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Philippe A Guy et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(31), 3965-3974 (2009-11-03)
A validated method was developed for the simultaneous determination of the hydroxycinnamates caffeic acid (CA), dihydrocaffeic acid (DHCA), ferulic acid (FA), dihydroferulic acid (DHFA), and isoferulic acid (IFA) in human plasma as metabolites derived from coffee consumption. The method includes
Dimitra Hadjipavlou-Litina et al.
Bioorganic & medicinal chemistry, 18(23), 8204-8217 (2010-11-03)
A series of symmetric and asymmetric spermine (SPM) conjugates with all-trans-retinoic acid (ATRA), acitretin (ACI), (E)-3-(trioxsalen-4'-yl)acrylic acid (TRAA) and L-DOPA, amides of ACI, l-DOPA and TRAA with 1-aminobutane, benzylamine, dopamine and 1,12-diaminobutane as well as hybrid conjugates of O,O'-dimethylcaffeic acid
María Monagas et al.
The British journal of nutrition, 102(2), 201-206 (2009-07-10)
Oligomers and polymers of flavan-3-ols (proanthocyanidins) are very abundant in the Mediterranean diet, but are poorly absorbed. However, when these polyphenols reach the colon, they are metabolised by the intestinal microbiota into various phenolic acids, including phenylpropionic, phenylacetic and benzoic
Marian Raghubir et al.
Oncology reports, 43(1), 169-176 (2019-12-04)
Osteosarcomas are the most commonly occurring malignant bone cancer in young individuals. The survival rate of patients with metastatic osteosarcoma is low and has been stagnant for over two decades. We previously demonstrated that the glutamate release inhibitor, riluzole inhibits
Jing Guo et al.
Journal of the science of food and agriculture, 99(4), 1635-1642 (2018-09-08)
To study the effect of polyphenols on the release of aroma compounds in apple cider, the impact of (-)-epicatechin, hydrocaffeic acid and phloridzin on volatility of 12 typical aroma compounds was investigated by headspace solid phase microextraction and gas chromatography-mass
Juana I Mosele et al.
Journal of agricultural and food chemistry, 66(34), 8966-8975 (2018-08-07)
Among cereals, barley ( Hordeum vulgare L.) is notable for its high content of bioactives such as β-glucan and phenolic compounds, but it is not used as widely in human nutrition as wheat. To compare the impact of food formulation
Fernanda M F Roleira et al.
Bioorganic & medicinal chemistry, 18(16), 5816-5825 (2010-07-24)
Lipophilic compounds structurally based on caffeic, hydrocaffeic, ferulic and hydroferulic acids were synthesized. Subsequently, their antioxidant activity was evaluated as well as their partition coefficients and redox potentials. The structure-property-activity relationship (SPAR) results revealed the existence of a clear correlation
Brian Crow et al.
Biomedical chromatography : BMC, 22(12), 1346-1353 (2008-07-26)
The separation and detection of 11 urinary aromatic acids was developed using HPLC-MS/MS. The method features a simple sample preparation involving a single-step dilution with internal standard and a rapid 8 min chromatographic separation. The accuracy was evaluated by the
Hongzhi Qiao et al.
Biomaterials, 35(25), 7157-7171 (2014-05-28)
Renal fibrosis is a common progressive kidney disease, and there is a lack of efficient treatment for the condition. In this study, we designed a kidney-specific nanocomplex by forming coordination-driven assembly from catechol-derived low molecular weight chitosan (HCA-Chi), metal ions
Yang Li et al.
Journal of agricultural and food chemistry, 63(30), 6764-6771 (2015-07-18)
Echinacoside (ECH) is one of the representative phenylethanoid glycosides. It is widely present in plants and exhibits various bioactivities. However, the extremely low oral bioavailability of ECH in rats implies that ECH may go through multiple hydrolysis steps in the
Gonzalo García et al.
Journal of medicinal chemistry, 52(22), 7220-7227 (2009-10-30)
We report the first examples of a new series of antioxidant-sartan hybrids (AO-sartans), which were made by adding an antioxidant fragment to the hydroxymethyl side chain of losartan. Experiments performed in cultured cells demonstrate that these new hybrids retain the
S Vickers et al.
Journal of medicinal chemistry, 18(2), 134-138 (1975-02-01)
Major urinary metabolites of carbidopa have been identified. Estimates were made based on the recovery or radio activity or by glc analysis of pooled urine of the amounts of the urinary metabolites II (2-methyl-3'-methoxy-4'-hydroxyphenylpropionic acid), III (2-methyl-3,4-dihydroxyphenylpropionic acid), IV (3,4-dihydroxyphenylacetone)
M A González-Martínez et al.
Analytical and bioanalytical chemistry, 384(7-8), 1540-1547 (2006-02-28)
A comparative study of enzymatic and non-enzymatic labels combined with luminescence detection, developed for immunosensing of pesticide residues (carbaryl, 1-naphthol, irgarol 1051) in organic media, is presented. Peroxidase and alkaline phosphatase enzymes with fluorogenic (3-p-hydroxyphenylpropanoic acid) and luminogenic (AMPPD derivative)
Yutaka Konishi et al.
Journal of agricultural and food chemistry, 52(21), 6418-6424 (2004-10-14)
It was previously reported that m-coumaric acid, m-hydroxyphenylpropionic acid (mHPP), and 3,4-dihydroxyphenylpropionic acid (DHPP) are major metabolites of ingested caffeic acid formed by gut microflora and would be transported by the monocarboxylic acid transporter (MCT). We have directly measured their
Gema Pereira-Caro et al.
Free radical biology & medicine, 160, 784-795 (2020-09-15)
The health benefits of orange juice (OJ) consumption are attributed in part to the circulating flavanone phase II metabolites and their microbial-derived ring fission phenolic catabolites. The present study investigated these compounds in the bloodstream after acute intake of 500 mL
Abhishek Jain et al.
Scientific reports, 9(1), 9191-9191 (2019-06-27)
Gut microbiome plays a vital role in human health. Human fecal and urine metabolome could provide a functional readout of gut microbial metabolism as well as its interaction with host and diet. However, this relationship still needs to be fully
Ji Hyun Ryu et al.
Journal of controlled release : official journal of the Controlled Release Society, 317, 57-66 (2019-11-13)
Oral mucosal drug delivery systems have been developed to expedite the regeneration of oral mucosa, there are still many challenges related to residence time for drugs because the ceaseless changes of saliva, mouth movement, and involuntary swallowing prevent robust adhesion
Hye-Jin Kim et al.
Journal of medicinal food, 13(4), 808-814 (2010-06-18)
This study was performed to compare the hypolipidemic and antioxidant efficacy of hesperetin and its metabolites in hypercholesterolemic hamsters. The hamsters were fed a high-fat (10% coconut oil and 0.2% cholesterol, wt/wt) diet or a high-fat diet supplemented with hesperetin
Vy Anh Tran et al.
International journal of nanomedicine, 15, 7667-7685 (2020-10-30)
Core-shell types of mesoporous silica nanoparticles (MSNs) with multimodal functionalities were developed for bio-imaging, controlled drug release associated with external pH, and near-infrared radiation (NIR) stimuli, and targeted and effective chemo-photothermal therapeutics. We synthesized and developed a core-shell type of
Violetta Mohos et al.
Biomolecules, 10(3) (2020-03-12)
Flavonoids are abundant polyphenols in nature. They are extensively biotransformed in enterocytes and hepatocytes, where conjugated (methyl, sulfate, and glucuronide) metabolites are formed. However, bacterial microflora in the human intestines also metabolize flavonoids, resulting in the production of smaller phenolic
Benjamin Dilberger et al.
Nutrients, 11(8) (2019-08-16)
(1) Background: Polyphenols (PP) play an important role in the prevention of non-communicable diseases and may contribute to healthy aging. To investigate the molecular and cellular aspects of PP metabolites on longevity with a focus on mitochondrial function, we applied
Athinoula L Petrou et al.
Journal of inorganic biochemistry, 98(1), 123-132 (2003-12-09)
The reaction of 3,4-dihydroxyphenylpropionic acid (dihydrocaffeic acid, hydcafH3) with chromium(III) in weak acidic aqueous solutions has been shown to take place through various oxygen-bonded intermediates. The formation of the oxygen-bonded complexes upon substitution of water molecules of the chromium(III) coordination
Mireia Urpi-Sarda et al.
Journal of chromatography. A, 1216(43), 7258-7267 (2009-08-13)
The biological properties of cocoa (Theobroma cacao L.) polyphenols are strictly dependent on their bioavailability. A long-term cocoa feeding trial was performed with subjects at high risk for cardiovascular disease. Subjects (n=42) received two sachets of 20 g of cocoa
Gonzalo García et al.
European journal of medicinal chemistry, 50, 90-101 (2012-02-18)
We report new examples of a series of losartan-hydrocaffeic hybrids that bear novel ester, amide and amine linkers. These compounds were made by linking hydrocaffeic acid to the side chain of losartan at the C-5 position of the imidazole ring
Jing Li et al.
Biomaterials science, 6(1), 179-188 (2017-11-25)
Kidney-specific delivery is critically important for the treatment of renal fibrosis with drugs such as salvianolic acid B (Sal B). Here we report a kidney-specific nanocomplex formed by the coordination-driven assembly of catechol-modified low molecular weight chitosan (HCA-Chi), calcium ions
Xiaofei Huang et al.
Scientific reports, 7(1), 1860-1860 (2017-05-14)
In this study, silver nanoparticles (Ag NPs) coated with catechol-conjugated chitosan (CSS) were prepared using green methods. Interestingly, we uncovered that CSS-coated Ag NPs (CSS-Ag NPs) exhibited a higher toxicity against gram-negative Escherichia coli (E. coli) bacteria than against gram-positive
Sebastiaan P van Kessel et al.
BMC biology, 18(1), 137-137 (2020-10-21)
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Gastrointestinal tract dysfunction is one of the non-motor features, where constipation is reported as the most common gastrointestinal symptom. Aromatic bacterial metabolites are attracting considerable
Jong Min Lee et al.
Biomaterials, 39, 173-181 (2014-12-04)
A new design concept in controlled release chemistry is reported in this study. Unlike current depots that release drugs in all direction by an isotropic way, we demonstrate that directional release only to a clinically beneficial direction results in improved
Jose Luis Muñoz-Muñoz et al.
Acta biochimica Polonica, 58(3), 303-311 (2011-09-03)
Tyrosinase shows kinetic cooperativity in its action on o-diphenols, but not when it acts on monophenols, confirming that the slow step is the hydroxylation of monophenols to o-diphenols. This model can be generalised to a wide range of substrates; for
Kyuichi Kawabata et al.
Bioscience, biotechnology, and biochemistry, 79(5), 799-807 (2015-02-28)
Probiotics have been shown to improve the condition of not only the human gastrointestinal tract but also the entire body. We found that quercetin enhances the anti-inflammatory activity of Bifidobacterium adolescentis, which is abundant in human intestines. Here, we assessed
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