103-72-0

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Plasma FGF21 displays a circadian rhythm during a 72-h fast in healthy female volunteers.

Birgitte Andersen et al.

Clinical endocrinology, 75(4), 514-519 (2011-04-28)

Fibroblast growth factor (FGF21) is a potent regulator of glucose and lipid metabolism. In rodents, the hepatic expression of FGF21 is controlled by fasting and a circadian regulation, but the physiological role and regulation of FGF21 in humans is not

Bortezomib reinduction chemotherapy in high-risk ALL in first relapse: a report from the Children's Oncology Group.

Terzah M Horton et al.

British journal of haematology, 186(2), 274-285 (2019-04-09)

While survival in paediatric acute lymphoblastic leukaemia (ALL) is excellent, survival following relapse is poor. Previous studies suggest proteasome inhibition with chemotherapy improves relapse ALL response rates. This phase 2 Children's Oncology Group study tested the hypothesis that adding the

eNOS4 polymorphism of the endothelial nitric oxide synthase predicts risk for severe diabetic retinopathy.

M J Taverna et al.

Diabetic medicine : a journal of the British Diabetic Association, 19(3), 240-245 (2002-03-29)

Genetic factors may be involved in the development, and particularly in the severity, of diabetic retinopathy (DR), in addition to chronic hyperglycaemia. Increased nitric oxide generation has been suggested to play a significant role in the pathogenesis of DR. To

Humoral immune response to antigens of Porphyromonas gingivalis ATCC 33277 in chronic periodontitis.

Mônica Franca et al.

Journal of applied oral science : revista FOB, 15(3), 213-219 (2007-06-01)

Periodontitis is a chronic disease that results from an interaction of a mixed bacterial challenge and the host response. The purposes of this study were to evaluate the IgG serum levels to Porphyromonas gingivalis antigens by ELISA in individuals with

Pediatric hypophosphatasia: lessons learned from a retrospective single-center chart review of 50 children.

Marius Vogt et al.

Orphanet journal of rare diseases, 15(1), 212-212 (2020-08-20)

Hypophosphatasia (HPP) is a rare, inherited metabolic disorder caused by loss-of-function mutations in the ALPL gene that encodes the tissue-nonspecific alkaline phosphatase TNAP (ORPHA 436). Its clinical presentation is highly heterogeneous with a remarkably wide-ranging severity. HPP affects patients of

Frequency, determinants and outcome of elevated troponin in acute ischemic stroke patients.

Jan F Scheitz et al.

International journal of cardiology, 157(2), 239-242 (2012-02-14)

Myocardial injury indicated by elevation of cardiac troponins (cTnT) can be observed in acute ischemic stroke patients. Frequency, determinants and prognostic value are still unsettled. We performed a retrospective analysis including all consecutive ischemic stroke patients admitted to our stroke

Post-Prandial Protein Handling: You Are What You Just Ate.

Bart B L Groen et al.

PloS one, 10(11), e0141582-e0141582 (2015-11-12)

Protein turnover in skeletal muscle tissue is highly responsive to nutrient intake in healthy adults. To provide a comprehensive overview of post-prandial protein handling, ranging from dietary protein digestion and amino acid absorption, the uptake of dietary protein derived amino

Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options.

Ira M Jacobson et al.

The New England journal of medicine, 368(20), 1867-1877 (2013-04-24)

Patients chronically infected with hepatitis C virus (HCV) genotype 2 or 3 for whom treatment with peginterferon is not an option, or who have not had a response to prior interferon treatment, currently have no approved treatment options. In phase

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