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Tze Liang Goh et al.
The Medical journal of Australia, 194(11), 602-604 (2011-06-08)
In 2010, an immigrant from Burma was the first person to be diagnosed in New Zealand with extensively drug-resistant tuberculosis (XDR-TB). The strain of Mycobacterium tuberculosis is the most resistant reported to date in Australasia. Key difficulties of managing this
J Furin et al.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 17(9), 1239-1241 (2013-07-06)
Tens of thousands of children are sick with multidrug-resistant forms of tuberculosis (MDR-TB), but there are limited child-friendly delivery systems for second-line medications. This case study presents the development of a granular dosing spoon pediatric delivery system for para-aminosalicylic acid.
A C Liwa et al.
Journal of tropical pediatrics, 59(2), 90-94 (2012-11-24)
There are no paediatric data regarding slow-release para-aminosalicylic acid (PAS). We studied PAS plasma concentrations in 10 children receiving a single 150 mg/kg dose daily or 75 mg/kg twice daily and 12 adults receiving 4 g twice daily. Blood specimens
Amanda S Fivian-Hughes et al.
Microbiology (Reading, England), 158(Pt 2), 308-318 (2011-10-29)
Thymidylate synthase (TS) enzymes catalyse the biosynthesis of deoxythymidine monophosphate (dTMP or thymidylate), and so are important for DNA replication and repair. Two different types of TS proteins have been described (ThyA and ThyX), which have different enzymic mechanisms and
Sumit Chakraborty et al.
Science (New York, N.Y.), 339(6115), 88-91 (2012-11-03)
Folate biosynthesis is an established anti-infective target, and the antifolate para-aminosalicylic acid (PAS) was one of the first anti-infectives introduced into clinical practice on the basis of target-based drug discovery. Fifty years later, PAS continues to be used to treat
Dinamene Santos et al.
Biological trace element research, 152(1), 113-116 (2013-01-15)
Manganese (Mn) is an essential metal for biological systems; however, occupational or clinical exposure to high levels of Mn can produce a neurological disorder called manganism. Oxidative stress and neuroinflammation play major roles in the Mn-induced neurodegeneration leading to dysfunction
Drugs for inflammatory bowel disease.
Treatment guidelines from the Medical Letter, 10(115), 19-28 (2012-03-01)
Gaurav Vadnerkar et al.
Current drug discovery technologies, 10(1), 16-24 (2012-06-26)
Sterically hindered esters or esters of drugs with macromolecular carriers like dextran and cyclodextrin find wide applicability in colon-targeted delivery. We report here synthesis, in vitro release kinetics of macromolecular prodrug of 4-aminosalicylic acid (4-ASA) with β-cyclodextrin and its extensive
Cezary Chojnacki et al.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 31(182), 92-96 (2011-09-23)
In order to maintain ulcerative colitis (UC) in remission, chronic use of aminosalicylates is recommended. All patients have a fear of the recurrence of symptoms, which makes their mental state and quality of life worse. Because of this a number
A case of DRESS syndrome induced by the antituberculosis drugs, prothionamide, and para-aminosalycilic acid.
Joo-Hee Kim et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110(2), 118-119 (2013-01-29)
Jie Zhang et al.
Chemical biology & drug design, 78(4), 709-717 (2011-07-15)
Neuraminidase (NA) is a major glycoprotein of influenza virus which is essential for viral infection. It offers a potential target for antiviral drug design and discovery. To develop novel potent neuraminidase inhibitors (NAI), Surflex-Dock was employed to dock 40 hydrophobic
V E Sagynbaeva et al.
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (3)(3), 40-46 (2012-07-27)
Detection of IgM and IgG Chlamydia and Mycoplasma pneumoniae indicates an aggravation of intracellular infections, including, possibly, due to immunosuppressive therapy. It is possible that the intracellular infection may mediate the occurrence of certain extraintestinal manifestations of inflammatory bowel disease
Fuqiang An et al.
Journal of hazardous materials, 201-202, 74-81 (2011-12-16)
In this study, 5-aminosalicylic acid (5-ASA) was successfully grafted onto the poly(glycidyl methacrylate) (PGMA) macromolecular chains of PGMA/SiO(2) to obtain adsorbent ASA-PGMA/SiO(2). The adsorption properties of ASA-PGMA/SiO(2) for phenolic compounds were studied through batch and column methods. The experimental results
Diana Couto et al.
Redox report : communications in free radical research, 15(6), 259-267 (2011-01-07)
Sulfasalazine is a prodrug composed by a molecule of 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), linked by an azo bond, which has been shown to be effective in the therapy of inflammatory bowel diseases (IBD) such as ulcerative colitis and
A P Marreilha Dos Santos et al.
Toxicology and applied pharmacology, 258(3), 394-402 (2011-12-20)
Chronic, excessive exposure to manganese (Mn) may induce neurotoxicity and cause an irreversible brain disease, referred to as manganism. Efficacious therapies for the treatment of Mn are lacking, mandating the development of new interventions. The purpose of the present study
[A chronic moderate manganism poisoning treated with sodium p-aminosalicylic acid].
Wei-Ping Qin et al.
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 29(8), 619-620 (2012-02-18)
S M Vesenbeckh et al.
Infection, 40(2), 199-202 (2011-08-13)
para-Aminosalicylic acid (PAS) is commonly used in the treatment of drug-resistant tuberculosis, including multidrug-resistant tuberculosis. Since its first use in the 1940s, hypersensitivity reactions frequently limit its use in clinical practice. Cases of successful desensitization against PAS using orally administered
Shuichi Yano et al.
BMJ case reports, 2012, doi:10-doi:10 (2012-05-19)
Isoniazid (H) or rifampicin (R) mono-resistant disease can be treated easily and effectively with first-line drugs, while combined H and R resistance (ie, multidrug-resistant tuberculosis (MDRTB)) requires treatment with at least four agents, including a quinolone and an injectable agent.
Lan Hong et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(10), 1904-1909 (2011-07-20)
para-aminosalicylic acid (PAS; 4-amino-2-hydroxybenzoic acid), an antituberculosis drug in use since the 1950s, has recently been suggested to be an effective agent for treatment of manganese-induced parkinsonian disorders. However, the neuropharmacokinetics of PAS and its metabolite N-acetyl-para-aminosalicylic acid (AcPAS; N-acetyl-4-amino-2-hydroxybenzoic
V E Sagynbaeva et al.
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (3)(3), 47-58 (2012-07-27)
Chronic inflammation in IBD is accompanied by an imbalance in the production of Tx1 and Tx2 cytokines. Imbalance of cytokine profile is important pathogenetic importance in chronic inflammatory process, since the formation of defective immune response to pathogenic agent promotes
Kim S Sugamori et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(5), 882-890 (2011-02-15)
Human arylamine N-acetyltransferase 2 (NAT2) mediates the biotransformation of arylamine drugs and procarcinogens into either innocuous or reactive DNA-damaging metabolites and is expressed predominantly in liver. Interspecies differences and incongruous results between in vitro, in vivo, and epidemiological studies make
Fluoroquinolone-resistant tuberculosis at a medical centre in Taiwan, 2005-10.
Chih-Cheng Lai et al.
The Journal of antimicrobial chemotherapy, 66(10), 2437-2438 (2011-07-30)
Lan Hong et al.
Journal of pharmaceutical and biomedical analysis, 54(5), 1101-1109 (2010-12-17)
Para-aminosalicylic acid (PAS), an approved drug for treatment of tuberculosis, is a promising therapeutic agent for treatment of manganese (Mn)-induced parkinsonian syndromes. Lack of a quantifying method, however, has hindered the clinical evaluation of its efficacy and there upon new
Shadeed Gad et al.
The Journal of pharmacy and pharmacology, 64(9), 1264-1274 (2012-08-14)
The objective of this work was to spray dry p-aminosalicylic acid (PAS) and its ammonium salt and to investigate the impact of the pore-forming agent, ammonium carbonate (AC), on the morphological, aerodynamic and physicochemical properties of the resulting powders. Microparticles
S Thee et al.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 15(9), 1191-1193 (2011-09-29)
Ethionamide (ETH) treatment may cause hypothyroidism. Clinical data, serum thyroid stimulating hormone (TSH) and free thyroxine (fT4) levels were retrospectively assessed in 137 children receiving anti-tuberculosis treatment including ETH. Abnormal thyroid function tests (TFTs) were recorded in 79 (58%) children:
Bente Mertz Nørgård
Danish medical bulletin, 58(12), B4360-B4360 (2011-12-07)
The clinical epidemiological studies included in this thesis fall into three parts. The first part includes studies on birth outcome in women with ulcerative colitis. The second part includes pharmacoepidemiological studies on birth outcome after anti-inflammatory drug therapy in pregnancy
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