101-99-5

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Blood pressure regulation by ETA and ETB receptors in conscious, telemetry-instrumented mice and role of ETA in hypertension produced by selective ETB blockade.

Ryan M Fryer et al.

American journal of physiology. Heart and circulatory physiology, 290(6), H2554-H2559 (2006-01-10)

The net contribution of endothelin type A (ET(A)) and type B (ET(B)) receptors in blood pressure regulation in humans and experimental animals, including the conscious mouse, remains undefined. Thus we assessed the role of ET(A) and ET(B) receptors in the

Efficacy of monthly tafenoquine for prophylaxis of Plasmodium vivax and multidrug-resistant P. falciparum malaria.

Douglas S Walsh et al.

The Journal of infectious diseases, 190(8), 1456-1463 (2004-09-21)

We assessed monthly doses of tafenoquine for preventing Plasmodium vivax and multidrug-resistant P. falciparum malaria. In a randomized, double-blind, placebo-controlled study, 205 Thai soldiers received either a loading dose of tafenoquine 400 mg (base) daily for 3 days, followed by

Congener specific analysis of polychlorinated biphenyls (PCBs) in serum using GC/MSD.

U S Gill et al.

Chemosphere, 30(10), 1969-1977 (1995-05-01)

A new congener specific method has been developed for extraction and quantitative determination of PCB contaminants of serum. After liquid-liquid extraction and chromatographic fractionation with Carbopack-C/florisil column, the analytes were identified and quantified utilizing gas chromatography/mass spectrometry (GC/MSD) using selected

Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers.

Daniel B Costa et al.

Lung cancer (Amsterdam, Netherlands), 58(1), 95-103 (2007-07-06)

Epidermal growth factor receptor (EGFR) mutations have been found in the majority of gefitinib-responsive non-small cell lung cancer (NSCLC) patients from retrospective studies. We sought to compile the available phase II and prospective trials of this EGFR tyrosine kinase inhibitor

Delta 32 mutation of the chemokine-receptor 5 gene in inflammatory bowel disease.

K Martin et al.

Clinical immunology (Orlando, Fla.), 98(1), 18-22 (2001-01-06)

The gene encoding chemokine receptor 5 (CCR5) is colocalized to the microsatellite marker D3S1573, which was linked with inflammatory bowel disease. Genetic heterogeneity in inflammatory bowel disease might be defined by a combination of the p-ANCA status and immunoregulatory genes.

Supercritical fluid extraction (SFE) of 4(5)-methylimidazole (4-MeI) and 2-acetyl-4(5)-(1,2,3,4)-tetrahydroxybutyl-imidazole (THI) from ground-coffee with high-performance liquid chromatographic-electrospray mass spectrometric quantification (HPLC/ESI-MS).

L Lojková et al.

Food additives and contaminants, 23(10), 963-973 (2006-09-20)

Two polar analytes, 4(5)-methylimidazole (4-MeI) and 2-acetyl-4(5)-(1,2,3,4)-tetrahydroxybutyl-imidazole (THI), were extracted with supercritical carbon dioxide (CO2) modified with aqueous methanol. The method was applied to a roasted coffee powder with good recovery rates. Method efficiency was compared with that of solid-phase

Antibodies directed to protein S in patients with systemic lupus erythematosus: prevalence and clinical significance.

Maria Laura Bertolaccini et al.

Thrombosis and haemostasis, 90(4), 636-641 (2003-09-30)

Antibodies directed against protein S (anti-ProtS) may be involved in the development of thrombosis in patients with the antiphospholipid syndrome. We assessed the prevalence and clinical significance of anti-ProtS and evaluated their immunological characteristics in 184 patients with SLE and

Anti-citrullinated glucose-6-phosphate isomerase peptide antibodies in patients with rheumatoid arthritis are associated with HLA-DRB1 shared epitope alleles and disease activity.

N Umeda et al.

Clinical and experimental immunology, 172(1), 44-53 (2013-03-14)

To identify and characterize anti-citrullinated glucose-6-phosphate isomerase (GPI) peptide antibodies in patients with rheumatoid arthritis (RA). Nine GPI arginine-bearing peptides in human GPI protein were selected and cyclic citrullinated GPI peptides (CCG-1-9) were constructed. Samples were obtained from RA (n = 208)

Expression of bovine myoglobin cDNA as a functionally active holoprotein in Saccharomyces cerevisiae.

H Shimada et al.

Journal of biochemistry, 105(3), 417-422 (1989-03-01)

We isolated a cDNA clone for myoglobin mRNA from fetal bovine skeletal muscle using a DNA fragment of human myoglobin exon 2 as a probe. The complete coding sequence of myoglobin as well as the 3'- and part of the

PROP1 gene screening in patients with multiple pituitary hormone deficiency reveals two sites of hypermutability and a high incidence of corticotroph deficiency.

S Vallette-Kasic et al.

The Journal of clinical endocrinology and metabolism, 86(9), 4529-4535 (2001-09-11)

Alterations of the gene encoding the pituitary transcription factor PROP1 were associated with congenital forms of multiple pituitary hormone deficiencies in several families. Among 23 patients with multiple pituitary hormone deficiencies screened for a PROP1 gene abnormality, nine belonging to

Solubilization and molecular characterization of the atrial natriuretic peptide (ANP) receptor in human platelets: comparison with ANP receptors in rat tissues.

E L Schiffrin et al.

The Journal of clinical endocrinology and metabolism, 72(2), 484-491 (1991-02-01)

We have previously demonstrated the presence of binding sites for atrial natriuretic peptide (ANP) in human platelets. These sites have pharmacological characteristics similar to those of rat vascular smooth muscle. They are subject to regulation by circulating levels of ANP

Improved method to measure urinary alkoxyacetic acids.

T S Shih et al.

Occupational and environmental medicine, 56(7), 460-467 (1999-09-03)

To simplify the current preparation of samples, and to improve the specificity and reliability of the conventional analytical methods to measure urinary alkoxyacetic acids. Samples containing alkoxyacetic acids including methoxy, ethoxy, and butoxyacetic acids (MAA, EAA, and BAA) were acidified

Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese.

Ronald Ching Wan Ma et al.

PloS one, 9(1), e84770-e84770 (2014-01-28)

In Asia, young-onset type 2 diabetes (YOD) is characterized by obesity and increased risk for cardiovascular disease (CVD). In a genome-wide association study (GWAS) of 99 Chinese obese subjects with familial YOD diagnosed before 40-year-old and 101 controls, the T

Effects of Storage and Granary Weevil Infestation on Gel Electrophoresis and Protein Solubility Properties of Hard and Soft Wheat Flours.

Sule Keskin et al.

Journal of economic entomology, 111(3), 1454-1460 (2018-03-13)

The objective of this study was to investigate the effects of storage and granary weevil, Sitophilus granarius (L.; Coleoptera: Curculionidae), infestation on pH, protein solubility (PS) and gel electrophoresis properties of meal and roller-milled flours of hard (Ceyhan-99 cv.) and

Occurrence and levels of organochlorine compounds in human breast milk in Bangladesh.

Charlotte Bergkvist et al.

Chemosphere, 88(7), 784-790 (2012-05-04)

In low-income countries, the use of some organochlorine pesticides is still common in order to increase food production. Monitoring the chemical exposure is an important step in risk-reducing strategies. This is the first study to report concentrations of organochlorines in

Creation of a restrictive atrial communication in pulmonary arterial hypertension (PAH): effective palliation of syncope and end-stage heart failure.

Anna Bauer et al.

Pulmonary circulation, 8(2), 2045894018776518-2045894018776518 (2018-04-26)

Atrial septostomy (AS) is recommended for pulmonary arterial hypertension (PAH)-associated right ventricular (RV) failure, recurrent syncope, or pulmonary hypertensive crisis (PHC). We aimed to evaluate the feasibility and efficacy of AS to manage PAH from infancy to adulthood. From June

Utilization of amino acid analogues in diets of young turkeys.

C M Parsons et al.

The British journal of nutrition, 46(1), 77-86 (1981-07-01)

1. The relative potencies of three lysine, one tryptophan and six methionine analogues to their corresponding l-amino acids were determined. 2. Male poults, 9 d of age, were used in five 14 d experiments. Experimental diets were formed by adding

Human mast cells expressing recombinant proteinase 3 (PR3) as substrate for clinical testing for anti-neutrophil cytoplasmic antibodies (ANCA).

U Specks et al.

Clinical and experimental immunology, 109(2), 286-295 (1997-08-01)

We have expressed conformationally intact, enzymatically active recombinant PR3 in HMC-1 cells (HMC-1/PR3 cells) that is recognized by C-ANCA. Here we directly compared the clinical utility of C-ANCA testing by indirect immunofluorescence (IIF) using HMC-1/PR3 cell cytospin versus polymorphonuclear neutrophil

99mTc(CO)3-nitrilotriacetic acid: a new renal radiopharmaceutical showing pharmacokinetic properties in rats comparable to those of 131I-OIH.

Malgorzata Lipowska et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 50(3), 454-460 (2009-02-19)

To develop a (99m)Tc renal tracer with a capacity to measure effective renal plasma flow comparable to that of the clinical gold standard (131)I-o-iodohippurate ((131)I-OIH) and superior to that of (99m)TcO-mercaptoacetyltriglycine, which has a clearance only 50%-60% that of (131)I-OIH

Gastric cancer-associated enhancement of von Willebrand factor is regulated by vascular endothelial growth factor and related to disease severity.

Xia Yang et al.

BMC cancer, 15, 80-80 (2015-04-18)

von Willebrand factor (vWF) is a potent regulator of angiogenesis, tumor growth, and metastasis. Yet, the expression pattern of vWF in human gastric cancer (GC) tissues and its relation to clinicopathological features of these cases remains unknown. Tumor and 5-cm

Determination of serum amantadine by liquid chromatography-tandem mass spectrometry.

Torsten Arndt et al.

Clinica chimica acta; international journal of clinical chemistry, 359(1-2), 125-131 (2005-05-26)

Amantadine (1-adamantylamine) is used for treatment of influenza, hepatitis C, parkinsonism, and multiple sclerosis. Current amantadine analysis by HPLC or gas chromatography (GC) requires a laborious sample pretreatment with extraction and/or derivatization steps. We established an LC-MS/MS method without protein

Systemic hypotensive effects of testosterone are androgen structure-specific and neuronal nitric oxide synthase-dependent.

Mercedes Perusquía et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 309(2), R189-R195 (2015-05-08)

Testosterone (TES) and other androgens exert a direct vasorelaxing action on the vasculature in vitro that is structurally specific and independent of cytosolic androgen receptor (AR). The effects of intravenous androgen infusions on mean arterial blood pressure (BP) and heart

Retinal oximetry.

Sveinn Hakon Hardarson

Acta ophthalmologica, 91 Thesis 2, 1-47 (2013-03-09)

ABSTRACT.: Malfunction of retinal blood flow or oxygenation is believed to be involved in various diseases. Among them are retinal vessel occlusions, diabetic retinopathy and glaucoma. Reliable, non-invasive technology for retinal oxygen measurements has been scarce and most of the

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