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Jessica N Cooke Bailey et al.
Human genetics, 133(10), 1319-1330 (2014-07-20)
Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. Using genome-wide association single-nucleotide polymorphism data from the Glaucoma Genes and Environment study and National Eye Institute Glaucoma Human Genetics Collaboration comprising 3,108 cases and 3,430 controls, we assessed
Lucas Frungillo et al.
Nature communications, 5, 5401-5401 (2014-11-12)
Nitrogen assimilation plays a vital role in plant metabolism. Assimilation of nitrate, the primary source of nitrogen in soil, is linked to the generation of the redox signal nitric oxide (NO). An important mechanism by which NO regulates plant development
T Karayannis et al.
Nature, 511(7508), 236-240 (2014-05-30)
Although considerable evidence suggests that the chemical synapse is a lynchpin underlying affective disorders, how molecular insults differentially affect specific synaptic connections remains poorly understood. For instance, Neurexin 1a and 2 (NRXN1 and NRXN2) and CNTNAP2 (also known as CASPR2)
Maram Hilwi et al.
The Journal of biological chemistry, 289(49), 34258-34266 (2014-10-24)
The sodium- and chloride-coupled GABA transporter GAT-1 is a member of the neurotransmitter:sodium:symporters, which are crucial for synaptic transmission. Structural work on the bacterial homologue LeuT suggests that extracellular loop 4 closes the extracellular solvent pathway when the transporter becomes
Na-Hyun Kim et al.
Biochemical and biophysical research communications, 447(1), 205-209 (2014-04-08)
Major pelvic ganglia (MPG) are relay centers for autonomic reflexes such as micturition and penile erection. MPG innervate the urogenital system, including bladder. γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system, and may also
Richard A DeFazio et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(49), 16296-16308 (2014-12-05)
Gonadotropin-releasing hormone (GnRH) secretion is regulated by estradiol feedback. This feedback switches from negative to positive in females; this switch depends on time of day in many species. Estradiol feedback is likely conveyed via afferents. Kisspeptin neurons of the arcuate
Clinical practice. Postherpetic neuralgia.
Robert W Johnson et al.
The New England journal of medicine, 371(16), 1526-1533 (2014-10-16)
Stephanie C Tjen-A-Looi et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(11), R1313-R1323 (2014-09-19)
Phenylbiguanide (PBG) stimulates cardiopulmonary receptors and cardiovascular reflex responses, including decreases in blood pressure and heart rate mediated by the brain stem parasympathetic cardiac neurons in the nucleus ambiguus and nucleus tractus solitarius (NTS). Electroacupuncture (EA) at P5-6 stimulates sensory
Shang-Feng Gao et al.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 17(1), 124-144 (2010-03-20)
Stress response and depression have a significant impact on modern society. Although the symptoms are well characterized, the molecular mechanisms underlying depression are largely unknown. The monoamine hypothesis, which postulates dysfunctional noradrenergic and serotonergic systems as the underlying primary cause
Pregabalin for the treatment of painful hand-foot skin reaction associated with dabrafenib.
Evelyn Lilly et al.
JAMA dermatology, 151(1), 102-103 (2014-09-25)
Pregabalin versus pramipexole for restless legs syndrome.
Ion Anghelescu et al.
The New England journal of medicine, 370(21), 2049-2050 (2014-05-23)
Jeffrey T Guptill et al.
Muscle & nerve, 50(1), 47-51 (2014-03-19)
We determined health plan paid costs and healthcare resource usage of patients with chronic inflammatory demyelinating polyneuropathy (CIDP). CIDP patients from 9 U.S. commercial health plans with claims in 2011 were identified from the Accordant Health Services claims database. We
Hussein A N Al-Wadei et al.
Molecular nutrition & food research, 55(12), 1745-1758 (2011-08-02)
GABA is a bioactive constituent of fruits, vegetables, cereals and is believed to play a role in defense against stress in plants. In animals, it acts as an inhibitory neurotransmitter in brain while also expressed in non-neuronal cells. Studies have
Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research.
Anna Naito et al.
Molecular pharmacology, 86(6), 635-646 (2014-09-24)
A critical obstacle to developing effective medications to prevent and/or treat alcohol use disorders is the lack of specific knowledge regarding the plethora of molecular targets and mechanisms underlying alcohol (ethanol) action in the brain. To identify the role of
Arnulf H Koeppen et al.
Journal of neuropathology and experimental neurology, 74(2), 166-176 (2015-01-13)
Atrophy of large neurons in the dentate nucleus (DN) is an important pathologic correlate of neurologic disability in patients with Friedreich ataxia (FA). Thinning of the DN was quantified in 29 autopsy cases of FA and 2 carriers by measuring
Mayrut Urióstegui-Acosta et al.
Toxicology and applied pharmacology, 279(3), 391-400 (2014-07-08)
Methamidophos (MET) is a highly toxic organophosphate (OP) pesticide that is widely used in developing countries. MET has male reproductive effects, including decreased fertility. We evaluated MET effects on sperm quality, fertilization and DNA integrity, exploring the sensitivity of different
Rossana Coda et al.
International journal of food microbiology, 193, 34-42 (2014-12-03)
The effects of air classification and lactic acid bacteria fermentation on the reduction of anti-nutritional factors (vicine and convicine, trypsin inhibitor activity, condensed tannins and phytic acid) and in vitro protein and starch digestibility of faba bean flour were studied.
Elke Hattingen et al.
Epilepsia, 55(7), 1030-1037 (2014-06-07)
Juvenile myoclonic epilepsy (JME) has been considered to be a frontal variant of thalamocortical network dysfunction in epilepsy. Changes of γ-aminobutyric acid (GABA)ergic neurotransmission may play a key role in this dysfunction. Magnetic resonance spectroscopy (MRS) is the only noninvasive
Abdolreza Najafi Anaraki et al.
Archives of gynecology and obstetrics, 290(1), 47-52 (2014-02-13)
Pain after cesarean delivery is a leading cause of chronic pain and there are many attempts to reduce it without total success. Gabapentin is effective in reducing acute and chronic pain with little experience in parturient. The purpose of this
Jesse Jackson et al.
Nature neuroscience, 17(10), 1362-1370 (2014-09-01)
Activity flow through the hippocampus is thought to arise exclusively from unidirectional excitatory synaptic signaling from CA3 to CA1 to the subiculum. Theta rhythms are important for hippocampal synchronization during episodic memory processing; thus, it is assumed that theta rhythms
Kunihiko Obata
Proceedings of the Japan Academy. Series B, Physical and biological sciences, 89(4), 139-156 (2013-04-12)
Signal transmission through synapses connecting two neurons is mediated by release of neurotransmitter from the presynaptic axon terminals and activation of its receptor at the postsynaptic neurons. γ-Aminobutyric acid (GABA), non-protein amino acid formed by decarboxylation of glutamic acid, is
Haixing Li et al.
Amino acids, 39(5), 1107-1116 (2010-04-07)
Gamma-aminobutyric acid is a non-protein amino acid that is widely present in organisms. Several important physiological functions of gamma-aminobutyric acid have been characterized, such as neurotransmission, induction of hypotension, diuretic effects, and tranquilizer effects. Many microorganisms can produce gamma-aminobutyric acid
Stephanie C Licata et al.
Psychiatry research, 224(1), 28-33 (2014-08-02)
Individuals with major depressive disorder (MDD) often use hypnotics like zolpidem (Ambien(®)) to improve sleep in addition to their selective serotonin reuptake inhibitor (SSRI) regimen. SSRIs act in part to restore disrupted GABAergic activity, but benzodiazepines and related drugs have
Jaisan Islam et al.
International journal of molecular sciences, 22(16) (2021-08-28)
The nucleus accumbens core (NAcc) is an important component of brain reward circuitry, but studies have revealed its involvement in pain circuitry also. However, its effect on trigeminal neuralgia (TN) and the mechanism underlying it are yet to be fully
Melissa A Farmer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(17), 5747-5753 (2014-04-25)
Chronic pain is often associated with sexual dysfunction, suggesting that pain can reduce libido. We find that inflammatory pain reduces sexual motivation, measured via mounting behavior and/or proximity in a paced mating paradigm, in female but not male laboratory mice.
Patrice K Nicholas et al.
The Journal of the Association of Nurses in AIDS Care : JANAC, 25(4), 318-329 (2014-04-05)
Peripheral neuropathy is a common and vexing symptom for people living with HIV infection (PLWH). Neuropathy occurs in several different syndromes and is identified in the literature as distal sensory polyneuropathy or distal sensory peripheral neuropathy. More recently, the HIV
Sahar Farajnia et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(26), 9627-9632 (2014-07-01)
The balance between excitation and inhibition is essential for the proper function of neuronal networks in the brain. The inhibitory neurotransmitter γ-aminobutyric acid (GABA) contributes to the network dynamics within the suprachiasmatic nucleus (SCN), which is involved in seasonal encoding.
Barna Dudok et al.
Nature neuroscience, 18(1), 75-86 (2014-12-09)
A major challenge in neuroscience is to determine the nanoscale position and quantity of signaling molecules in a cell type- and subcellular compartment-specific manner. We developed a new approach to this problem by combining cell-specific physiological and anatomical characterization with
B M Mishriky et al.
British journal of anaesthesia, 114(1), 10-31 (2014-09-12)
We performed this systematic review to assess the analgesic efficacy of perioperative pregabalin. Subgroup analyses and meta-regression were performed to assess the impact of individual dose and frequency of pregabalin administration on analgesic efficacy. We included 55 studies. When all
Emerging perspectives in perioperative use of gabapentinoids.
Veena Kachhwah et al.
Anesthesiology, 121(2), 424-424 (2014-07-23)
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