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显示 1-30 共 95 条结果 关于 "103-24-2" 范围 论文
Mahmoud Toulany et al.
Oncotarget, 7(28), 43746-43761 (2016-06-02)
Despite the significant contribution of radiotherapy to non-small lung cancer (NSCLC), radioresistance still occurs. One of the major radioresistance mechanisms is the hyperactivation of the PI3K/Akt pathway in which Akt facilitates the repair of DNA double-strand breaks (DSBs) through the
Ewa Lucia Gregoraszczuk et al.
Endocrine regulations, 39(2), 33-41 (2005-10-19)
To compare the effects on ovarian function of low chlorinated polychlorinated biphenyls (PCBs) mixture generally distributed at a faster rate and metabolised to a greater extent (Delor 103) with high chlorinated PCBs mixture which are accumulated in large amounts in
Hua Zhang et al.
Zhonghua yi xue za zhi, 87(34), 2390-2393 (2007-11-27)
To investigate the effect of single nucleotide polymorphism (SNP) + 45 of the adiponectin (ADIPOQ) gene on the response to therapy with rosiglitazone maleate in patients with type 2 diabetes. A total of 103 newly diagnosed type 2 diabetes patients
Diego Pinha Alves da Paz et al.
Evidence-based complementary and alternative medicine : eCAM, 2020, 4093206-4093206 (2020-08-01)
Euphorbia tirucalli Lineu (Euphorbiaceae) is a tropical and subtropical ornamental and toxic plant. E. tirucalli produces a latex that is commonly used to treat neoplasms. This study aimed to evaluate the effects of diluted E. tirucalli latex (DETL) on human
Mahmoud Toulany et al.
Cancer biology & therapy, 15(3), 317-328 (2013-12-20)
K-RAS mutated (K-RASmut) non-small cell lung cancer (NSCLC) cells are resistant to EGFR targeting strategies. We investigated the impact of K-RAS activity irrespective of mutational status in the EGFR-independent increase in clonogenic cell survival. An analysis of the K-RAS activity
Kathryn Futrega et al.
Communications biology, 4(1), 29-29 (2021-01-06)
Virtually all bone marrow-derived stromal cell (BMSC) chondrogenic induction cultures include greater than 2 weeks exposure to transforming growth factor-β (TGF-β), but fail to generate cartilage-like tissue suitable for joint repair. Herein we used a micro-pellet model (5 × 103 BMSC each)
Daniel M Moreira et al.
The Journal of urology, 190(6), 2106-2111 (2013-06-15)
We determined the accuracy of 24-hour urinalysis in predicting stone type and identify the associations between 24-hour urine elements with stone type. We performed a retrospective review of 503 stone formers with stone composition analysis and 24-hour urinalysis available. Analysis
Baolong Li et al.
Food & function, 6(6), 1984-1991 (2015-05-27)
Sulforaphane (SFN), which is an isothiocyanate (ITC) that is found in cruciferous vegetables, has received considerable attention because of its beneficial effects. In this study, the protection by SFN in the lysophosphatidylcholine (LPC)-induced injury of human vascular endothelial EA.hy.926 cells
Svetlana E Nikoulina et al.
Diabetes, 51(7), 2190-2198 (2002-06-28)
Glycogen synthase kinase (GSK)-3 has been implicated in the regulation of multiple cellular physiological processes in skeletal muscle. Selective cell-permeable reversible inhibitors (INHs) of GSK-3 (CT98014 and CHIR98023 [Chiron, Emeryville, CA] and LiCl) were used to evaluate the role of
Limei Liu et al.
Molecular and cellular biochemistry, 322(1-2), 87-91 (2008-11-08)
The aim of the present study was to evaluate the relationship of the manganese superoxide dismutase (MnSOD) Val16Ala (V16A) polymorphism with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) in Chinese patients, a case-control study was performed. This case-control
C S Ananda Kumar et al.
European journal of medicinal chemistry, 44(3), 1223-1229 (2008-11-01)
In order to explore the antiproliferative effect associated with the piperazine framework, several 1-benzhydrylpiperazine derivatives 8(a-d), 9(a-d) and 10(a-h) were synthesized. Variation in the functional group at N-terminal of the piperazine led to three sets of compounds, bearing the sulfonyl
Lixia Pei et al.
Journal of mass spectrometry : JMS, 47(8), 962-968 (2012-08-18)
A sensitive rapid analytical method was established and validated to determine the bakkenolide A (BA) in rat plasma. This method was further applied to assess the pharmacokinetics of BA in rats receiving a single dose of BA. Liquid chromatography tandem
Sebastian Heck et al.
Neuroimmunomodulation, 24(6), 331-340 (2018-04-24)
The chemokine CXCL12 interacting with the CXC receptor 4 (CXCR4) has been reported to play a role in the development and progression of bronchial asthma, but its mechanism of action is still unknown. The objective of this study was to
Rasmus Dreier et al.
Basic & clinical pharmacology & toxicology, 118(2), 128-135 (2015-08-15)
Obesity is a strong risk factor for hypertension, but the mechanism linking obesity to hypertension is not fully elucidated. In obesity, circulating concentrations of adiponectin are decreased and hypoadiponectinaemia has in some but not all studies been associated with increased
Bruce Kirkham et al.
Clinical and experimental rheumatology, 33(1), 11-19 (2014-12-24)
The present paper aims to investigate the effect of psoriatic arthritis (PsA) disease duration on the outcome of treatment with etanercept (ETN) in patients with PsA who also have moderate-to-severe psoriasis. Patients from the PRESTA trial who received ≥1 ETN
H Yamada et al.
The Japanese journal of human genetics, 40(2), 177-184 (1995-06-01)
Extracellular-superoxide dismutase (EC-SOD) is one of the SOD isozymes mainly distributed in the extracellular fluid. In the vascular system, it is located on the endothelial cell surface according to studies on the heparin binding capacity. By measurement of serum EC-SOD
Martin Müller et al.
Polymers, 10(12) (2019-04-10)
Thermoresponsive coatings of poly(N-isopropylacrylamide-co-DMAEMA)/cellulose sulfate (PNIPAM-DMAEMA/CS) complexes are reported eluting bone-morphogenetic-protein-2 (BMP-2) on demand relevant for implant assisted local bone healing. PNIPAM-DMAEMA/CS dispersions contained colloid particles with hydrodynamic radii RH = 170⁻288 nm at T = 25 °C shrinking to
Venkata Suresh Ponnuru et al.
Analytical and bioanalytical chemistry, 401(8), 2539-2548 (2011-09-06)
Authors developed a simple, sensitive, selective, rapid, rugged, and reproducible liquid chromatography-tandem mass spectrometry method for the quantification of eletriptan (EP) in human plasma using naratriptan (NP) as an internal standard (IS). Chromatographic separation was performed on Ascentis Express C18
Eric D Shin et al.
Gastroenterology, 128(5), 1340-1353 (2005-05-12)
Our understanding of the intestinotropic actions of glucagon-like peptide-2 (GLP-2)(1-33) is based on pharmacologic studies involving exogenous administration. However, the physiologic role of GLP-2 in mucosal growth and adaptation to nutritional stimulation remains poorly understood. The properties of GLP-2(3-33), a
Vanessa Lalonde-Robert et al.
Journal of the American Association for Laboratory Animal Science : JAALAS, 51(4), 464-468 (2012-10-10)
We evaluated the anesthetic efficacy of MS222 (dose, 1 or 2 g/L; pH 7) administered as an immersion bath (duration, 20 min) for nonbreeding female Xenopus leavis frogs (n = 33; average body weight, 103 ± 16 g). The acid
Tomas Gichner et al.
Mutation research, 657(2), 140-145 (2008-10-07)
Tobacco seedlings (Nicotiana tabacum var. xanthi) were treated for 24 h with mono-(2- and 3-CBA), di-(2,5- and 3,4-CBA), and tri-(2,4,6- and 2,3,5-CBA)-chlorobenzoic acids (CBAs) and with the mixture of polychlorinated biphenyls--Delor 103, or cultivated for 1 or 2 weeks in
Neslihan Aygün Kocabaş et al.
Archives of toxicology, 76(11), 643-649 (2002-11-05)
Epidemiological studies indicate that most risk factors for breast cancer are related to reproductive and hormonal factors. Estrogen has been proposed to trigger breast cancer development via an initiating mechanism involving its metabolite, catechol estrogen (CE). Because of the important
Ching-Hua Hsieh et al.
Journal of biomedical science, 19, 69-69 (2012-08-02)
Lipopolysaccharide (LPS) is recognized as the most potent microbial mediator presaging the threat of invasion of Gram-negative bacteria that implicated in the pathogenesis of sepsis and septic shock. This study was designed to examine the microRNA (miRNA) expression in whole
Ji-Young Park et al.
Journal of clinical pharmacology, 46(1), 109-114 (2006-01-07)
The authors evaluated the effect of high-dose aspirin at a therapeutic dose, using chlorzoxazone as a probe for CYP2E1 enzyme activity. In a randomized, open-label, 2-way crossover study, 10 healthy men were treated 3 times daily for 6 days with
Misook Min et al.
ACS applied materials & interfaces, 12(9), 10809-10819 (2020-02-19)
The synthesis of solution-processed two-dimensional (2D) layered organohalide (CH3(CH2)3NH3)2(CH3NH3)n-1Pb n
M Akiyama et al.
The British journal of ophthalmology, 92(9), 1293-1296 (2008-08-30)
The aim of this study was to investigate the association between normal tension glaucoma and the candidate disease locus glaucoma 1, open angle, B (GLC1B) on chromosome 2. There are many reports describing the results of association or linkage studies
Michèle Y Doucet et al.
Journal of the American Veterinary Medical Association, 232(1), 91-97 (2008-01-03)
To compare efficacy and safety of paste formulations of firocoxib and phenylbutazone in horses with naturally occurring osteoarthritis. Randomized controlled clinical trial. 253 client-owned horses with naturally occurring osteoarthritis. Horses were treated with firocoxib (0.1 mg/kg [0.045 mg/lb], PO, q
Camilla L Asferg et al.
American journal of hypertension, 27(10), 1301-1307 (2014-03-13)
Low-grade chronic inflammation is a characteristic feature of obesity, the most important lifestyle risk factor for hypertension. Elevated plasma concentrations of the inflammatory biomarker C-reactive protein (CRP) are associated with an increased risk of hypertension, but elevated plasma CRP concentrations
Pedro Gonzales et al.
PloS one, 15(3), e0228433-e0228433 (2020-03-07)
HIV disproportionately affects men who have sex with men (MSM) and transgender women (TW). These populations use alcohol more heavily than the general population, and alcohol use disorders (AUDs) are more prevalent among them. Naltrexone (NTX) has documented efficacy and
Laura Riccetti et al.
Frontiers in endocrinology, 10, 503-503 (2019-08-10)
Recombinant follicle-stimulating hormone (FSH) (follitropin alfa) and biosimilar preparations are available for clinical use. They have specific FSH activity and a unique glycosylation profile dependent on source cells. The aim of the study is to compare the originator (reference) follitropin
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