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Hana Vlčková et al.
Journal of separation science, 37(11), 1297-1307 (2014-03-22)
The retention behavior of a large group of analytes (35) with varied properties (pKa and logP) was studied on eight hydrophilic interaction LC columns with different surfaces, stationary phase chemistries, and types of particles. The acetonitrile content (5-95%), buffer concentration
Jin Woo Park et al.
Archives of pharmacal research, 37(12), 1560-1569 (2013-11-21)
Risedronate is widely used clinically to treat osteoporosis, Paget's disease, hypercalcemia, bone metastasis, and multiple myeloma. However, its oral efficacy is restricted due to its low bioavailability and severe gastrointestinal adverse effects. This study was designed to evaluate the effect
Haoyue Zhang et al.
Molecular genetics and metabolism, 114(2), 123-128 (2014-12-03)
Mucopolysaccharidoses (MPS) are complex storage disorders that result in the accumulation of glycosaminoglycans (GAGs) in urine, blood, brain and other tissues. Symptomatic patients are typically screened for MPS by analysis of GAG in urine. Current screening methods used in clinical
Tara Mastren et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 90, 117-121 (2014-04-09)
Effective specific activity of (64)Cu (amount of radioactivity per µmol metal) is important in order to determine purity of a particular (64)Cu lot and to assist in optimization of the purification process. Metal impurities can affect effective specific activity and
Lauriane Goldwirt et al.
Journal of neuro-oncology, 122(2), 273-281 (2015-03-22)
Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. Prognosis of GBM patients is poor with median overall survival around 15 months. Temozolomide is the chemotherapeutic agent used in the standard of care of newly diagnosed GBM
Kyounghwan Lee et al.
Journal of molecular biology, 427(2), 274-286 (2014-12-03)
Myosin binding protein C is a thick filament protein of vertebrate striated muscle. The cardiac isoform [cardiac myosin binding protein C (cMyBP-C)] is essential for normal cardiac function, and mutations in cMyBP-C cause cardiac muscle disease. The rod-shaped molecule is
Jana Paulsen et al.
Phytochemistry, 111, 149-153 (2015-02-11)
The genuine major benzylisoquinoline alkaloid occurring in the traditional medicinal plant greater celandine (Chelidonium majus L.) is 13,14-dihydrocoptisine and not - as described previously - coptisine. Structure of 13,14-dihydrocoptisine was elucidated. The discrepancy between the alkaloid pattern of the living
Srinivas Rao Chennamaneni et al.
Pharmaceutical research, 31(11), 3179-3190 (2014-06-21)
To advance therapy for the treatment of concurrent uveitis and post-cataract surgical inflammation; we evaluated pharmacokinetics and pharmacodynamics of Bioerodible Dexamethasone Implant (BDI) containing 0.3 mg of dexamethasone (DXM) in Concanavalin A (Con A) induced uveitis followed by phacoemulsification in
Harriet Mörtstedt et al.
Journal of proteome research, 14(2), 860-873 (2014-12-30)
Hairdressers have an increased risk for developing airway symptoms, for example, asthma and rhinitis. Persulfates, which are oxidizing agents in bleaching powder, are considered important causal agents for these symptoms. However, the underlying mechanisms are unclear. The aim was therefore
Karl B Scheidweiler et al.
Analytical and bioanalytical chemistry, 407(3), 883-897 (2014-09-17)
Clandestine laboratories constantly produce new synthetic cannabinoids to circumvent legislative scheduling efforts, challenging and complicating toxicological analysis. Sundstrom et al. (Anal Bioanal Chem 405(26):8463-8474, [9]) and Kronstrand et al. (Anal Bioanal Chem 406(15):3599-3609, [10]) published nontargeted liquid chromatography, high-resolution, quadrupole/time-of-flight
K Maráková et al.
Die Pharmazie, 69(9), 663-668 (2014-10-03)
The advanced hyphenated method based on capillary electrophoresis (CE) on-line combined with electrospray ionization (ESI) and tandem mass spectrometry (MS/MS, here triple quadrupole, QqQ) was developed and applied in pharmaceutical analysis in this work. Under the optimized CE separation (background
Zbynek Dzuman et al.
Analytica chimica acta, 863, 29-40 (2015-03-04)
A new reliable and highly sensitive method based on high performance liquid chromatographic (HPLC) separation and high resolution tandem mass spectrometric detection (HRMS/MS) has been developed and validated for determination of 323 pesticide residues, 55 mycotoxins, and 11 plant toxins
Jan Soukup et al.
Journal of chromatography. A, 1374, 102-111 (2014-12-30)
Excess adsorption of water from aqueous acetonitrile mobile phases was investigated on 16 stationary phases using the frontal analysis method and coulometric Karl-Fischer titration. The stationary phases include silica gel and silica-bonded phases with different polarities, octadecyl and cholesterol, phenyl
Robert Jirásko et al.
Analytical and bioanalytical chemistry, 406(19), 4601-4610 (2014-05-21)
The combination of ultrahigh-resolution mass spectrometry imaging (UHRMSI) and ultrahigh-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC/MS/MS) was used for the identification and the spatial localization of atorvastatin (AT) and its metabolites in rat tissues. Ultrahigh-resolution and high mass
Oskar Vilhelmsson-Timmermand et al.
Nuclear medicine and biology, 42(4), 375-380 (2015-01-13)
Human tumors xenografted in immunodeficient mice are crucial models in nuclear medicine to evaluate the effectiveness of candidate diagnostic and therapeutic compounds. However, little attention has been focused on the biological profile of the host model and its potential effects
Evgenia Karousou et al.
Molecules (Basel, Switzerland), 19(6), 7959-7980 (2014-06-14)
Glycosaminoglycans (GAGs) due to their hydrophilic character and high anionic charge densities play important roles in various (patho)physiological processes. The identification and quantification of GAGs in biological samples and tissues could be useful prognostic and diagnostic tools in pathological conditions.
Jérémy Carlier et al.
Journal of analytical toxicology, 38(9), 619-627 (2014-07-06)
Atractyloside (ATR) and carboxyatractyloside (CATR) are diterpene glycosides that are responsible for the toxicity of several Asteraceae plants around the world. Mediterranean gum thistle (Atractylis gummifera L.) and Zulu impila (Callilepis laureola DC.), in particular, are notoriously poisonous and the
Yuliang Zhang et al.
Preparative biochemistry & biotechnology, 43(2), 189-196 (2013-01-11)
[BPy]H(2)PO(4) was easily prepared and used as an efficient and recyclable catalyst for the one-pot synthesis of 2,4,5-trisubstituted imidazoles under solvent-free conditions in good to excellent yields. Solvent-free conditions, simple experimental and workup procedures, and the use of a nontoxic
Liangpo Liu et al.
Journal of separation science, 38(2), 247-253 (2014-11-12)
In this study, a novel method for the analysis of perfluorinated compounds in whole blood has been developed and validated. The method was developed by using a conventional reversed-phase C18 column as a trapping column for the elimination of background
Sara Castiglioni et al.
Journal of hazardous materials, 282, 51-60 (2014-07-06)
Perfluorinated substances are listed among emerging contaminants because they are globally distributed, environmentally persistent, bioaccumulative and potentially harmful. In a three-year monitoring campaign (2010-2013) we investigated the occurrence, sources and fate of nine perfluoroalkylcarboxylic acids and three perfluoroalkylsulfonic acids, in
Muzaffar Iqbal et al.
Journal of analytical toxicology, 39(2), 106-112 (2014-11-19)
Vilazodone is a novel antidepressant agent, approved by the US Food and Drug Administration (US FDA) for the treatment of major depressive disorder. In this study, a fast sensitive ultra-high performance liquid chromatography-tandem mass spectroscopy method was developed and validated
Suzanne L Parker et al.
Journal of pharmaceutical and biomedical analysis, 105, 39-45 (2014-12-22)
A high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method, using hydrophilic interaction liquid chromatography (HILIC) chromatography for the analysis of fosfomycin in human plasma and urine, has been developed and validated. The plasma method uses a simple protein precipitation using
Ali Athab Al-Kinani et al.
Analytical and bioanalytical chemistry, 407(9), 2645-2650 (2015-02-11)
Oxidative damage due to low levels of glutathione (GSH) is one of the main causes of cataract formation. It has been reported that 2-oxothiazolidine-4-carboxylic acid (OTZ), a cysteine prodrug, can increase the cellular level of GSH. Currently, there is no
Le Ngoc Tran et al.
Journal of chromatography. A, 1356, 289-293 (2014-07-20)
An organic-inorganic silica/zirconia hybrid monolithic capillary column was prepared by sol-gel process in a fused-silica capillary by using triethoxysilylpropylcarbamate (TEOSPC) derivative of clindamycin phosphate (CLIP) as a chiral selector. A sol solution consisting of 6 × 10(-3)M of polyethylene glycol
Eshwar Jagerdeo et al.
Journal of analytical toxicology, 39(2), 83-88 (2014-11-30)
The abuse of gamma-hydroxybutyric acid (GHB) and its suspicion in cases of suspected drug-facilitated sexual assault is of keen interest to forensic toxicology laboratories. This paper reports an extraction, separation and detection procedure for GHB in hair utilizing a combination
Serial in-solution digestion protocol for mass spectrometry-based glycomics and proteomics analysis.
Manveen K Sethi et al.
Molecular omics, 16(4), 364-376 (2020-04-21)
Advancement in mass spectrometry has revolutionized the field of proteomics. However, there remains a gap in the analysis of protein post-translational modifications (PTMs), particularly for glycosylation. Glycosylation, the most common form of PTM, is involved in most biological processes; thus
Michelle T Ma et al.
Dalton transactions (Cambridge, England : 2003), 44(11), 4884-4900 (2014-10-30)
Due to its long half-life (78 h) and decay properties (77% electron capture, 23% β(+), Emax = 897 keV, Eav = 397 keV, Eγ = 909 keV, Iγ = 100%) (89)Zr is an appealing radionuclide for immunoPET imaging with whole
Kuniko Mitamura et al.
Steroids, 85, 18-29 (2014-04-12)
A liquid chromatography (LC)/electrospray ionization (ESI)-mass spectrometry (MS) method for the direct determination of eighteen tetrahydrocorticosteroid sulfates in human urine has been developed. The analytes were 3- and 21-monosulfates and 3,21-disulfates of tetrahydrocortisol (THF), tetrahydrocortisone (THE), tetrahydro-11-deoxycortisol (THS), and their
David Moreno-González et al.
Journal of chromatography. A, 1360, 1-8 (2014-08-16)
In this work molecularly imprinted polymers have been evaluated as sorbent for the construction of an in-line solid phase extraction analyte concentrator in capillary electrophoresis coupled with mass spectrometry for the determination of the eight regulated veterinary quinolones in bovine
Mathias Devreese et al.
Journal of chromatography. A, 1353, 106-113 (2014-03-25)
A specific and sensitive LC-MS/MS method was developed for quantitative determination of closantel in bovine and ovine colostrum and tank milk. Sample preparation consisted of extracting milk samples with acetonitrile/acetone (80/20, v/v) followed by SPE clean-up with Oasis mixed anion
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