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Josué Delgado et al.
Microorganisms, 6(3) (2018-07-18)
Aflatoxigenic molds can grow and produce aflatoxins on dry-fermented meat and cheese. The small, basic, cysteine-rich antifungal protein PgAFP displays a time-limited inhibitory ability against unwanted molds by increasing reactive oxygen species (ROS), which can lead to increased aflatoxin production.
Chao Zhong et al.
Microbial pathogenesis, 139, 103871-103871 (2019-11-17)
Antimicrobial peptides have recently attracted much attention due to their broad-spectrum antimicrobial activity, rapid microbial effects, and minimal tendency toward resistance development. In this study, a series of new C-C terminals and C-N terminals dimer peptides were designed and synthesized
Minju Seong et al.
Current microbiology, 74(6), 661-670 (2017-03-23)
The evolution of antibiotics-resistant bacteria is considered a major concern. To explore promising antibacterial materials and clarify their unknown mechanisms, the mode of action of silver nanoparticles (AgNPs) against Salmonella enterica serotype typhimurium was investigated. We investigated the effect of
Thanyaluck Siriyong et al.
BMC complementary and alternative medicine, 17(1), 405-405 (2017-08-16)
Holarrhena antidysenterica has been employed as an ethnobotanical plant for the treatment of dysentery, diarrhoea, fever, and bacterial infections. Biological activities of the principle compound, conessine including anti-diarrhoea and anti-plasmodial effects were documented. Our previous study reported potency of Holarrhena
Shigeki Nakamura et al.
PLoS pathogens, 7(1), e1001247-e1001247 (2011-01-22)
Non-typeable Haemophilus influenzae (NTHi), a common commensal of the human pharynx, is also an opportunistic pathogen if it becomes established in the lower respiratory tract (LRT). In comparison to colonizing isolates from the upper airway, LRT isolates, especially those associated
Peter Richter et al.
Antibiotics (Basel, Switzerland), 8(4) (2019-09-25)
Colistin (polymyxin E) is a membrane-destabilizing antibiotic used against Gram-negative bacteria. We have recently reported that the outer membrane prevents the uptake of antibacterial chlorophyllin into Gram-negative cells. In this study, we used sub-toxic concentrations of colistin to weaken this
Noushin Akhoundsadegh et al.
Antimicrobial agents and chemotherapy, 63(10) (2019-07-25)
Infections caused by drug-resistant Gram-negative bacilli are a severe global health threat, limiting effective drug choices for treatment. In this study, polymyxin analogs designed to have reduced nephrotoxicity, direct activity, and potentiating activity were assessed for inhibition and outer membrane
Alfredo Martínez et al.
Endocrinology, 147(7), 3457-3461 (2006-04-01)
Posttranslational processing of proadrenomedullin generates two biologically active peptides, adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP). Sequence comparison of homologous proadrenomedullin genes in vertebrate evolution shows a high degree of stability in the reading frame for AM, whereas PAMP
Advances in the structural studies of antibiotic potentiators against Escherichia coli.
Gifty A Blankson et al.
Bioorganic & medicinal chemistry, 27(15), 3254-3278 (2019-06-27)
Y N Gao et al.
Chemosphere, 174, 732-738 (2017-02-19)
It has been puzzling whether and how a plant could exert a strong allelopathic inhibition to the target organisms by releasing low concentrations of allelochemicals. Plant allelochemicals have been proposed to be released continuously, however, direct evidence from specific allelochemicals
Qing-Quan Ma et al.
Protein and peptide letters, 19(11), 1144-1148 (2012-05-17)
A novel α-helical antimicrobial peptide G6 rich in Val/Arg residues has been screened previously. In this study, we further evaluated the biochemical stability, interaction with whole bacteria, and in vivo therapeutic or prophylactic role of the peptide in Salmonella typhimurium-infected
G M Halliday et al.
Journal of immunological methods, 28(3-4), 381-390 (1979-01-01)
N-phenyl-1-naphthylamine (NPN) becomes fluorescent after binding to hydrophobic regions of cell membranes. Rat and mouse lymphoid cell suspensions stained with NPN showed changes in fluorescence emission 30 min after stimulation with mitogen or antigen, detected by microfluorimetry. Incubation of NPN-labelled
Cambria J Alpha et al.
Applied and environmental microbiology, 81(3), 1147-1156 (2014-12-03)
Muscodor albus belongs to a genus of endophytic fungi that inhibit and kill other fungi, bacteria, and insects through production of a complex mixture of volatile organic compounds (VOCs). This process of mycofumigation has found commercial application for control of
Rebecca M Harman et al.
Stem cell research & therapy, 8(1), 157-157 (2017-07-06)
The prevalence of chronic skin wounds in humans is high, and treatment is often complicated by the presence of pathogenic bacteria. Therefore, safe and innovative treatments to reduce the bacterial load in cutaneous wounds are needed. Mesenchymal stromal cells (MSC)
Hongyun Niu et al.
Journal of chromatography. A, 1172(2), 113-120 (2007-10-30)
As a novel nanomaterial, titanate nanotube has attracted considerable attention recently. However, most of the research work is focused on the preparation of this nanomaterial, and there is lack of information about its application in the fields of environmental monitoring
Determination of the critical micelle concentration of surfactants using the fluorescent probe N-phenyl-1-naphthylamine.
Bergbreiter DE and Pendergrass E.
The Journal of Organic Chemistry, 46(1), 219-220 (1981)
Liang Sun et al.
Journal of insect physiology, 116, 17-24 (2019-04-23)
Pheromone-binding proteins (PBPs) are considered to play critical roles in sex pheromone detection. Lepidopteran moths can be divided into two taxa, those that use Type-I sex pheromones, such as C10-C18 unsaturated aldehydes, alcohols and acetates, and those that use Type-II
Hui Jiang et al.
Journal of neuroscience methods, 261, 62-74 (2015-12-26)
Aversive olfactory classical conditioning has been the standard method to assess Drosophila learning and memory behavior for decades, yet training and testing are conducted manually under exceedingly labor-intensive conditions. To overcome this severe limitation, a fully automated, inexpensive system has
Self-assembling diphenylalanine peptide nanotubes selectively eradicate bacterial biofilm infection.
Simon L Porter et al.
Acta biomaterialia, 77, 96-105 (2018-07-22)
Biofilms present a major problem to industry and healthcare worldwide. Composed of a population of surface-attached microbial cells surrounded by a protective extracellular polysaccharide matrix, they are responsible for increased tolerance to antibiotics, treatment failure and a resulting rise in
Junqiu Xie et al.
Journal of peptide science : an official publication of the European Peptide Society, 21(7), 599-607 (2015-04-22)
The increased emergence of multidrug-resistant bacteria is perceived as a critical public health threat, creating an urgent need for the development of novel classes of antimicrobials. Cell-penetrating peptides that share common features with antimicrobial peptides have been found to have
Moh'd A Salameh et al.
The open biochemistry journal, 4, 22-28 (2010-04-03)
Thermosyntropha lipolytica DSM 11003, an anaerobic thermophilic lipolytic bacterium, produces the two alkalithermophilic lipases, LipA and LipB. Among all tested detergents, the two lipases were mostly affected by SDS when used at concentrations below its critical micelle concentration (CMC). In
Kayli Hill et al.
Advanced healthcare materials, 9(4), e1900750-e1900750 (2020-01-17)
Conventional hemodialysis (HD) uses floor-standing instruments and bulky dialysis cartridges containing ≈2 m2 of 10 micrometer thick, tortuous-path membranes. Portable and wearable HD systems can improve outcomes for patients with end-stage renal disease by facilitating more frequent, longer dialysis at
Lei Wang et al.
Veterinary microbiology, 243, 108634-108634 (2020-04-11)
Actinobacillus pleuropneumoniae is the causative agent of highly contagious and fatal respiratory infections, causing substantial economic losses to the global pig industry. Due to increased antibiotic resistance, there is an urgent need to find new antibiotic alternatives for treating A.
Silvia Spinelli et al.
Insect biochemistry and molecular biology, 42(1), 41-50 (2011-11-15)
Apis mellifera (Amel) relies on its olfactory system to detect and identify new-sources of floral food. The Odorant-Binding Proteins (OBPs) are the first proteins involved in odorant recognition and interaction, before activation of the olfactory receptors. The Amel genome possess
Daniel Pletzer et al.
PLoS pathogens, 14(6), e1007084-e1007084 (2018-06-22)
With the antibiotic development pipeline running dry, many fear that we might soon run out of treatment options. High-density infections are particularly difficult to treat due to their adaptive multidrug-resistance and currently there are no therapies that adequately address this
Mridula Dwivedi et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 144, 105211-105211 (2020-01-14)
Polysorbate is one of the most commonly employed non-ionic surfactant in protein containing biological formulations, whereby, it can stabilize these biomolecules under different stress conditions. Despite the fact that polysorbates are present in almost 70% of currently marketed parenteral biological
Xiu-Li Liu et al.
Molecules (Basel, Switzerland), 18(2), 2183-2199 (2013-02-12)
Condensed tannins (CT) from purple prairie clover (PPC; Dalea purpurea Vent.) and sainfoin (SF; Onobrychis viciifolia) were assessed for anti-Escherichia coli activity by comparing their ability to react with proteins and liposome, cause cell aggregation, and alter outer membrane (OM)
Tony Velkov et al.
Cell chemical biology, 25(4), 380-391 (2018-02-06)
Resistance to the last-resort antibiotic colistin is now widespread and new therapeutics are urgently required. We report the first in toto chemical synthesis and pre-clinical evaluation of octapeptins, a class of lipopeptides structurally related to colistin. The octapeptin biosynthetic cluster consisted
Cécile Bienboire-Frosini et al.
International journal of molecular sciences, 21(4) (2020-02-23)
The major cat allergen Fel d 1 is a tetrameric glycoprotein of the secretoglobin superfamily. Structural aspects and allergenic properties of this protein have been investigated, but its physiological function remains unclear. Fel d 1 is assumed to bind lipids
S Katti et al.
Insect molecular biology, 22(1), 31-40 (2012-11-06)
Many pheromones have very low water solubility, posing experimental difficulties for quantitative binding measurements. A new method is presented for determining thermodynamically valid dissociation constants for ligands binding to pheromone-binding proteins, using β-cyclodextrin as a solubilizer and transfer agent. The
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