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Amit Vaish et al.
Chemical communications (Cambridge, England), 49(26), 2685-2687 (2013-02-26)
We have developed a method based on self-assembly of thiols on Au substrates to immobilize membrane proteins at interfaces. Using water soluble nitrilotriacetic acid (NTA)-terminated oligo(ethylene glycol) thiols, a histidine-tagged G protein-coupled membrane receptor (GPCR) was captured in a defined
Diana Adliene et al.
Radiation protection dosimetry, 165(1-4), 406-409 (2015-03-31)
Evaluation of the new lead-free optically transparent nanocomposites is provided in this paper along with the introduction to their fabrication technologies and the results of investigation of their X-ray attenuating and optical properties before and after their exposure to high
Lei Han et al.
ACS applied materials & interfaces, 7(26), 14463-14470 (2015-06-16)
As substitutes for natural peroxidases, most nanomaterial-based enzyme mimetics (nanozymes) have unique properties such as high stability, low-cost, large surface area, and high catalytic activity. However, they usually work in acidic conditions and thus impede their real applications. In this
Suk Ho Bhang et al.
Biomaterials, 55, 33-43 (2015-05-03)
At high concentrations, manganese (Mn) promotes cellular neurodevelopment but causes toxicity. Here, we report that Mn ion at high concentrations can be delivered to pheochromocytoma 12 (PC12) cells using gold nanoparticles (AuNPs) to enhance cellular neurodevelopment without toxicity. Mn(2+) release
Lili Huang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(49), 16309-16319 (2014-12-05)
The hypothalamic NPY system plays an important role in regulating food intake and energy expenditure. Different biological actions of NPY are assigned to NPY receptor subtypes. Recent studies demonstrated a close relationship between food intake and growth hormone (GH) secretion;
Anais Berthelot-Ricou et al.
Fertility and sterility, 100(3), 882-888 (2013-06-13)
To assess the genotoxicity of three oocyte vitrification protocols. Murine assay. Biogenotoxicology research laboratory. CD1 female mice. Three mouse oocyte groups were exposed to three commercialized human oocyte vitrification protocols. Protocols 1 and 2 contained dimethyl sulfoxide and ethylene glycol
Laurens Pauwels et al.
Plant physiology, 169(2), 1405-1417 (2015-09-01)
Jasmonate (JA) signaling in plants is mediated by the JASMONATE ZIM-DOMAIN (JAZ) proteins that repress the activity of several transcription factors regulating JA-inducible gene expression. The hormone JA-isoleucine triggers the interaction of JAZ repressor proteins with the F-box protein CORONATINE
Ajij Ahmed et al.
Journal of ethnopharmacology, 146(1), 411-416 (2013-01-22)
Adiantum capillus veneris Linn has been recommended in ancient literature of Unani system of medicine as an important ingredient of many formulations for the treatment of urolithiasis. Its decoction has long been used for the same purpose by several Unani
H Craig Heller et al.
Neurobiology of learning and memory, 116, 162-171 (2014-12-03)
Down syndrome (DS) has an incidence of about 1/700 births, and is therefore the most common cause of cognitive and behavioral impairments in children. Recent studies on mouse models of DS indicate that a number of pharmacotherapies could be beneficial
Huile Gao et al.
Molecular pharmaceutics, 11(8), 2755-2763 (2014-07-02)
Gliomas are hard to treat because of the two barriers involved: the blood-brain barrier and blood-tumor barrier. In this study, a dual-targeting ligand, angiopep-2, and an activatable cell-penetrating peptide (ACP) were functionalized onto nanoparticles for glioma-targeting delivery. The ACP was
Federica Villa et al.
Current microbiology, 71(1), 106-114 (2015-05-11)
The effects of two commercially available immobilized enzymes (namely the glycosidase pectinase and the protease subtilisin A) at sub-lethal concentrations were investigated in terms of their influence on biofilm genesis, on the composition of the biofilm matrix, and their antibiotic
Mark R Battig et al.
Biomaterials, 35(27), 8040-8048 (2014-06-24)
While the discovery of highly potent biologics has led to the development of promising therapies for various human diseases, biologics can cause severe toxicity if delivered inappropriately. Thus, great efforts have been made to synthesize polymeric systems for safe and
Dmitry Shvartsman et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(7), 1243-1253 (2014-04-29)
Tissue reinnervation following trauma, disease, or transplantation often presents a significant challenge. Here, we show that the delivery of vascular endothelial growth factor (VEGF) from alginate hydrogels ameliorates loss of skeletal muscle innervation after ischemic injury by promoting both maintenance
Ying-Ping Deng et al.
Experimental neurology, 269, 213-223 (2015-04-12)
Hypomyelination is the major cause of neurodevelopmental deficits that are associated with perinatal white matter injury. Chondroitin sulfate proteoglycans (CSPGs) are known to exert inhibitory effects on the migration and differentiation of oligodendrocytes (OLs). However, few studies describe the roles
Zhijun Tai et al.
ChemSusChem, 6(4), 652-658 (2013-03-06)
Following our previous report on the selective transformation of cellulose to ethylene glycol (EG) over a binary catalyst composed of tungstic acid and Ru/C, we herein report a new low-cost but more effective binary catalyst by using Raney nickel in
James A Kruse
Critical care clinics, 28(4), 661-711 (2012-09-25)
Accidental or intentional ingestion of substances containing methanol and ethylene glycol can result in death, and some survivors are left with blindness, renal dysfunction, and chronic brain injury. However, even in large ingestions, a favorable outcome is possible if the
Hongje Jang et al.
Advanced healthcare materials, 4(12), 1833-1840 (2015-06-19)
Herein, hybrid nanocomposite of praseodymium doped TiO2 nanocrystals and graphene oxide nanosheets are prepared by facile hydrothermal treatment. As-synthesized Pr-TiO2 /NGO hybrid nanocomposite exhibits enhanced photocatalytic activity under visible light irradiation by the intact graphene oxide and doped lanthanide mediated
Sven Amrhein et al.
Biotechnology and bioengineering, 112(12), 2485-2494 (2015-06-16)
The surface hydrophobicity of a protein is an important factor for its interactions in solution and thus the outcome of its production process. Yet most of the methods are not able to evaluate the influence of these hydrophobic interactions under
Silke Klocke et al.
Reproductive biomedicine online, 29(2), 251-258 (2014-06-24)
This study investigated the effects of supra-zero storage on ovarian cortex of 12 premenopausal patients before cryopreservation. Fresh ovarian tissue (control) was either vitrified immediately or stored at 4°C for 24 h or 48 h before vitrification. This study assessed
Maria Desemparats Saenz-de-Juano et al.
PloS one, 10(4), e0125157-e0125157 (2015-04-29)
Very limited information on the post-implantatory effects of vitrification has been published till now. We observed in a previous study that the vitrification procedure for the cryopreservation of embryos introduced transcriptomic and proteomic modifications in the rabbit foetal placenta at
Guang Yang et al.
ACS nano, 9(2), 1161-1174 (2015-01-21)
Nanocarriers have attracted broad attention in cancer therapy because of their ability to carry drugs preferentially into cancer tissue, but their application is still limited due to the systemic toxicity and low delivery efficacy of intravenously delivered chemotherapeutics. In this
Jaspreet Singh Kochhar et al.
Pharmaceutical research, 31(7), 1724-1734 (2014-01-23)
To fabricate microneedle arrays directly off a photomask using a simple photolithographical approach and evaluate their potential for delivering collagen. A simple photolithographical approach was developed by using photomask consisting of embedded micro-lenses that govern microneedle geometry in a mould
Chun-ling Dai et al.
Journal of neural transmission (Vienna, Austria : 1996), 122(4), 607-617 (2014-09-23)
Intraneuronal accumulation of abnormally hyperphosphorylated tau in the brain is a histopathological hallmark of Alzheimer's disease and a family of related neurodegenerative disorders collectively called tauopathies. At present there is no effective treatment available for these progressive neurodegenerative diseases which
J P Li et al.
Journal of biochemical and biophysical methods, 22(4), 311-320 (1991-05-01)
An affinity chromatography column packed with nonporous agarose beads derivatized with human growth hormone via carbonyldiimidazol was used for the purification of antibodies against human growth hormone from antiserum. Desorption with 1 M sodium chloride in 60% ethylene glycol at
Rifat J Hussain et al.
Physiology & behavior, 138, 113-117 (2014-12-03)
Our laboratory has previously shown that antidepressants regulate glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC). To determine if PFC GR are involved in antidepressant effects on behavior or hypothalamic-pituitary-adrenocortical (HPA) axis activity, we treated floxed GR male mice
Xuan Zhong Li et al.
Journal of microbiology and biotechnology, 23(2), 195-204 (2013-02-16)
While structured packing modules are known to be efficient for surface wetting and gas-liquid exchange in abiotic surface catalysis, this model study explores structured packing as a growth surface for catalytic biofilms. Microbial biofilms have been proposed as self-immobilized and
Mohamed R Berber et al.
Scientific reports, 5, 16711-16711 (2015-11-26)
Driven by the demand for the commercialization of fuel cell (FC) technology, we describe the design and fabrication of a highly durable FC electrocatalyst based on double-polymer-coated carbon nanotubes for use in polymer electrolyte membrane fuel cells. The fabricated electrocatalyst
Nandi J Reddy et al.
Clinical toxicology (Philadelphia, Pa.), 48(10), 967-973 (2011-01-05)
Ethylene glycol, diethylene glycol and methanol are widely available chemicals and are found in a variety of common household products including antifreeze, windshield washer fluid, brake fluid and lubricants. Following ingestion of these glycols and methanol, patients frequently develop an
Qiang Shi et al.
Colloids and surfaces. B, Biointerfaces, 125, 28-33 (2014-12-02)
There is an urgent need to develop blood-contacting biomaterials with long-term anti-hemolytic capability. To obtain such biomaterials, we coaxially electrospin [ascorbic acid (AA) and lecithin]/poly (ethylene oxide) (PEO) core-shell nanofibers onto the surface of styrene-b-(ethylene-co-butylene)-b-styrene elastomer (SEBS) that has been
Baozhang Li et al.
Sensors (Basel, Switzerland), 14(6), 9889-9899 (2014-06-06)
We have developed a highly sensitive flexible pressure sensor based on a piezopolymer and silver nanowires (AgNWs) composite. The composite nanofiber webs are made by electrospinning mixed solutions of poly(inylidene fluoride) (PVDF) and Ag NWs in a cosolvent mixture of
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