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显示 1-30 共 143 条结果 关于 "08-115" 范围 论文
Rongjing Song et al.
Gene, 529(1), 50-56 (2013-07-19)
The effect of mouse resistin on hepatic insulin resistance in vivo and in vitro, and its possible molecular mechanism were examined. Focusing on liver glycogen metabolism and gluconeogenesis, which are important parts of glucose metabolism, in primary cultures of rat
Eva van Ingen et al.
Human molecular genetics, 31(7), 1051-1066 (2021-10-22)
We have previously shown that C/D box small nucleolar RNAs (snoRNAs) transcribed from the DLK1-DIO3 locus on human chromosome 14 (14q32) are associated with cardiovascular disease. DLK1-DIO3 snoRNAs are 'orphan snoRNAs' that have no known targets. We aimed to identify
Sonya Ruiz-Torres et al.
Cell stem cell, 28(3), 424-435 (2020-11-25)
Squamous cell carcinoma (SCC) is a global public health burden originating in epidermal stem and progenitor cells (ESPCs) of the skin and mucosa. To understand how genetic risk factors contribute to SCC, studies of ESPC biology are imperative. Children with
Chiara Zambarda et al.
European journal of cell biology, 101(4), 151274-151274 (2022-09-25)
Several factors present in the extracellular environment regulate epithelial cell adhesion and dynamics. Among them, growth factors such as EGF, upon binding to their receptors at the cell surface, get internalized and directly activate the acto-myosin machinery. In this study
Ren Song et al.
Molecular therapy. Methods & clinical development, 27, 73-88 (2022-10-04)
A limitation for recombinant adeno-associated virus (rAAV)-mediated gene transfer into the central nervous system (CNS) is the low penetration of vectors across the human blood-brain barrier (BBB). High doses of intravenously delivered vector are required to reach the CNS, which
Alberto Pappalardo et al.
Advances in wound care, 10(9), 490-502 (2020-09-02)
Objective: We compared the capability of human umbilical vein endothelial cells (HUVECs), induced pluripotent stem cell (iPSC)-derived endothelial cells (iECs), and human dermal blood endothelial cells (HDBECs) to effectively vascularize engineered human skin constructs (HSCs) in vitro and on immunodeficient
Qiuyang Zhang et al.
American journal of physiology. Gastrointestinal and liver physiology, 322(6), G598-G614 (2022-04-06)
The pathogenesis of subsquamous intestinal metaplasia (SSIM), in which glands of Barrett's esophagus (BE) are buried under esophageal squamous epithelium, is unknown. In a rat model of reflux esophagitis, we found that columnar-lined esophagus developed via a wound-healing process involving
Rania Harati et al.
PloS one, 17(1), e0262152-e0262152 (2022-01-14)
The brain endothelial barrier permeability is governed by tight and adherens junction protein complexes that restrict paracellular permeability at the blood-brain barrier (BBB). Dysfunction of the inter-endothelial junctions has been implicated in neurological disorders such as multiple sclerosis, stroke and
Sejin Chung et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(7), 2290-2304 (2018-12-13)
Cancer cells often have deficiencies in cell-cycle control mechanisms and could be dependent on specific cell-cycle checkpoints to maintain viability. Because of the documented role of KRAS in driving replication stress, we targeted the checkpoint governing DNA replication using CHK1
H Uyttendaele et al.
Developmental biology, 196(2), 204-217 (1998-05-13)
Elongation and branching of epithelial ducts is a crucial event during the development of the mammary gland. Branching morphogenesis of the mouse mammary epithelial TAC-2 cell line was used as an assay to examine the role of Wnt, HGF, TGF-beta
Erik S Knudsen et al.
Oncogene, 38(18), 3355-3370 (2019-01-31)
Pancreatic ductal adenocarcinoma (PDAC), like many KRAS-driven tumors, preferentially loses CDKN2A that encodes an endogenous CDK4/6 inhibitor to bypass the RB-mediated cell cycle suppression. Analysis of a panel of patient-derived cell lines and matched xenografts indicated that many pancreatic cancers
Kuo-Sheng Hsu et al.
Nature communications, 13(1), 7078-7078 (2022-11-19)
Collagen I, the most abundant protein in humans, is ubiquitous in solid tumors where it provides a rich source of exploitable metabolic fuel for cancer cells. While tumor cells were unable to exploit collagen directly, here we show they can
Yichen Cheng et al.
Cell reports, 39(9), 110885-110885 (2022-06-02)
Physiological blood-tissue barriers play a critical role in separating the circulation from immune-privileged sites and denying access to blood-borne viruses. The mechanism of virus restriction by these barriers is poorly understood. We utilize induced pluripotent stem cell (iPSC)-derived human brain
The insulin receptor regulates the persistence of mechanical nociceptive sensitization in flies and mice.
Wang, et al.
Biology Open, 12 (2023)
Kimberley A Mander et al.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 32(2), 277-281 (2019-10-15)
Clostridium perfringens type D epsilon toxin (ETX) is responsible for a severe and frequently fatal neurologic disorder in ruminant livestock. Light microscopic, immunohistochemical, and ultrastructural studies have suggested that ETX injury to the cerebral microvasculature, with subsequent severe, generalized vasogenic
Esther T Stoeckli et al.
Current protocols in cell biology, 61, 9-9 (2014-02-11)
Cell-cell adhesion is a fundamental requirement for all multicellular organisms. The calcium-independent cell adhesion molecules of the immunoglobulin superfamily (IgSF-CAMs) represent a major subgroup. They consist of immunoglobulin folds alone or in combination with other protein modules, often fibronectin type-III
Paulina Moreno-Layseca et al.
Nature cell biology, 23(10), 1073-1084 (2021-10-08)
Spatially controlled, cargo-specific endocytosis is essential for development, tissue homeostasis and cancer invasion. Unlike cargo-specific clathrin-mediated endocytosis, the clathrin- and dynamin-independent endocytic pathway (CLIC-GEEC, CG pathway) is considered a bulk internalization route for the fluid phase, glycosylated membrane proteins and
Kacey Ronaldson-Bouchard et al.
Nature biomedical engineering, 6(4), 351-371 (2022-04-29)
Engineered tissues can be used to model human pathophysiology and test the efficacy and safety of drugs. Yet, to model whole-body physiology and systemic diseases, engineered tissues with preserved phenotypes need to physiologically communicate. Here we report the development and
Meng-Yin Yang et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(3), 618-628 (2014-06-27)
Three-dimensional (3-D) tissue engineered constructs provide a platform for examining how the local extracellular matrix contributes to the malignancy of various cancers, including human glioblastoma multiforme. Here, we describe a simple and innovative 3-D culture environment and assess its potential
J J Tomasek et al.
The Journal of biological chemistry, 272(11), 7482-7487 (1997-03-14)
Gelatinase A (GL-A) is a matrix metalloproteinase (MMP) involved in both connective tissue remodeling and tumor invasion. GL-A activation is mediated by a membrane-type MMP (MT-MMP) that cleaves the GL-A propeptide. In this study, we examined the role of the
Detailed Molecular Mechanism and Potential Drugs for COL1A1 in Carboplatin-Resistant Ovarian Cancer.
Feng Yang et al.
Frontiers in oncology, 10, 576565-576565 (2021-03-09)
Carboplatin resistance in ovarian cancer (OV) is a major medical problem. Thus, there is an urgent need to find novel therapeutic targets to improve the prognosis of patients with carboplatin-resistant OV. Accumulating evidence indicates that the gene COL1A1 (collagen type
Ricardo Monteiro et al.
Cells, 12(12) (2023-06-28)
Escherichia coli is a versatile commensal species of the animal gut that can also be a pathogen able to cause intestinal and extraintestinal infections. The plasticity of its genome has led to the evolution of pathogenic strains, which represent a
Jia Sun et al.
Redox biology, 39, 101811-101811 (2020-12-29)
Vascular complications of diabetes are a serious challenge in clinical practice, and effective treatments are an unmet clinical need. Acidic fibroblast growth factor (aFGF) has potent anti-oxidative properties and therefore has become a research focus for the treatment of diabetic
Ze-Hua Zhao et al.
Cellular and molecular gastroenterology and hepatology, 12(3), 857-871 (2021-05-15)
Butyric acid is an intestinal microbiota-produced short-chain fatty acid, which exerts salutary effects on alleviating nonalcoholic fatty liver disease (NAFLD). However, the underlying mechanism of butyrate on regulating hepatic lipid metabolism is largely unexplored. A mouse model of NAFLD was
Jing Li et al.
Journal of cellular and molecular medicine, 19(10), 2341-2351 (2015-07-16)
Autophagy, a type II programmed cell death, is essential for cell survival under stress, e.g. lung injury, and bone marrow-derived mesenchymal stem cells (BM-MSCs) have great potential for cell therapy. However, the mechanisms underlying the BM-MSC activation of autophagy to
Ignacio Fernando Hall et al.
EMBO molecular medicine, 13(10), e14060-e14060 (2021-09-23)
The role of single nucleotide polymorphisms (SNPs) in the etiopathogenesis of cardiovascular diseases is well known. The effect of SNPs on disease predisposition has been established not only for protein coding genes but also for genes encoding microRNAs (miRNAs). The
Da Li et al.
Nature communications, 11(1), 342-342 (2020-01-19)
Precise control of hepatic glucose production (HGP) is pivotal to maintain systemic glucose homeostasis. HNF4α functions to stimulate transcription of key gluconeogenic genes. HNF4α harbors two promoters (P2 and P1) thought to be primarily active in fetal and adult livers
Erik S Knudsen et al.
Gut, 70(1), 127-138 (2020-05-20)
This study exploits the intersection between molecular-targeted therapies and immune-checkpoint inhibition to define new means to treat pancreatic cancer. Patient-derived cell lines and xenograft models were used to define the response to CDK4/6 and MEK inhibition in the tumour compartment.
Carmen Gallego et al.
Frontiers in cellular and infection microbiology, 13, 1138232-1138232 (2023-06-01)
Human papillomaviruses (HPVs) are highly prevalent commensal viruses that require epithelial stratification to complete their replicative cycle. While HPV infections are most often asymptomatic, certain HPV types can cause lesions, that are usually benign. In rare cases, these infections may
Ching Chen et al.
Cardiovascular diabetology, 22(1), 172-172 (2023-07-08)
Higher chemokine C-X-C motif ligand 5 (CXCL5) level was observed in type 2 diabetes mellitus (DM) patients; however, its role in diabetic vasculopathy was not clarified. This study aimed to explore the impacts and mechanistic insights of CXCL5 in neovasculogenesis
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