搜索范围
09691
应用筛选条件
关键词:'09691'
显示 1-30 #N/A 497 条结果 关于 "09691" 范围 论文
Dao-Jin Chen et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 969, 42-52 (2014-08-26)
Folk drug Gynostemma pentaphyllum (Thunb.) Makino contains many biologically active phytochemicals which have been demonstrated to be effective against chronic diseases. As in vivo anti-tumor experiments of G. pentaphyllum extract (GP) show much stronger antitumor activities than in vitro, it
Sarah Afshordel et al.
Pharmacological research, 91, 69-77 (2014-12-17)
Alterations in small GTPase mediated signal transduction pathways have emerged as a central step in the molecular pathogenesis of glioblastoma (GBM), the most common malignant brain tumor in adults. Farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP) are derived from mevalonate, whose production
Ugo Bussy et al.
Analytical and bioanalytical chemistry, 406(28), 7253-7260 (2014-09-23)
Electrochemistry combined with (liquid chromatography) high resolution mass spectrometry was used to simulate the general reductive metabolism of three biologically important nitro aromatic molecules: 3-trifluoromethyl-4-nitrophenol (TFM), niclosamide, and nilutamide. TFM is a pesticide used in the Laurential Great Lakes while
Leila Maringer et al.
Electrophoresis, 36(2), 348-354 (2014-10-14)
The combination of CE and MS is now a widely used tool that can provide a combination of high resolution separations with detailed structural information. Recently, we highlighted the benefits of an approach to add further functionality to this well-established
Charity Wayua et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(1), 113-119 (2014-12-17)
Tumor-specific targeting ligands were recently exploited to deliver both imaging and therapeutic agents selectively to cancer tissues in vivo. Because the cholecystokinin 2 receptor (CCK2R) is overexpressed in various human cancers (e.g., lung, medullary thyroid, pancreatic, colon, and gastrointestinal stromal
Marco Pistolozzi et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(3), 344-352 (2014-12-17)
This work describes the sequential hydrolysis of bambuterol enantiomers and their monocarbamate metabolites (MONO) catalyzed by human butyrylcholinesterase (BChE) as well as the enzyme inhibition resulting from this process. Particular emphasis is given to the contribution given by MONO to
Karri Visweswara Rao et al.
Journal of chromatographic science, 52(10), 1247-1254 (2014-01-30)
A simple, precise and accurate stability-indicating reversed phase-high performance liquid chromatography method was developed for the quantitative determination of O-desmethyl venlafaxine (ODV) and its related substances in active pharmaceutical ingredient and pharmaceutical formulation. The method was developed using YMC-pack ODS-A
Hao Jiang et al.
Journal of pharmaceutical and biomedical analysis, 107, 17-23 (2015-01-07)
BMS-791325 is a novel hepatitis C NS5B inhibitor which is currently in clinical development. To support pharmacokinetic (PK) assessments, sensitive, accurate, precise, and reproducible liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods have been developed and validated for the quantitation of BMS-791325
Anna C Susa et al.
Journal of the American Chemical Society, 136(37), 12912-12919 (2014-08-22)
Human islet amyloid polypeptide (hIAPP or Amylin) is a 37 residue hormone that is cosecreted with insulin from the pancreatic islets. The aggregation of hIAPP plays a role in the progression of type 2 diabetes and contributes to the failure
Jung-Hyuk Yim et al.
Analytical and bioanalytical chemistry, 406(18), 4401-4409 (2014-05-21)
Herein, we describe an accurate method for protein quantification based on conventional acid hydrolysis and an isotope dilution-ultra performance liquid chromatography-tandem mass spectrometry method. The analyte protein, recombinant human erythropoietin (rhEPO), was effectively hydrolyzed by incubation with 8 mol/L hydrochloric
Petter Olsson et al.
Journal of chromatography. A, 1369, 105-115 (2014-12-03)
This paper reports a simple chromatographic system to separate lipids classes as well as their molecular species. By the use of phenyl coated silica as stationary phase in combination with a simple mobile phase consisting of methanol and water, all
Yasuo Uchida et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1719-1726 (2014-07-26)
The purpose of this study was to demonstrate experimentally that alterations of in vivo transporter function at the blood-brain barrier (BBB) in disease and during pharmacotherapy can be reconstructed from in vitro data based on our established pharmacoproteomic concept of
Maarja-Liisa Oldekop et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 147-155 (2014-08-12)
For liquid chromatographic analysis of amino acids involving derivatization and mass-spectrometric detection, it becomes more important to evaluate the presence of matrix effects in complex samples. This is somewhat complicated for amino acid analysis where analyte free sample matrix is
Shengdong Pan et al.
Journal of chromatographic science, 53(1), 104-111 (2014-04-29)
A simple and sensitive ultrasonic-assisted extraction coupled with liquid chromatography-tandem quadrupole mass spectrometry was developed for the simultaneous determination of eight β2-agonists (i.e., phenylethanolamine, fenoterol, formoterol, clenbuterol, ractopamine, salbutamol, terbutaline and tulobuterol) in pork. The recovery rate of ultrasonic-assisted extraction
Priscilla B Pujatti et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 96, 91-101 (2014-12-06)
We evaluated and compared a new bombesin analog [Tyr-Gly5, Nle(14)]-BBN(6-14) conjugated to DOTA or DTPA and radiolabeled with In-111 in low and high GRPR expressing tumor models. Both peptides were radiolabeled with high radiochemical purity and specific activity. In vitro
I Sepil et al.
Journal of evolutionary biology, 28(3), 642-654 (2015-02-11)
Genes of the major histocompatibility complex (MHC) are regarded as a potentially important target of mate choice due to the fitness benefits that may be conferred to the offspring. According to the complementary genes hypothesis, females mate with MHC dissimilar
Irina S Moreira et al.
Journal of hazardous materials, 287, 93-101 (2015-01-28)
Fluoxetine (FLX) is a chiral fluorinated pharmaceutical mainly indicated for treatment of depression and is one of the most distributed drugs. There is a clear evidence of environmental contamination with this drug. Aerobic granular sludge sequencing batch reactors constitute a
Jheng-Jie Jiang et al.
Marine pollution bulletin, 85(2), 391-399 (2014-01-21)
This study provides a first estimate of the sources, distribution, and risk presented by emerging organic contaminants (EOCs) in coastal waters off southwestern Taiwan. Ten illicit drugs, seven nonsteroidal anti-inflammatory drugs (NSAIDs), five antibiotics, two blood lipid regulators, two antiepileptic
Hong Lin et al.
Journal of the American Society for Mass Spectrometry, 23(12), 2122-2131 (2012-09-21)
Electrospray ionization mass spectrometry (ESI-MS) measurements were performed under a variety of solution conditions on a highly acidic sub-fragment (B3C) of the C-terminal carbohydrate-binding repeat region of Clostridium difficile toxin B, and two mutants (B4A and B4B) containing fewer acidic
Sheng-Dong Pan et al.
Journal of chromatography. A, 1362, 34-42 (2014-08-28)
A novel planar-structure amine-functional magnetic polymer modified graphene oxide nanocomposite (NH2-MP@GO) was synthesized. The properties were characterized by transmission electron microscopy (TEM) and Fourier-transform infrared spectrometry (FTIR). The obtained adsorption results showed that the NH2-MP@GO had great adsorptive ability toward
Xuanfeng Yue et al.
Journal of the American Society for Mass Spectrometry, 25(8), 1322-1331 (2014-05-20)
The mechanisms whereby protein ions are liberated from charged droplets during electrospray ionization (ESI) remain under investigation. Compact conformers electrosprayed from aqueous solution in positive ion mode likely follow the charged residue model (CRM), which envisions analyte release after solvent
Jose M Knee et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 936, 63-73 (2013-09-06)
We report a method of ion-pairing liquid chromatography coupled to mass spectrometry (IP-LC-MS) that we have developed for the sensitive detection and quantification of a variety of biologically relevant polar molecules. We use the ion-pairing agent diamyl ammonium to improve
Rumi Tanoue et al.
Journal of chromatography. A, 1355, 193-205 (2014-06-25)
In the present study, a sensitive and accurate isotope dilution method was developed for the simultaneous determination of 17 polar pharmaceutical and personal care product (PPCP) residues (logKow=1.40-5.74), including 14 pharmaceuticals and 3 personal care products, in biological organs and
Balázs Bobály et al.
Talanta, 136, 60-67 (2015-02-24)
Trifluoroacetic acid (TFA) is commonly used as mobile phase additive for the analysis of proteins in reversed phase liquid chromatography (RPLC). Due to its interesting features, it provides symmetrical and narrow peak shapes for proteins, but decreases mass spectrometric sensitivity
P-S Bellaye et al.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 20(12), 1557-1570 (2018-05-20)
This study aimed to investigate theranostic strategies in colorectal and skin cancer based on fragments of cetuximab, an anti-EGFR mAb, labeled with radionuclide with imaging and therapeutic properties, 111In and 177Lu, respectively. We designed F(ab')2-fragments of cetuximab radiolabeled with 111In
Rémi Zallot et al.
ACS chemical biology, 9(8), 1812-1825 (2014-06-10)
Queuosine (Q) is a modification found at the wobble position of tRNAs with GUN anticodons. Although Q is present in most eukaryotes and bacteria, only bacteria can synthesize Q de novo. Eukaryotes acquire queuine (q), the free base of Q
H A S Murad et al.
Indian journal of pharmaceutical sciences, 76(3), 203-210 (2014-07-19)
This study was designed to study potentiation of fluoxetine's antidepressant effect by curcumin or pindolol. Twenty eight groups of mice (n=8) were used in three sets of experiments. In the first set, 9 groups were subjected to the forced swimming
Eric W Crick et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 57, 25-33 (2014-01-28)
The goal of this study was to use a status epilepticus steady-state chemical model in rats using the convulsant, 3-mercaptopropionic acid (3-MPA), and to compare the changes in striatal neurotransmission on a slow (5min) and fast (60s) timescale. In vivo
Sharon E Murphy et al.
Carcinogenesis, 35(11), 2526-2533 (2014-09-23)
Nicotine metabolism influences smoking behavior and differences in metabolism probably contribute to ethnic variability in lung cancer risk. We report here on the proportion of nicotine metabolism by cytochrome P450 2A6-catalyzed C-oxidation, UDP-glucuronosyl transferase 2B10 (UGT2B10)-catalyzed N-glucuronidation and flavin monooxygenase
Huiyong Wang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 980, 72-78 (2015-01-16)
Bile acids (BAs) have recently gained more attention because of their diverse roles from digestion to signaling. Simultaneous analyses of various BAs in biological samples are challenging due to their structural similarity, relatively low concentrations, and the presence of isomeric
1/17