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Wenyi Yang et al.
Frontiers in immunology, 13, 728455-728455 (2022-07-01)
Sphingosine-1-phosphate lyase is encoded by the Sgpl1 gene, degrades S1P, and is crucial for S1P homeostasis in animal models and humans. S1P lyase deficient patients suffer from adrenal insufficiency, severe lymphopenia, and skin disorders. In this study, we used random
Herlon Victor Rodrigues Silva et al.
Biopreservation and biobanking, 18(5), 415-424 (2020-08-12)
Anhydrous preservation is a promising approach for storage of living biomaterials at nonfreezing temperatures. Using the domestic cat model, the objectives of this study were to characterize changes in histology, DNA integrity, and viability of testicular tissues from adult versus
Noémie Hamilton et al.
Glia, 68(7), 1531-1545 (2020-03-27)
The contribution of microglia in neurological disorders is emerging as a leading disease driver rather than a consequence of pathology. RNAseT2-deficient leukoencephalopathy is a severe childhood white matter disorder affecting patients in their first year of life and mimicking a
Monitoring basal autophagy in the retina utilizing CAG-mRFP-EGFP-MAP1LC3B reporter mouse: technical and biological considerations.
Ramachandra Rao, et al.
Autophagy, 18, 1187-1201 (2022)
Jorge Santini-González et al.
Biomaterials, 273, 120808-120808 (2021-04-26)
The peri-islet extracellular matrix (ECM) is a key component of the microenvironmental niche surrounding pancreatic islets of Langerhans. The cell anchorage and signaling provided by the peri-islet ECM is critical for optimum beta cell glucose responsiveness, but islets lose this
Risheng Ye et al.
eLife, 3, doi:10-doi:10 (2014-10-24)
As an adipokine in circulation, adiponectin has been extensively studied for its beneficial metabolic effects. While many important functions have been attributed to adiponectin under high-fat diet conditions, little is known about its essential role under regular chow. Employing a
Joshua M Weiss et al.
Nature, 604(7905), 354-361 (2022-04-01)
Oncogenic alterations to DNA are not transforming in all cellular contexts1,2. This may be due to pre-existing transcriptional programmes in the cell of origin. Here we define anatomic position as a major determinant of why cells respond to specific oncogenes.
Wancheng Liu et al.
Cellular & molecular immunology, 18(12), 2660-2672 (2021-11-17)
The tumor microenvironment (TME), including infiltrated immune cells, is known to play an important role in tumor growth; however, the mechanisms underlying tumor immunogenicity have not been fully elucidated. Here, we discovered an unexpected role for the transcription factor SIX1
Tiantian Xiong et al.
Cancer science, 113(6), 1955-1967 (2022-04-02)
Neutrophils are the first defenders of the innate system for injury and infection. They have gradually been recognized as important participants in tumor initiation and development due to their heterogeneity and plasticity. In the tumor microenvironment (TME), neutrophils can exert
Matheus H W Crommentuijn et al.
Journal for immunotherapy of cancer, 8(1) (2020-04-19)
Glioblastoma (GBM) is the most common and deadliest form of brain cancer in adults. Standard treatment, consisting of surgery and radiochemotherapy, only provides a modest survival benefit and is incapable of combating infiltrating GBM cells in other parts of the
Synergistic effect of CD47 blockade in combination with cordycepin treatment against cancer.
Feng, et al.
Frontiers in Pharmacology, 14, 1144330-1144330 (2023)
An engineered antibody binds a distinct epitope and is a potent inhibitor of murine and human VISTA.
Nishant Mehta et al.
Scientific reports, 10(1), 15171-15171 (2020-09-18)
V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA) is an immune checkpoint that maintains peripheral T cell quiescence and inhibits anti-tumor immune responses. VISTA functions by dampening the interaction between myeloid cells and T cells, orthogonal to PD-1 and
Uta Gehlsen et al.
International journal of molecular sciences, 22(12) (2021-07-03)
Ocular graft-versus-host disease (oGVHD) is a fast progressing, autoimmunological disease following hematopoietic stem cell transplantation, leading to severe inflammation of the eye and destruction of the lacrimal functional unit with consecutive sight-threatening consequences. The therapeutic "window of opportunity" is narrow
Martyna Okuniewska et al.
Cell reports, 36(2), 109368-109368 (2021-07-15)
T cell expression of sphingosine 1-phosphate (S1P) receptor 1 (S1PR1) enables T cell exit from lymph nodes (LNs) into lymph, while endothelial S1PR1 expression regulates vascular permeability. Drugs targeting S1PR1 treat autoimmune disease by trapping pathogenic T cells within LNs, but they
Djalma S Lima-Junior et al.
Cell, 184(14), 3794-3811 (2021-06-25)
The microbiota plays a fundamental role in regulating host immunity. However, the processes involved in the initiation and regulation of immunity to the microbiota remain largely unknown. Here, we show that the skin microbiota promotes the discrete expression of defined
Noriko Mizusawa et al.
Islets, 14(1), 1-13 (2021-10-13)
The aim of this study was to identify genes that are specifically expressed in pancreatic islet β-cells (hereafter referred to as β-cells). Large-scale complementary DNA-sequencing analysis was performed for 3,429 expressed sequence tags derived from murine MIN6 β-cells, through homology
Etienne Delangre et al.
Cell death & disease, 12(12), 1136-1136 (2021-12-09)
Glucocorticoids (GCs) are widely prescribed for their anti-inflammatory and immunosuppressive properties as a treatment for a variety of diseases. The use of GCs is associated with important side effects, including diabetogenic effects. However, the underlying mechanisms of GC-mediated diabetogenic effects
Elisabetta Mereu et al.
Cancers, 15(8) (2023-05-16)
Proteasome inhibitors (PIs) are extensively used for the therapy of multiple myeloma. However, patients continuously relapse or are intrinsically resistant to this class of drugs. In addition, adverse toxic effects such as peripheral neuropathy and cardiotoxicity could arise. Here, to
Fang Han et al.
Investigative ophthalmology & visual science, 61(14), 24-24 (2020-12-22)
The purpose of this study was to explore the role of thymic stromal lymphopoietin (TSLP) secreted by Aspergillus fumigatus-stimulated dendritic cells (DCs) during the T helper 17 (Th17) immune response, and further clarify the mechanisms contributing to the Th17 immune
Gaofeng Wang et al.
Cell host & microbe, 29(5), 777-791 (2021-04-03)
Environmental factors that enhance regeneration are largely unknown. The immune system and microbiome are attributed roles in repairing and regenerating structure but their precise interplay is unclear. Here, we assessed the function of skin bacteria in wound healing and wound-induced
Vanda Póvoa et al.
Nature communications, 12(1), 1156-1156 (2021-02-21)
Cancer immunoediting is a dynamic process of crosstalk between tumor cells and the immune system. Herein, we explore the fast zebrafish xenograft model to investigate the innate immune contribution to this process. Using multiple breast and colorectal cancer cell lines
Marine Gros et al.
Cell reports, 40(7), 111205-111205 (2022-08-18)
Despite its crucial role in initiation of cytotoxic immune responses, the molecular pathways underlying antigen cross-presentation remain incompletely understood. The mechanism of antigen exit from endocytic compartments into the cytosol is a long-standing matter of controversy, confronting two main models:
Federica La Russa et al.
The Journal of investigative dermatology, 139(9), 1936-1945 (2019-04-12)
Increasing evidence suggests that nerve fibers responding to noxious stimuli (nociceptors) modulate immunity in a variety of tissues, including the skin. Yet, the role of nociceptors in regulating sterile cutaneous inflammation remains unexplored. To address this question, we have developed
Zahra Alvandi et al.
Journal of the American Heart Association, 11(7), e023695-e023695 (2022-03-30)
Background The onset and mechanisms of endothelial-to-mesenchymal transition (EndMT) in mitral valve (MV) leaflets following myocardial infarction (MI) are unknown, yet these events are closely linked to stiffening of leaflets and development of ischemic mitral regurgitation. We investigated whether circulating
Anna Śledzińska et al.
Immunity, 52(1), 151-166 (2020-01-12)
In addition to helper and regulatory potential, CD4+ T cells also acquire cytotoxic activity marked by granzyme B (GzmB) expression and the ability to promote rejection of established tumors. Here, we examined the molecular and cellular mechanisms underpinning the differentiation of
Cemre Celen et al.
Cell reports, 41(5), 111581-111581 (2022-11-03)
The dynamic regulation of β-cell abundance is poorly understood. Since chromatin remodeling plays critical roles in liver regeneration, these mechanisms could be generally important for regeneration in other tissues. Here, we show that the ARID1A mammalian SWI/SNF complex subunit is
Katharina Bergerhoff et al.
Methods in molecular biology (Clifton, N.J.), 2559, 51-63 (2022-10-01)
Besides their important function in immune homeostasis, autoimmunity, and peripheral tolerance, regulatory T cells (Tregs) also play a crucial role in cancer immune evasion, by assisting tumors to shield from antitumor responses by effector cells. Tregs are recruited to infiltrate
Immune checkpoint activity regulates polycystic kidney disease progression.
Kleczko, et al.
JCI insight, 8 (2023)
Patrice Zeis et al.
Immunity, 53(4), 775-792 (2020-10-02)
Innate lymphoid cells (ILCs) are generated early during ontogeny and persist predominantly as tissue-resident cells. Here, we examined how ILCs are maintained and renewed within tissues. We generated a single cell atlas of lung ILC2s and found that Il18r1+ ILCs
Adrian Filiberti et al.
Investigative ophthalmology & visual science, 61(10), 24-24 (2020-08-14)
Corneal opacity and neovascularization (NV) are often described as outcomes of severe herpes simplex virus type 1 (HSV-1) infection. The current study investigated the role of colony-stimulating factor 1 receptor (CSF1R)+ cells and soluble factors in the progression of HSV-1-induced
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