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显示 1-30 共 125 条结果 关于 "104043" 范围 论文
Mridula Dwivedi et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 144, 105211-105211 (2020-01-14)
Polysorbate is one of the most commonly employed non-ionic surfactant in protein containing biological formulations, whereby, it can stabilize these biomolecules under different stress conditions. Despite the fact that polysorbates are present in almost 70% of currently marketed parenteral biological
L Cao-Hoang et al.
Applied microbiology and biotechnology, 79(1), 105-109 (2008-03-05)
The effect of rapid and slow chilling on survival and nisin sensitivity was investigated in Escherichia coli. Membrane permeabilization induced by cold shock was assessed by uptake of the fluorescent dye 1-N-phenylnapthylamine. Slow chilling (2 degrees C min(-1)) did not
Daniel Pletzer et al.
PLoS pathogens, 14(6), e1007084-e1007084 (2018-06-22)
With the antibiotic development pipeline running dry, many fear that we might soon run out of treatment options. High-density infections are particularly difficult to treat due to their adaptive multidrug-resistance and currently there are no therapies that adequately address this
Su Jin Ko et al.
Scientific reports, 7(1), 16580-16580 (2017-12-01)
The abuse of antibiotics for disease treatment has led to the emergence of multidrug resistant bacteria. Antimicrobial peptides, found naturally in various organisms, have received increasing interest as alternatives to conventional antibiotics because of their broad spectrum antimicrobial activity and
Wei Hong et al.
Journal of nanobiotechnology, 16(1), 66-66 (2018-09-13)
Although assemblies of hydrophobic-modified bacitracin A with PLGA (Nano-BAPLGA) have demonstrated promising antibacterial activities against both Gram-positive and Gram-negative bacteria, the desirable antibacterial potency has remained challenging due to the low solubility of Nano-BAPLGA. To address this tissue, a series
Lei Wang et al.
Veterinary microbiology, 243, 108634-108634 (2020-04-11)
Actinobacillus pleuropneumoniae is the causative agent of highly contagious and fatal respiratory infections, causing substantial economic losses to the global pig industry. Due to increased antibiotic resistance, there is an urgent need to find new antibiotic alternatives for treating A.
Isaac Ofori et al.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 52(7), 598-606 (2017-03-17)
This study investigated the kinetics and mechanism of chlorine dioxide (ClO
Silvia Spinelli et al.
Insect biochemistry and molecular biology, 42(1), 41-50 (2011-11-15)
Apis mellifera (Amel) relies on its olfactory system to detect and identify new-sources of floral food. The Odorant-Binding Proteins (OBPs) are the first proteins involved in odorant recognition and interaction, before activation of the olfactory receptors. The Amel genome possess
Seongok Kim et al.
Scientific reports, 8(1), 835-835 (2018-01-18)
Cronobacter sakazakii is an opportunistic pathogen that can cause meningitis and necrotizing enterocolitis in premature infants, but its virulence determinants remain largely unknown. In this study, a transposon-mediated random-mutant library of C. sakazakii was used to identify new virulence factors.
Kayli Hill et al.
Advanced healthcare materials, 9(4), e1900750-e1900750 (2020-01-17)
Conventional hemodialysis (HD) uses floor-standing instruments and bulky dialysis cartridges containing ≈2 m2 of 10 micrometer thick, tortuous-path membranes. Portable and wearable HD systems can improve outcomes for patients with end-stage renal disease by facilitating more frequent, longer dialysis at
Cécile Bienboire-Frosini et al.
International journal of molecular sciences, 21(4) (2020-02-23)
The major cat allergen Fel d 1 is a tetrameric glycoprotein of the secretoglobin superfamily. Structural aspects and allergenic properties of this protein have been investigated, but its physiological function remains unclear. Fel d 1 is assumed to bind lipids
Tony Velkov et al.
Cell chemical biology, 25(4), 380-391 (2018-02-06)
Resistance to the last-resort antibiotic colistin is now widespread and new therapeutics are urgently required. We report the first in toto chemical synthesis and pre-clinical evaluation of octapeptins, a class of lipopeptides structurally related to colistin. The octapeptin biosynthetic cluster consisted
Ashok Mohanty et al.
Journal of chromatography. A, 1128(1-2), 259-266 (2006-07-04)
Two vesicle-forming single-tailed amino acid derivatized surfactants sodium N-[4-n-dodecyloxybenzoyl]-L-leucinate (SDLL) and sodium N-[4-n-dodecyloxybenzoyl]-L-isoleucinate (SDLIL) have been synthesized and used as pseudo-stationary phase in micellar electrokinetic chromatography to evaluate the role of steric factor of amino acid headgroup and hydrophobic/hydrophilic interactions
Xiu-Li Liu et al.
Molecules (Basel, Switzerland), 18(2), 2183-2199 (2013-02-12)
Condensed tannins (CT) from purple prairie clover (PPC; Dalea purpurea Vent.) and sainfoin (SF; Onobrychis viciifolia) were assessed for anti-Escherichia coli activity by comparing their ability to react with proteins and liposome, cause cell aggregation, and alter outer membrane (OM)
Wei Hong et al.
ACS applied materials & interfaces, 10(13), 10688-10705 (2018-03-09)
Although nano-self-assemblies of hydrophobic-modified bacitracin A with poly(d,l-lactic- co-glycolic acid) (PLGA) (nano-BAPLGA) have demonstrated promising antibacterial activities, the application of nano-BAPLGA was severely compromised by low water solubility. In this study, a series of PEGylated PLGA copolymers were selected to
S Katti et al.
Insect molecular biology, 22(1), 31-40 (2012-11-06)
Many pheromones have very low water solubility, posing experimental difficulties for quantitative binding measurements. A new method is presented for determining thermodynamically valid dissociation constants for ligands binding to pheromone-binding proteins, using β-cyclodextrin as a solubilizer and transfer agent. The
William Kirk
Biophysical chemistry, 125(1), 13-23 (2006-09-16)
We continue our investigation of the photophysics of 1,8-anilinonaphthalenesulfonate in protein and solvent systems. In this report, we concentrate on the nature of the excited states as observed in UV spectra. We develop a fairly general formalism for handling the
Moh'd A Salameh et al.
The open biochemistry journal, 4, 22-28 (2010-04-03)
Thermosyntropha lipolytica DSM 11003, an anaerobic thermophilic lipolytic bacterium, produces the two alkalithermophilic lipases, LipA and LipB. Among all tested detergents, the two lipases were mostly affected by SDS when used at concentrations below its critical micelle concentration (CMC). In
Shu J Lam et al.
ACS applied materials & interfaces, 8(49), 33446-33456 (2016-12-15)
'Structurally nanoengineered antimicrobial peptide polymers' (SNAPPs), in the form of star-shaped peptide polymer nanoparticles, have been recently demonstrated as a new class of antimicrobial agents with superior in vitro and in vivo efficacy against Gram-negative pathogens, including multidrug-resistant species. Herein
Binbin Xu et al.
Scientific reports, 6, 39504-39504 (2016-12-22)
A series of fluorine-containing amphiphilic ABC triblock copolymers comprising hydrophilic poly(ethylene glycol) (PEG) and poly(methacrylic acid) (PMAA), and hydrophobic poly(p-(2-(4-biphenyl)perfluorocyclobutoxy)phenyl methacrylate) (PBPFCBPMA) segments were synthesized by successive atom transfer radical polymerization (ATRP). First, PEG-Br macroinitiators bearing one terminal ATRP initiating
Bo Ma et al.
Bio-protocol, 10(5), e3548-e3548 (2021-03-05)
The emergence and rapid spread of multidrug resistance in bacteria have led to the urgent need for novel antibacterial agents. Membrane permeabilization is the mechanism for many antibacterial molecules that are being developed against gram-negative bacteria. Thus, to determine the
Lingqia Su et al.
Bioresource technology, 196, 176-183 (2015-08-04)
The Pseudomonas putida arginine deiminase (ADI), a natural cytosolic enzyme, and Thermobifida fusca cutinase were co-expressed in Escherichia coli, and the optimized cutinase gene was used for increasing its expression level. 90.9% of the total ADI protein was released into
Christina Bamia et al.
European journal of epidemiology, 30(6), 473-483 (2015-03-20)
Recently, epidemiologists tend to focus on the association of health outcomes with combinations of exposures (composites), defined a-priori or a-posteriori. Such composites appear often in nutritional (dietary patterns) and genetic (genetic scores) epidemiology. The estimated associations, however, have not been
Beijun Liu et al.
Journal of peptide science : an official publication of the European Peptide Society, 23(11), 824-832 (2017-08-24)
Cationic antimicrobial peptides have attracted increasing attention as a novel class of antibiotics to treat infectious diseases caused by pathogenic bacteria. However, susceptibility to protease is a shortcoming in their development. Cyclization is one approach to increase the proteolytic resistance
Yawei Ning et al.
Food chemistry, 228, 533-540 (2017-03-21)
Phenyllactic acid (PLA), a phenolic acid phytochemical, is considered to be a promising candidate for use as a chemical preservative due to its broad antimicrobial activity. The antibacterial target of PLA has rarely been reported, thus investigations were performed to
Rita Ghosh et al.
Langmuir : the ACS journal of surfaces and colloids, 36(21), 5829-5838 (2020-05-12)
PEGylated vesicles are known to serve as blood-persistent drug-delivery systems (DDSs) with potential applications in intravenous drug administration. pH-responsive PEGylated vesicles are also among the most promising stimuli-responsive carriers for drug delivery and controlled release for cancer chemotherapy. Herein, we
R G Heendeniya et al.
Journal of agricultural and food chemistry, 67(17), 4793-4799 (2019-04-20)
The utilization of the nutrient potential of alfalfa ( Medicago sativa L.) cannot be maximized because of its rapidly degradable protein content in the rumen, leading to waste and various digestive disorders. This might be alleviated if protein-binding proanthocyanidins are
Khaled A Shaaban et al.
Journal of natural products, 70(10), 1545-1550 (2007-09-25)
The terrestrial Streptomyces sp. isolate GW6225 afforded julichrome Q 6 glucuronide ( 9), the first monomeric member of the julimycin-B complex, and additionally the julichromes Q 1.2 ( 7a), Q 1.5 ( 7b), and Q 3.5 ( 8), which were
Xiaoyan Ning et al.
International journal of molecular sciences, 19(2) (2018-02-01)
Glucose oxidase (GOD, EC.1.1.3.4) specifically catalyzes the reaction of β-d-glucose to gluconic acid and hydrogen peroxide in the presence of oxygen, which has become widely used in the food industry, gluconic acid production and the feed industry. However, the poor
Huili Qiao et al.
Cellular and molecular life sciences : CMLS, 68(10), 1799-1813 (2010-10-20)
To understand olfactory discrimination in Anopheles gambiae, we made six purified recombinant OBPs and investigated their ligand-binding properties. All OBPs were expressed in bacteria with additional production of OBP47 in the yeast Kluveromyces lactis. Ligand-binding experiments, performed with a diverse
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