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Sebastiaan P van Kessel et al.
BMC biology, 18(1), 137-137 (2020-10-21)
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Gastrointestinal tract dysfunction is one of the non-motor features, where constipation is reported as the most common gastrointestinal symptom. Aromatic bacterial metabolites are attracting considerable
Gonzalo García et al.
Journal of medicinal chemistry, 52(22), 7220-7227 (2009-10-30)
We report the first examples of a new series of antioxidant-sartan hybrids (AO-sartans), which were made by adding an antioxidant fragment to the hydroxymethyl side chain of losartan. Experiments performed in cultured cells demonstrate that these new hybrids retain the
Yang Li et al.
Journal of agricultural and food chemistry, 63(30), 6764-6771 (2015-07-18)
Echinacoside (ECH) is one of the representative phenylethanoid glycosides. It is widely present in plants and exhibits various bioactivities. However, the extremely low oral bioavailability of ECH in rats implies that ECH may go through multiple hydrolysis steps in the
Athinoula L Petrou et al.
Journal of inorganic biochemistry, 98(1), 123-132 (2003-12-09)
The reaction of 3,4-dihydroxyphenylpropionic acid (dihydrocaffeic acid, hydcafH3) with chromium(III) in weak acidic aqueous solutions has been shown to take place through various oxygen-bonded intermediates. The formation of the oxygen-bonded complexes upon substitution of water molecules of the chromium(III) coordination
Chaemyeong Lee et al.
Scientific reports, 7(1), 13797-13797 (2017-10-25)
Inspired by adhesive mussel proteins, nanospherical self-assemblies were prepared from bolaamphiphiles containing 3,4-dihydroxyphenylalanine (DOPA) moieties, and a suspension of the bolaamphiphile assemblies was used for the preparation of a patterned surface that enhanced cell adhesion and viability. The abundant surface-exposed
Jose Luis Muñoz-Muñoz et al.
Acta biochimica Polonica, 58(3), 303-311 (2011-09-03)
Tyrosinase shows kinetic cooperativity in its action on o-diphenols, but not when it acts on monophenols, confirming that the slow step is the hydroxylation of monophenols to o-diphenols. This model can be generalised to a wide range of substrates; for
Ferdinand A van Dorsten et al.
Molecular nutrition & food research, 54(7), 897-908 (2009-12-17)
The metabolic impact of polyphenol-rich red wine and grape juice consumption in humans was studied using a metabolomics approach. Fifty-eight men and women participated in a placebo-controlled, double-crossover study in which they consumed during a period of 4 wk, either
Marian Raghubir et al.
Oncology reports, 43(1), 169-176 (2019-12-04)
Osteosarcomas are the most commonly occurring malignant bone cancer in young individuals. The survival rate of patients with metastatic osteosarcoma is low and has been stagnant for over two decades. We previously demonstrated that the glutamate release inhibitor, riluzole inhibits
Brian Crow et al.
Biomedical chromatography : BMC, 22(12), 1346-1353 (2008-07-26)
The separation and detection of 11 urinary aromatic acids was developed using HPLC-MS/MS. The method features a simple sample preparation involving a single-step dilution with internal standard and a rapid 8 min chromatographic separation. The accuracy was evaluated by the
Gamze Bora-Tatar et al.
Bioorganic & medicinal chemistry, 17(14), 5219-5228 (2009-06-13)
In the light of known HDAC inhibitors, 33 carboxylic acid derivatives were tested to understand the structural requirements for HDAC inhibition activity. Several modifications were applied to develop the structure-activity relationships of carboxylic acid HDAC inhibitors. HDAC inhibition activities were
Gianluca Etienne et al.
Advanced materials (Deerfield Beach, Fla.), 31(27), e1808233-e1808233 (2019-05-14)
Microcapsules are often used as individually dispersed carriers of active ingredients to prolong their shelf life or to protect premature reactions with substances contained in the surrounding. This study goes beyond this application and employs microcapsules as principal building blocks
Jong Min Lee et al.
Biomaterials, 39, 173-181 (2014-12-04)
A new design concept in controlled release chemistry is reported in this study. Unlike current depots that release drugs in all direction by an isotropic way, we demonstrate that directional release only to a clinically beneficial direction results in improved
Kyuichi Kawabata et al.
Bioscience, biotechnology, and biochemistry, 79(5), 799-807 (2015-02-28)
Probiotics have been shown to improve the condition of not only the human gastrointestinal tract but also the entire body. We found that quercetin enhances the anti-inflammatory activity of Bifidobacterium adolescentis, which is abundant in human intestines. Here, we assessed
Kazuaki Shinomiya et al.
European journal of pharmacology, 504(3), 185-189 (2004-11-16)
The effect of chlorogenic acid on the sleep-wakefulness cycle in rats was investigated in comparison with those of caffeic acid (the metabolite of chlorogenic acid) and dihydrocaffeic acid (the metabolite of caffeic acid). A significant prolongation of sleep latency was
Carrie E Brubaker et al.
Biomacromolecules, 12(12), 4326-4334 (2011-11-09)
Mussel-inspired adhesive hydrogels represent innovative candidate medical sealants or glues. In the present work, we describe an enzyme-degradable mussel-inspired adhesive hydrogel formulation, achieved by incorporating minimal elastase substrate peptide Ala-Ala into the branched poly(ethylene glycol) (PEG) macromonomer structure. The system
Violetta Mohos et al.
International journal of molecular sciences, 20(11) (2019-06-05)
Quercetin is an abundant flavonoid in nature and is used in several dietary supplements. Although quercetin is extensively metabolized by human enzymes and the colonic microflora, we have only few data regarding the pharmacokinetic interactions of its metabolites. Therefore, we
Gonzalo García et al.
European journal of medicinal chemistry, 50, 90-101 (2012-02-18)
We report new examples of a series of losartan-hydrocaffeic hybrids that bear novel ester, amide and amine linkers. These compounds were made by linking hydrocaffeic acid to the side chain of losartan at the C-5 position of the imidazole ring
Xiaofei Huang et al.
Scientific reports, 7(1), 1860-1860 (2017-05-14)
In this study, silver nanoparticles (Ag NPs) coated with catechol-conjugated chitosan (CSS) were prepared using green methods. Interestingly, we uncovered that CSS-coated Ag NPs (CSS-Ag NPs) exhibited a higher toxicity against gram-negative Escherichia coli (E. coli) bacteria than against gram-positive
Hyojun Park et al.
Biomaterials, 171, 164-177 (2018-04-27)
Intraportal pancreatic islet transplantation incurs huge cell losses during its early stages due to instant blood-mediated inflammatory reactions (IBMIRs), which may also drive regulation of the adaptive immune system. Therefore, a method that evades IBMIR will improve clinical islet transplantation.
Andrea Amato et al.
Carbohydrate polymers, 179, 273-281 (2017-11-08)
Protein mussel-inspired adhesive polymers, characterized by the presence of catechol groups, possess superior muco-adhesive properties and have great potentiality in wound healing. Suitable materials for wound dressing should properly combine muco-adhesiveness and antimicrobial activity. In this work, catechol-functionalized chitosan was
Mireia Urpi-Sarda et al.
Journal of chromatography. A, 1216(43), 7258-7267 (2009-08-13)
The biological properties of cocoa (Theobroma cacao L.) polyphenols are strictly dependent on their bioavailability. A long-term cocoa feeding trial was performed with subjects at high risk for cardiovascular disease. Subjects (n=42) received two sachets of 20 g of cocoa
Jing Li et al.
Biomaterials science, 6(1), 179-188 (2017-11-25)
Kidney-specific delivery is critically important for the treatment of renal fibrosis with drugs such as salvianolic acid B (Sal B). Here we report a kidney-specific nanocomplex formed by the coordination-driven assembly of catechol-modified low molecular weight chitosan (HCA-Chi), calcium ions
Zhiyong Yang et al.
Biotechnology letters, 33(4), 673-679 (2010-12-02)
A novel approach is reported for the synthesis of dihydrocaffoylated glycerols that consists of two steps: enzymatic synthesis of octyl dihydrocaffeate (as a synthetic intermediate) from octanol and dihydrocaffeic acid, and enzymatic interesterification of triacylglycerols with octyl dihydrocaffeate. Due to
Hye-Jin Kim et al.
Journal of medicinal food, 13(4), 808-814 (2010-06-18)
This study was performed to compare the hypolipidemic and antioxidant efficacy of hesperetin and its metabolites in hypercholesterolemic hamsters. The hamsters were fed a high-fat (10% coconut oil and 0.2% cholesterol, wt/wt) diet or a high-fat diet supplemented with hesperetin
Gema Pereira-Caro et al.
Free radical biology & medicine, 160, 784-795 (2020-09-15)
The health benefits of orange juice (OJ) consumption are attributed in part to the circulating flavanone phase II metabolites and their microbial-derived ring fission phenolic catabolites. The present study investigated these compounds in the bloodstream after acute intake of 500 mL
S Vickers et al.
Journal of medicinal chemistry, 18(2), 134-138 (1975-02-01)
Major urinary metabolites of carbidopa have been identified. Estimates were made based on the recovery or radio activity or by glc analysis of pooled urine of the amounts of the urinary metabolites II (2-methyl-3'-methoxy-4'-hydroxyphenylpropionic acid), III (2-methyl-3,4-dihydroxyphenylpropionic acid), IV (3,4-dihydroxyphenylacetone)
M A González-Martínez et al.
Analytical and bioanalytical chemistry, 384(7-8), 1540-1547 (2006-02-28)
A comparative study of enzymatic and non-enzymatic labels combined with luminescence detection, developed for immunosensing of pesticide residues (carbaryl, 1-naphthol, irgarol 1051) in organic media, is presented. Peroxidase and alkaline phosphatase enzymes with fluorogenic (3-p-hydroxyphenylpropanoic acid) and luminogenic (AMPPD derivative)
Vy Anh Tran et al.
International journal of nanomedicine, 15, 7667-7685 (2020-10-30)
Core-shell types of mesoporous silica nanoparticles (MSNs) with multimodal functionalities were developed for bio-imaging, controlled drug release associated with external pH, and near-infrared radiation (NIR) stimuli, and targeted and effective chemo-photothermal therapeutics. We synthesized and developed a core-shell type of
Benjamin Dilberger et al.
Nutrients, 11(8) (2019-08-16)
(1) Background: Polyphenols (PP) play an important role in the prevention of non-communicable diseases and may contribute to healthy aging. To investigate the molecular and cellular aspects of PP metabolites on longevity with a focus on mitochondrial function, we applied
Ji Hyun Ryu et al.
Journal of controlled release : official journal of the Controlled Release Society, 317, 57-66 (2019-11-13)
Oral mucosal drug delivery systems have been developed to expedite the regeneration of oral mucosa, there are still many challenges related to residence time for drugs because the ceaseless changes of saliva, mouth movement, and involuntary swallowing prevent robust adhesion
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