关键词:'03620'
显示 1-30 #N/A 4168 条结果 关于 "03620" 范围 论文
Daniela Michlmayr et al.
Journal of virology, 88(17), 9553-9567 (2014-06-06)
The encephalitic response to viral infection requires local chemokine production and the ensuing recruitment of immune and inflammatory leukocytes. Accordingly, chemokine receptors present themselves as plausible therapeutic targets for drugs aimed at limiting encephalitic responses. However, it remains unclear which
Tae Mi Yoon et al.
Oncology reports, 33(4), 1717-1722 (2015-02-25)
The transcription factor, early growth response 1 (EGR1) belongs to the early growth response family. EGR1 regulates the transactivation of genes involved in growth inhibition and apoptosis by ionizing radiation. The aims of the present study were to evaluate the expression
Jennifer R Fleming et al.
PLoS neglected tropical diseases, 8(6), e2936-e2936 (2014-06-13)
Animal African Trypanosomosis (AAT) presents a severe problem for agricultural development in sub-Saharan Africa. It is caused by several trypanosome species and current means of diagnosis are expensive and impractical for field use. Our aim was to discover antigens for
Hai-Yu Yang et al.
Drug and alcohol dependence, 139, 53-59 (2014-04-02)
It has been shown that opioid dependence-related neuronal plasticity may rely not only on protein synthesis, but also on protein degradation, mainly mediated by ubiquitin-proteasome system (UPS). The aim of the present study was to determine the effect of morphine
Adinda Diekstra et al.
Clinical chemistry, 61(1), 154-162 (2014-10-03)
Dideoxy-based chain termination sequencing developed by Sanger is the gold standard sequencing approach and allows clinical diagnostics of disorders with relatively low genetic heterogeneity. Recently, new next generation sequencing (NGS) technologies have found their way into diagnostic laboratories, enabling the
Viktória Szabolcsi et al.
Glia, 63(4), 567-594 (2014-11-26)
The calcium-binding protein parvalbumin (PV) hallmarks subpopulations of interneurons in the murine brain. We serendipitously observed the de novo expression of PV in ependymal cells of the lateral ventricle wall following in vivo lesioning and brain slicing for the preparation
Norbert Orgovan et al.
Advances in colloid and interface science, 211, 1-16 (2014-05-23)
This paper gives an overview of the advantages and associated caveats of the most common sample handling methods in surface-sensitive chemical and biological sensing. We summarize the basic theoretical and practical considerations one faces when designing and assembling the fluidic
Raúl Carrillo-Esper et al.
Cirugia y cirujanos, 72(4), 335-338 (2004-10-08)
The EDTA-dependent pseudothrombocytopenia is a false decrease in the number of platelets below the normal value when analyzed with automated devices. There is an incidence of 0.09 to 0.21% in hospitalized patients. Pseudothrombocytopenia is secondary to platelet clumping induced by
Yeonjoong Yong et al.
Fitoterapia, 98, 184-191 (2014-07-16)
Semaphorins are a class of membrane-bound and secreted proteins. They have been found to regulate basic cell functions such as axonal growth cone guidance and recent studies have focused on their effect on tumor progression. Semaphorin 3B (Sema3B) particularly is
Hae Mi Lee et al.
Cellular immunology, 290(1), 52-61 (2014-06-01)
The major factors and mechanisms by which natural killer (NK) cells are inhibited in cancer patients have not yet been well defined. In this study, we conducted a comparative analysis of the effects of TGF-β, IL-10, and IL-4 on primary
Elena Kurenova et al.
Cell cycle (Georgetown, Tex.), 13(16), 2542-2553 (2014-12-09)
Melanoma has the highest mortality rate of all skin cancers and a major cause of treatment failure is drug resistance. Tumors heterogeneity requires novel therapeutic strategies and new drugs targeting multiple pathways. One of the new approaches is targeting the
W A Gold et al.
Journal of molecular medicine (Berlin, Germany), 93(1), 63-72 (2014-09-12)
Rett syndrome (RTT) is a severe neurodevelopmental disorder, predominantly caused by loss of function mutations in the X-linked methyl-CpG-binding protein 2 (MECP2) gene. Despite the genetic cause being known in the majority of cases, the pathophysiology of the neurological phenotype
Chunzhao Zhao et al.
PLoS genetics, 10(5), e1004389-e1004389 (2014-05-17)
Mitogen-activated protein (MAP) kinase signaling cascades play important roles in the regulation of plant defense. The Raf-like MAP kinase kinase kinase (MAPKKK) EDR1 negatively regulates plant defense responses and cell death. However, how EDR1 functions, and whether it affects the
Amy H Buck et al.
Nature communications, 5, 5488-5488 (2014-11-26)
In mammalian systems RNA can move between cells via vesicles. Here we demonstrate that the gastrointestinal nematode Heligmosomoides polygyrus, which infects mice, secretes vesicles containing microRNAs (miRNAs) and Y RNAs as well as a nematode Argonaute protein. These vesicles are
Christoffer Martinussen et al.
American journal of physiology. Endocrinology and metabolism, 308(6), E535-E544 (2015-01-30)
Roux-en-Y gastric bypass surgery (RYGB) in patients with type 2 diabetes often leads to early disease remission, and it is unknown to what extent this involves improved pancreatic β-cell function per se and/or enhanced insulin- and non-insulin-mediated glucose disposal (glucose
Chikara Tanaka et al.
The Journal of cell biology, 207(1), 91-105 (2014-10-08)
In selective autophagy, degradation targets are specifically recognized, sequestered by the autophagosome, and transported into the lysosome or vacuole. Previous studies delineated the molecular basis by which the autophagy machinery recognizes those targets, but the regulation of this process is
Determinants of maternal pregnancy one-carbon metabolism and newborn human DNA methylation profiles.
Nina H van Mil et al.
Reproduction (Cambridge, England), 148(6), 581-592 (2014-11-14)
Maternal one-carbon (1-C) metabolism provides methylgroups for fetal development and programing by DNA methylation as one of the underlying epigenetic mechanisms. We aimed to investigate maternal 1-C biomarkers, folic acid supplement use, and MTHFR C677T genotype as determinants of 1-C
Abdulkader Albasri et al.
Anticancer research, 34(8), 3969-3974 (2014-07-31)
To determine whether phosphorylated focal adhesion kinase (P-FAK) has prognostic value in colorectal cancer (CRC) and to test whether it has any association with Tensin 4 (TNS4) expression. P-FAK expression was assessed using immunohistochemistry in 462 CRC cases arrayed on
Goran Mucic et al.
Behavioural brain research, 280, 45-50 (2014-12-03)
Although protein kinases and phosphatases have been reported to be involved in fear memory, information about these signalling molecules in the individual phases of contextual fear conditioning (cFC) is limited. C57BL/6J mice were tested in cFC, sacrificed and hippocampi were
Colin W Hay et al.
Psychoneuroendocrinology, 47, 43-55 (2014-07-09)
Expression or introduction of the neuropeptide substance-P (SP; encoded by the TAC1 gene in humans and Tac1 in rodents) in the amygdala induces anxiety related behaviour in rodents. In addition, pharmacological antagonism of the main receptor of SP in humans;
Lauriane Padet et al.
Immunobiology, 219(9), 687-694 (2014-05-31)
Allograft rejection and graft-versus-host disease (GvHD) are frequent complications following solid organ or stem cell transplantation in which T cell activation plays a central role. Despite the development of new immunosuppressive drugs that improve the success rate of transplantation, allograft
Ilona Joniec-Maciejak et al.
Pharmacological reports : PR, 66(4), 660-669 (2014-06-21)
The aim of this study was to examine the effect of AAV2-hIL-10 (vector containing cDNA for human interleukin 10) on dopaminergic system activity (measured as DA levels and TH mRNA expression in mouse striata), and other monoamine and amino acid
Sally Aldous et al.
International journal of cardiology, 177(1), 182-186 (2014-12-17)
The aim of this study is to compare a new improved point of care cardiac troponin assay (new POC-cTnI) with 1. its predecessor (old POC-cTnI) and 2. a high sensitivity assay (hs-cTnI) for the diagnosis of acute myocardial infarction (AMI)
Ali Karimi et al.
Gene, 554(2), 224-232 (2014-12-03)
Artemisia dracunculus L. (tarragon), a small shrubby perennial herb, is cultivated for the use of its aromatic leaves in seasoning, salads, etc., and in the preparation of tarragon vinegar. In the present work, genetic analysis of 29 cultivated individuals of
A Mignolet et al.
The Analyst, 140(7), 2393-2401 (2015-01-09)
FTIR spectroscopy was recently demonstrated to be a useful tool to obtain a unique fingerprint of the effects of several anticancer drugs on cells in culture. While FTIR spectroscopy appears to have a definite potential to sort anticancer drugs on
Renata Sokolik et al.
Human immunology, 75(12), 1188-1191 (2014-12-03)
Psoriatic arthritis (PsA) is a complex genetic disorder that results from an interplay between multiple genetic and environmental factors. The aim of the study was to assess the significance of the association between the HLA-C and HLA-E allelic groups and
A Ardeshirylajimi et al.
Cell proliferation, 48(1), 47-58 (2014-12-17)
To compare potential of four types of stem cell in tissue engineering and regenerative medicine applications, osteogenic capacity of newly introduced mesenchymal stem cells (MSCs) derived from buccal fat pads (BFP) (an adipose-encapsulated mass of the oral cavity), was compared
D-J Li et al.
Acta physiologica (Oxford, England), 213(3), 711-721 (2014-11-11)
Irisin, a novel myocyte-secreted hormone mediating beneficial effects of exercise on metabolism, is supposed to be an ideal therapeutic target for metabolic disorders such as obesity and diabetes. Here, we investigated the potential effects of metformin and glibenclamide, two antidiabetic
Jenny Xie et al.
The Journal of clinical investigation, 125(4), 1523-1532 (2015-03-10)
The Fanconi anemia/BRCA (FA/BRCA) pathway is a DNA repair pathway that is required for excision of DNA interstrand cross-links. The 17 known FA proteins, along with several FA-associated proteins (FAAPs), cooperate in this pathway to detect, unhook, and excise DNA
Gursimran Chandhok et al.
PloS one, 9(6), e98809-e98809 (2014-06-04)
Mutations in the copper (Cu) transporter gene ATP7B, the primary cause of Wilson disease (WD), result in high liver Cu and death of hepatocytes. Cu chelators and zinc salts are the two most important drugs used in the treatment of
1/139