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Rebeca Alvariño et al.
ACS chemical neuroscience, 13(16), 2449-2463 (2022-07-29)
Neuroprotective properties of five previously described furanoditerpenes 1-5, isolated from Spongia (Spongia) tubulifera, were evaluated in an in vitro oxidative stress model in SH-SY5Y cells. Dose-response treatments revealed that 1-5 improved cell survival at nanomolar concentrations through the restoration of
Tzyy-Yue Wong et al.
Journal of clinical medicine, 7(11) (2018-11-08)
The dynamics of a living body enables organs to experience mechanical stimulation at cellular level. The human cardiomyocytes cell line provides a source for simulating heart dynamics; however, a limited understanding of the mechanical stimulation effect on them has restricted
Pei-Wen Cheng et al.
Diabetes, 64(10), 3413-3424 (2015-04-18)
Aberrant Wnt signaling appears to play an important role in the onset of diabetes. Moreover, the insulin signaling pathway is defective in the nucleus tractus solitarii (NTS) of spontaneously hypertensive rats (SHRs) and fructose-fed rats. Nevertheless, the relationships between Wnt
María Villafranca-Faus et al.
Nature communications, 12(1), 5286-5286 (2021-09-08)
Vomeronasal information is critical in mice for territorial behavior. Consequently, learning the territorial spatial structure should incorporate the vomeronasal signals indicating individual identity into the hippocampal cognitive map. In this work we show in mice that navigating a virtual environment
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation.
Pruitt, K; Zinn, RL; Ohm, JE; McGarvey, KM; Kang, SH; Watkins, DN; Herman, JG; Baylin, SB
PLoS Genetics null
Pei-Wen Cheng et al.
Biomedicines, 9(11) (2021-11-28)
Traumatic brain injury confers a significant and growing public health burden. It is a major environmental risk factor for dementia. Nonetheless, the mechanism by which primary mechanical injury leads to neurodegeneration and an increased risk of dementia-related diseases is unclear.
Yu-Te Lin et al.
Journal of clinical medicine, 7(10) (2018-10-12)
Recent studies have indicated that several anti-hypertensive drugs may delay the development and progression of Alzheimer's disease (AD). However, the relationships among AD, hypertension, and oxidative stress remain to be elucidated. Here, we aimed to determine whether reactive oxygen species
Chien-Yu Kao et al.
Journal of neurochemistry, 126(1), 4-18 (2013-05-08)
Valproic acid (VPA) is the primary mood-stabilizing drug to exert neuroprotective effects and to treat bipolar disorder in clinic. Fibroblast growth factor 1 (FGF1) has been shown to regulate cell proliferation, cell division, and neurogenesis. Human FGF1 gene 1B promoter
Hui Sheng et al.
International journal of medical sciences, 10(6), 782-789 (2013-05-01)
We previously reported that the constitutional flavonoid glycosides derived from herb Epimedium (EF, composed of seven flavonoid compounds with common nuclear stem) exerted beneficial effects on the bone, including promoting bone formation and inhibiting bone marrow fat deposition. Recent in
Chong-Kuei Lii et al.
Oncotarget, 7(18), 25162-25179 (2016-04-02)
Fascin-1, an actin-bundling protein, plays an important role in cancer cell migration and invasion; however, the underlying mechanism remains unclear. On the basis of a 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced cell migration model, it was shown that TPA increased fascin-1 mRNA and
Inhibition of cyclin-dependent kinase 5 but not of glycogen synthase kinase 3-? prevents neurite retraction and tau hyperphosphorylation caused by secretable products of human T-cell leukemia virus type I-infected lymphocytes.
Maldonado, H; Ramirez, E; Utreras, E; Pando, ME; Kettlun, AM; Chiong, M; Kulkarni et al.
Journal of Neuroscience Research null
Laia Lidón et al.
International journal of molecular sciences, 22(10) (2021-06-03)
Tau protein is largely responsible for tauopathies, including Alzheimer's disease (AD), where it accumulates in the brain as insoluble aggregates. Tau mRNA is regulated by alternative splicing, and inclusion or exclusion of exon 10 gives rise to the 3R and
Sevgican Demir et al.
Science advances, 8(42), eabo5555-eabo5555 (2022-10-22)
Maladaptive insulin signaling is a key feature in the pathogenesis of severe metabolic disorders, including obesity and diabetes. Enhancing insulin sensitivity represents a major goal in the treatment of patients affected by diabetes. Here, we identify transforming growth factor-β1 stimulated
Ahmed M Maged et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(12), 1627-1631 (2015-06-06)
To compare the new delayed start protocol against the conventional gonadotropin (Gn)-releasing hormone antagonist protocol in poor responders (PORs). A total of 160 women with poor response to previous in vitro fertilization (IVF) cycle were randomized either to start Gn
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