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Amit Vaish et al.
Chemical communications (Cambridge, England), 49(26), 2685-2687 (2013-02-26)
We have developed a method based on self-assembly of thiols on Au substrates to immobilize membrane proteins at interfaces. Using water soluble nitrilotriacetic acid (NTA)-terminated oligo(ethylene glycol) thiols, a histidine-tagged G protein-coupled membrane receptor (GPCR) was captured in a defined
Laurens Pauwels et al.
Plant physiology, 169(2), 1405-1417 (2015-09-01)
Jasmonate (JA) signaling in plants is mediated by the JASMONATE ZIM-DOMAIN (JAZ) proteins that repress the activity of several transcription factors regulating JA-inducible gene expression. The hormone JA-isoleucine triggers the interaction of JAZ repressor proteins with the F-box protein CORONATINE
Federica Villa et al.
Current microbiology, 71(1), 106-114 (2015-05-11)
The effects of two commercially available immobilized enzymes (namely the glycosidase pectinase and the protease subtilisin A) at sub-lethal concentrations were investigated in terms of their influence on biofilm genesis, on the composition of the biofilm matrix, and their antibiotic
Mark R Battig et al.
Biomaterials, 35(27), 8040-8048 (2014-06-24)
While the discovery of highly potent biologics has led to the development of promising therapies for various human diseases, biologics can cause severe toxicity if delivered inappropriately. Thus, great efforts have been made to synthesize polymeric systems for safe and
Suk Ho Bhang et al.
Biomaterials, 55, 33-43 (2015-05-03)
At high concentrations, manganese (Mn) promotes cellular neurodevelopment but causes toxicity. Here, we report that Mn ion at high concentrations can be delivered to pheochromocytoma 12 (PC12) cells using gold nanoparticles (AuNPs) to enhance cellular neurodevelopment without toxicity. Mn(2+) release
Anais Berthelot-Ricou et al.
Fertility and sterility, 100(3), 882-888 (2013-06-13)
To assess the genotoxicity of three oocyte vitrification protocols. Murine assay. Biogenotoxicology research laboratory. CD1 female mice. Three mouse oocyte groups were exposed to three commercialized human oocyte vitrification protocols. Protocols 1 and 2 contained dimethyl sulfoxide and ethylene glycol
H Craig Heller et al.
Neurobiology of learning and memory, 116, 162-171 (2014-12-03)
Down syndrome (DS) has an incidence of about 1/700 births, and is therefore the most common cause of cognitive and behavioral impairments in children. Recent studies on mouse models of DS indicate that a number of pharmacotherapies could be beneficial
Huile Gao et al.
Molecular pharmaceutics, 11(8), 2755-2763 (2014-07-02)
Gliomas are hard to treat because of the two barriers involved: the blood-brain barrier and blood-tumor barrier. In this study, a dual-targeting ligand, angiopep-2, and an activatable cell-penetrating peptide (ACP) were functionalized onto nanoparticles for glioma-targeting delivery. The ACP was
Dmitry Shvartsman et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(7), 1243-1253 (2014-04-29)
Tissue reinnervation following trauma, disease, or transplantation often presents a significant challenge. Here, we show that the delivery of vascular endothelial growth factor (VEGF) from alginate hydrogels ameliorates loss of skeletal muscle innervation after ischemic injury by promoting both maintenance
Ajij Ahmed et al.
Journal of ethnopharmacology, 146(1), 411-416 (2013-01-22)
Adiantum capillus veneris Linn has been recommended in ancient literature of Unani system of medicine as an important ingredient of many formulations for the treatment of urolithiasis. Its decoction has long been used for the same purpose by several Unani
M Argun et al.
Eye (London, England), 28(6), 752-760 (2014-03-08)
Under conditions of oxidative stress, cell apoptosis is triggered through the mitochondrial intrinsic pathway. Increased levels of reactive oxygen species (ROS) are linked to excess cell loss and mediate the initiation of apoptosis in a diverse range of cell types.
Hongje Jang et al.
Advanced healthcare materials, 4(12), 1833-1840 (2015-06-19)
Herein, hybrid nanocomposite of praseodymium doped TiO2 nanocrystals and graphene oxide nanosheets are prepared by facile hydrothermal treatment. As-synthesized Pr-TiO2 /NGO hybrid nanocomposite exhibits enhanced photocatalytic activity under visible light irradiation by the intact graphene oxide and doped lanthanide mediated
Sven Amrhein et al.
Biotechnology and bioengineering, 112(12), 2485-2494 (2015-06-16)
The surface hydrophobicity of a protein is an important factor for its interactions in solution and thus the outcome of its production process. Yet most of the methods are not able to evaluate the influence of these hydrophobic interactions under
Silke Klocke et al.
Reproductive biomedicine online, 29(2), 251-258 (2014-06-24)
This study investigated the effects of supra-zero storage on ovarian cortex of 12 premenopausal patients before cryopreservation. Fresh ovarian tissue (control) was either vitrified immediately or stored at 4°C for 24 h or 48 h before vitrification. This study assessed
Maria Desemparats Saenz-de-Juano et al.
PloS one, 10(4), e0125157-e0125157 (2015-04-29)
Very limited information on the post-implantatory effects of vitrification has been published till now. We observed in a previous study that the vitrification procedure for the cryopreservation of embryos introduced transcriptomic and proteomic modifications in the rabbit foetal placenta at
Diana Adliene et al.
Radiation protection dosimetry, 165(1-4), 406-409 (2015-03-31)
Evaluation of the new lead-free optically transparent nanocomposites is provided in this paper along with the introduction to their fabrication technologies and the results of investigation of their X-ray attenuating and optical properties before and after their exposure to high
Lei Han et al.
ACS applied materials & interfaces, 7(26), 14463-14470 (2015-06-16)
As substitutes for natural peroxidases, most nanomaterial-based enzyme mimetics (nanozymes) have unique properties such as high stability, low-cost, large surface area, and high catalytic activity. However, they usually work in acidic conditions and thus impede their real applications. In this
Lili Huang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(49), 16309-16319 (2014-12-05)
The hypothalamic NPY system plays an important role in regulating food intake and energy expenditure. Different biological actions of NPY are assigned to NPY receptor subtypes. Recent studies demonstrated a close relationship between food intake and growth hormone (GH) secretion;
Zhijun Tai et al.
ChemSusChem, 6(4), 652-658 (2013-03-06)
Following our previous report on the selective transformation of cellulose to ethylene glycol (EG) over a binary catalyst composed of tungstic acid and Ru/C, we herein report a new low-cost but more effective binary catalyst by using Raney nickel in
James A Kruse
Critical care clinics, 28(4), 661-711 (2012-09-25)
Accidental or intentional ingestion of substances containing methanol and ethylene glycol can result in death, and some survivors are left with blindness, renal dysfunction, and chronic brain injury. However, even in large ingestions, a favorable outcome is possible if the
Tomoki Nishikawa et al.
Organic & biomolecular chemistry, 13(47), 11426-11431 (2015-10-08)
Among l- and d-oligopeptides with multiple pyrenes as pendants, the dipeptides with two and three pyrenes showed blue-coloured circularly polarised luminescence as high as |gem|≈ (0.86-1.1) × 10(-2) at around 450 nm, reflecting from exciton couplets of twisted pyrenes.
Sandra Flessau et al.
Physical chemistry chemical physics : PCCP, 16(22), 10444-10455 (2014-05-03)
The optical properties of single colloidal semiconductor nanoparticles (NPs) are considerably influenced by the direct environment of the NPs. Here, the influence of different liquid and solid glycol matrices on CdSe-based NPs is investigated. Since the fluorescence of individual NPs
Ying-Ping Deng et al.
Experimental neurology, 269, 213-223 (2015-04-12)
Hypomyelination is the major cause of neurodevelopmental deficits that are associated with perinatal white matter injury. Chondroitin sulfate proteoglycans (CSPGs) are known to exert inhibitory effects on the migration and differentiation of oligodendrocytes (OLs). However, few studies describe the roles
Hua Wang et al.
PloS one, 9(6), e97996-e97996 (2014-06-06)
In the biosynthesis of polyketides, ketoreductases (KRs) are an important group of enzymes that determine the chiralities of the carbon backbones. SiaM is a special member of this group that can recognize substrates with different lengths and can be used
Panfeng Yu et al.
Journal of chromatography. A, 1348, 27-33 (2014-05-20)
In this paper, polyethylene glycol modified (PEGylated) magnetic carbon nanotubes were developed as solid-phase extraction nanosorbents for the determination of methylprednisolone in rat plasma. The procedure mainly involved two steps including preparation of PEGylated magnetic nanosorbents and bioanalysis. Monodisperse magnetites
Taomin Huang et al.
Talanta, 147, 501-509 (2015-11-26)
To the best of our knowledge, this study is the first to successfully apply a novel, highly selective enrichment technique based on boronic acid-functionalized core-shell magnetic microspheres (BA-Fe3O4@SiO2-Au@mSiO2) with a large surface area and uniform pore size, to determine the
Raquel García-González et al.
Talanta, 142, 11-19 (2015-05-25)
Amplification-free (referring to enzymatic amplification step) detection methodologies are increasing in biosensor development due to the need of faster and simpler protocols. However, for maintaining sensitivity without this step, highly detectable molecules or very sensitive detection techniques are required. The
Lara Mouttham et al.
Journal of assisted reproduction and genetics, 32(8), 1239-1250 (2015-08-08)
The objective of this study is to characterize the impact of exposure to cryoprotectants followed by vitrification on primordial follicle survival and activation using a fetal bovine model. In the first study, fetal bovine cortical pieces were exposed to cryoprotectants
Hyunryung Kim et al.
Materials science & engineering. C, Materials for biological applications, 40, 324-335 (2014-05-27)
Electrospun silk fibroin (SF) scaffolds provide large surface area, high porosity, and interconnection for cell adhesion and proliferation and they may replace collagen for many tissue engineering applications. Despite such advantages, electrospun SF scaffolds are still limited as bone tissue
Frank F J Simonis et al.
Magnetic resonance in medicine, 73(3), 1184-1189 (2014-03-26)
MR thermometry (MRT) is a noninvasive method for measuring temperature that can potentially be used for radio frequency (RF) safety monitoring. This application requires measuring absolute temperature. In this study, a multigradient-echo (mGE) MRT sequence was used for that purpose.
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