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Hans-Peter Marti et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 29(6), 1177-1185 (2014-02-27)
We have previously described a transcriptomic classifier consisting of metzincins and related genes (MARGS) discriminating kidneys and other organs with or without fibrosis from human biopsies. We now apply our MARGS-based algorithm to a rat model of age-associated interstitial renal
Hanne H F Refsgaard et al.
Journal of medicinal chemistry, 48(3), 805-811 (2005-02-04)
A data set consisting of 712 compounds was used for classification into two classes with respect to membrane permeation in a cell-based assay: (0) apparent permeability (P(app)) below 4 x 10(-6) cm/s and (1) P(app) on 4 x 10(-6) cm/s
Selma Ugurel et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 13(21), 6344-6350 (2007-11-03)
The microphthalmia-associated transcription factor (MITF) is regarded as a key oncogene of the melanocytic lineage since it was detected by a genome-wide analysis to be strongly amplified in 15% to 20% of metastatic melanomas. MITF gene amplification was shown to
Justin P Rubio et al.
Immunogenetics, 59(3), 177-186 (2007-01-27)
Human leucocyte antigen (HLA)-DRB1*15 is associated with predisposition to multiple sclerosis (MS), although conjecture surrounds the possible involvement of an alternate risk locus in the class I region of the HLA complex. We have shown previously that an alternate MS
A Xanthopoulos et al.
International journal of cardiology, 230, 248-254 (2017-01-08)
The use of many acute heart failure (AHF) risk scores is cumbersome. We therefore developed a simple AHF risk score (AHFRS) for early risk stratification. The study consisted of a prospective derivation cohort (PDC; N=104; age, 77[21] years; LVEF (%)
Youping Wang et al.
American journal of physiology. Heart and circulatory physiology, 287(4), H1868-H1874 (2004-06-19)
To determine the role of endothelin-1 (ET-1) and its receptors in the regulation of calcitonin gene-related peptide (CGRP) release, male Wistar rats were divided into six groups and subjected to the following treatments for 1 wk with or without ABT-627
Sandra Guerra Xavier et al.
Digestive diseases and sciences, 55(6), 1770-1777 (2009-08-20)
Splanchnic vein thrombosis can be the presenting manifestation of myeloproliferative neoplasms. However, the diagnosis of a myeloproliferative neoplasm in these patients is often problematic, and more objective criteria are needed. To determine the frequency of the mutation JAK2V617F in patients
Jenjira Saichanapan et al.
Talanta, 212, 120788-120788 (2020-03-03)
This work presents a new material, i.e., a porous graphene ink to modify on the GCE surface (PGr-ink/GCE) to improve sensitivity by increasing the surface area of the electrode for the electrochemical determination of sibutramine. The surface characterization and electrochemical
Peng Wang et al.
American journal of clinical pathology, 134(4), 604-612 (2010-09-22)
We immunohistochemically evaluated UTF1 in 104 primary and 68 metastatic testicular germ cell tumors and 339 non-germ cell tumors. The percentage of tumor cells stained was semiquantitatively scored (0, no tumor cell staining; 1+, ≤30% of cells; 2+, 31%-60% of
D R Buckler et al.
Biochemistry, 34(49), 15965-15978 (1995-12-12)
Formation of local structure and overall chain dimensions in the 124-residue, four-disulfide protein bovine pancreatic ribonuclease A (RNase A) under conditions favoring either the native or partially folded states have been studied by nonradiative excitation energy transfer measurements. Three RNase
R M Palmer et al.
The British journal of nutrition, 79(4), 351-357 (1998-06-13)
From days 4-104 of pregnancy, adolescent sheep, weighing 43.7 (SE 0.87) kg were offered a complete diet at two different intakes (approximately 5 or 15 kg/week) designed to meet slightly, or well above, maternal maintenance requirements. The fetal and maternal
Karin Vered et al.
BMC genomics, 15, 865-865 (2014-10-07)
Klebsiella pneumoniae (Kp) is a bacterium causing severe pneumonia in immunocompromised hosts and is often associated with sepsis. With the rise of antibiotic resistant bacteria, there is a need for new effective and affordable control methods; understanding the genetic architecture
Nils Milman et al.
The clinical respiratory journal, 1(2), 74-79 (2007-12-01)
Distinct mutations of the caspase activating recruitment domain 15 (CARD15) gene (also known as nucleotide-binding oligomerisation domain protein 2) on chromosome 16q are associated with the chronic granulomatous disease called Blau syndrome. Sarcoidosis is a systemic granulomatous disease, which has
V Samuel et al.
Nigerian journal of clinical practice, 20(11), 1404-1410 (2018-01-06)
There are only limited studies that have determined the antibacterial effects of various remineralizing agents that can be beneficial to children. The aim of this study is to compare the efficacy of tricalcium phosphate (TCP), calcium sodium phosphosilicate (CSP), and
Yovana Sanchis et al.
Talanta, 202, 42-50 (2019-06-07)
A new strategy for the analysis of 4 parabens (methylparaben, ethyl paraben, propyl paraben and butyl paraben) and 3 bisphenols (A, F and S) in human urine has been developed. Dilute and shoot and liquid chromatography coupled to mass spectrometry
D S Stein et al.
Antimicrobial agents and chemotherapy, 35(9), 1705-1709 (1991-09-01)
We conducted an open prospective clinical trial to evaluate the efficacy and toxicity of trimethoprim-sulfamethoxazole given as one double-strength tablet thrice weekly for primary and secondary prophylaxis of Pneumocystis carinii pneumonia (PCP) in human immunodeficiency virus-infected (HIV+) patients. A total
Qaiser Bashir et al.
The Lancet. Haematology, 6(5), e266-e275 (2019-03-27)
Retrospective studies suggest that conditioning therapy with busulfan plus melphalan could result in longer progression-free survival compared with melphalan alone in patients with multiple myeloma undergoing autologous haemopoietic cell transplantation (auto-HCT). We aimed to test this hypothesis in a randomised
Richard B Lipton et al.
Headache, 60(1), 58-70 (2019-10-28)
The objective of this study was to evaluate the efficacy, tolerability, and safety of 120 mg DFN-15 vs placebo for the acute treatment of migraine. Certain nonsteroidal anti-inflammatory drugs (NSAIDs) are guideline-recommended therapies for the acute treatment of migraine, but patients
Marilyn J Cipolla et al.
Journal of applied physiology (Bethesda, Md. : 1985), 117(1), 53-59 (2014-05-03)
Brain parenchymal arterioles (PAs) are high-resistance vessels that branch off pial arteries and perfuse the brain parenchyma. PAs are the target of cerebral small vessel disease and have been shown to have greater pressure-induced tone at lower pressures than pial
Eric D Donnenfeld et al.
American journal of ophthalmology, 152(4), 609-617 (2011-06-28)
To compare the effects of 2 corticosteroids on corneal thickness and visual acuity after cataract surgery. Multicenter, randomized, contralateral-eye, double-masked trial. Fifty-two patients (104 eyes) underwent bilateral phacoemulsification. The first eye randomly received difluprednate 0.05% or prednisolone acetate 1%; the
Masayuki Yoshida et al.
British journal of cancer, 113(8), 1244-1248 (2015-09-12)
Phyllodes tumors are rare fibroepithelial neoplasms of the breast, which carry the potential risk of local recurrence and metastasis. Phyllodes tumors share several histological features with fibroadenomas, and no widely accepted markers for distinguishing these lesions have been identified. We
Chathura Kumaragamage et al.
Magnetic resonance in medicine, 83(5), 1539-1552 (2019-11-20)
The robust and reliable utilization of proton magnetic resonance spectroscopic imaging (MRSI) at high fields is hampered by several key technical difficulties, including contamination from extracranial lipids. To that end, this work presents novel lipid suppression sequences for proton MRSI
Degui Zhi et al.
Journal of human genetics, 60(2), 63-67 (2014-12-17)
Carotid intima-media thickness (cIMT) is a subclinical measure of atherosclerosis with mounting evidence that higher cIMT confers an increased risk of cardiovascular disease. The ryanodine receptor 3 gene (RYR3) has previously been linked to increased cIMT; however, the causal variants
Rachel A Moore et al.
The ISME journal, 15(2), 461-472 (2020-10-04)
The environmental sources of microbial aerosols and processes by which they are emitted into the atmosphere are not well characterized. In this study we analyzed microbial cells and biological ice nucleating particles (INPs) in smoke emitted from eight prescribed wildland
Laurent Barandon et al.
Circulation, 108(18), 2282-2289 (2003-10-29)
FrzA/sFRP-1, a secreted, frizzled-related protein and antagonist for the wnt/frizzled pathway, is expressed in the heart and vessels during mouse embryogenesis and adulthood. FrzA is involved in cell cycle control of vascular cells and angiogenesis. We assessed the hypothesis that
Ingolf Mølle et al.
European journal of haematology, 77(1), 19-26 (2006-07-11)
To study a possible association between mannan-binding lectin genotypes and severe infections in patients with multiple myeloma receiving moderate strength induction chemotherapy. Chemotherapy-related infections were identified retrospectively using clinical records and database files. Mannan-binding lectin genotypes were identified with polymerase
Plinio Carta et al.
Giornale italiano di medicina del lavoro ed ergonomia, 35(1), 32-35 (2013-06-27)
In several recent epidemiological studies blood lead levels (BLLs) even below the current CDC intervention level of 10 microg/dl have been associated with reduced neurocognitive capacities of children, with no clear evidence of a "safe" threshold. We analyzed the relationship
A C Lossie et al.
Journal of medical genetics, 38(12), 834-845 (2001-12-19)
Angelman syndrome (AS) is a severe neurobehavioural disorder caused by defects in the maternally derived imprinted domain located on 15q11-q13. Most patients acquire AS by one of five mechanisms: (1) a large interstitial deletion of 15q11-q13; (2) paternal uniparental disomy
Yves Sznajer et al.
Pediatrics, 119(6), e1325-e1331 (2007-05-23)
Noonan syndrome is a clinically homogeneous but genetically heterogeneous condition. Type 1 Noonan syndrome is defined by the presence of a mutation in the PTPN11 gene, which is found in approximately 40% of the cases. Phenotype descriptions and cardiac defects
James E Klaunig et al.
Toxicologic pathology, 43(2), 209-220 (2014-11-08)
Perfluorohexanoic acid (PFHxA), a 6-carbon perfluoroalkyl (C6; CAS # 307-24-4), has been proposed as a replacement for the commonly used 8-carbon perfluoroalkyls: perfluorooctanoic acid and perfluorooctane sulfonate. PFHxA is not currently a commercial product but rather the ultimate degradation product
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