104094

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Effect of lipidated gonadotropin-releasing hormone peptides on receptor mediated binding and uptake into prostate cancer cells in vitro.

Rachel Stephenson et al.

Nanomedicine : nanotechnology, biology, and medicine, 10(8), 1799-1808 (2014-07-12)

Gonadotropin-releasing hormone (GnRH) receptors are overexpressed on many cancer cells but not on primary cell lines. This study was designed to investigate the targeting ability and uptake of dendritic lipidated [Gln(1)]-GnRH peptide analogues on receptor-positive prostate cancer PC-3 cells relative

Collagen-mimetic peptide-modifiable hydrogels for articular cartilage regeneration.

Paresh A Parmar et al.

Biomaterials, 54, 213-225 (2015-04-25)

Regenerative medicine strategies for restoring articular cartilage face significant challenges to recreate the complex and dynamic biochemical and biomechanical functions of native tissues. As an approach to recapitulate the complexity of the extracellular matrix, collagen-mimetic proteins offer a modular template

Moessbauer spectra of some porphyrin complexes with pyridine, piperidine, and imidazole.

Epstein LM, et al.

Inorganic Chemistry, 6(9), 1720-1724 (1967)

RNA-Seq Based De Novo Transcriptome Assembly and Gene Discovery of Cistanche deserticola Fleshy Stem.

Yuli Li et al.

PloS one, 10(5), e0125722-e0125722 (2015-05-06)

Cistanche deserticola is a completely non-photosynthetic parasitic plant with great medicinal value and mainly distributed in desert of Northwest China. Its dried fleshy stem is a crucial tonic in traditional Chinese medicine with roles of mainly improving male sexual function

Integrating Phosphoproteomics and Bioinformatics to Study Brassinosteroid-Regulated Phosphorylation Dynamics in Arabidopsis.

Li-Ling Lin et al.

BMC genomics, 16, 533-533 (2015-07-19)

Protein phosphorylation regulated by plant hormone is involved in the coordination of fundamental plant development. Brassinosteroids (BRs), a group of phytohormones, regulated phosphorylation dynamics remains to be delineated in plants. In this study, we performed a mass spectrometry (MS)-based phosphoproteomics

Structural, nanomechanical, and computational characterization of D,L-cyclic peptide assemblies.

Daniel J Rubin et al.

ACS nano, 9(3), 3360-3368 (2015-03-12)

The rigid geometry and tunable chemistry of D,L-cyclic peptides makes them an intriguing building-block for the rational design of nano- and microscale hierarchically structured materials. Herein, we utilize a combination of electron microscopy, nanomechanical characterization including depth sensing-based bending experiments

Experimental and computational investigation of the effect of hydrophobicity on aggregation and osteoinductive potential of BMP-2-derived peptide in a hydrogel matrix.

Seyedsina Moeinzadeh et al.

Tissue engineering. Part A, 21(1-2), 134-146 (2014-07-23)

An attractive approach to reduce the undesired side effects of bone morphogenetic proteins (BMPs) in regenerative medicine is to use osteoinductive peptide sequences derived from BMPs. Although the structure and function of BMPs have been studied extensively, there is limited

Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors.

Guohua Zhao et al.

Bioorganic & medicinal chemistry letters, 23(6), 1622-1625 (2013-02-19)

Synthesis and structure-activity relationship of a series of substituted piperidinyl glycine 2-cyano-4,5-methano pyrroline DPP-IV inhibitors are described. Improvement of the inhibitory activity and chemical stability of this series of compounds was respectively achieved by the introduction of bulky groups at

Protease-degradable electrospun fibrous hydrogels.

Ryan J Wade et al.

Nature communications, 6, 6639-6639 (2015-03-24)

Electrospun nanofibres are promising in biomedical applications to replicate features of the natural extracellular matrix (ECM). However, nearly all electrospun scaffolds are either non-degradable or degrade hydrolytically, whereas natural ECM degrades proteolytically, often through matrix metalloproteinases. Here we synthesize reactive

Interaction of Yna1 and Yna2 Is Required for Nuclear Accumulation and Transcriptional Activation of the Nitrate Assimilation Pathway in the Yeast Hansenula polymorpha.

Lucia Silvestrini et al.

PloS one, 10(9), e0135416-e0135416 (2015-09-04)

A few yeasts, including Hansenula polymorpha are able to assimilate nitrate and use it as nitrogen source. The genes necessary for nitrate assimilation are organised in this organism as a cluster comprising those encoding nitrate reductase (YNR1), nitrite reductase (YNI1)

Coupling technique of self-ordered ring and phosphorimetry for the determination of alkaline phosphatase and diseases prediction.

Li Hong Zhang et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 97, 639-647 (2012-08-04)

Rhodamine S could emit strong and stable room temperature phosphorescence (RTP) on polyamide membrane (PAM) in the presence of heavy atom perturber Pb(2+). When Rhodamine S-piperidine solution was dropped on PAM, the red (Rhod.S)(n)-P-SOR (Rhod.S, (Rhod.S)(n), P and SOR refer

Design of thiolate rich metal binding sites within a peptidic framework.

Marek Łuczkowski et al.

Inorganic chemistry, 47(23), 10875-10888 (2008-10-31)

A de novo protein design strategy provides a powerful tool to elucidate how heavy metals interact with proteins.Cysteine derivatives of the TRI peptide family (Ac-G(LKALEEK)4G-NH2) have been shown to bind heavy metals in an unusual trigonal geometry. Our present objective

Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.

Erik Serrao et al.

Journal of medicinal chemistry, 56(6), 2311-2322 (2013-03-01)

On the basis of an initial molecular modeling study suggesting the favorable binding of the "privileged" fragment 8-hydroxyquinoline with HIV-1 integrase (IN) at the IN-lens epithelium-derived growth factor/p75 (LEDGF/p75) interface , we developed a set of modified 8-hydroxyquinoline fragments demonstrating

Design and synthesis of digitally encoded polymers that can be decoded and erased.

Raj Kumar Roy et al.

Nature communications, 6, 7237-7237 (2015-05-27)

Biopolymers such as DNA store information in their chains using controlled sequences of monomers. Here we describe a non-natural information-containing macromolecule that can store and retrieve digital information. Monodisperse sequence-encoded poly(alkoxyamine amide)s were synthesized using an iterative strategy employing two

Targeting of anti-citrullinated protein/peptide antibodies in rheumatoid arthritis using peptides mimicking endogenously citrullinated fibrinogen antigens.

Cátia Fernandes-Cerqueira et al.

Arthritis research & therapy, 17, 155-155 (2015-06-11)

We have previously identified endogenously citrullinated peptides derived from fibrinogen in rheumatoid arthritis (RA) synovial tissues. In this study, we have investigated the auto-antigenicity of four of those citrullinated peptides, and explored their feasibility to target anti-citrullinated protein/peptide antibodies (ACPA).

Short KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity.

Binu Jacob et al.

Journal of peptide science : an official publication of the European Peptide Society, 19(11), 700-707 (2013-10-10)

KR-12 (residues 18-29 of LL-37) was known to be the smallest peptide of human cathelicidin LL-37 possessing antimicrobial activity. In order to optimize α-helical short antimicrobial peptides having both antimicrobial and antiendotoxic activities without mammalian cell toxicity, we designed and

The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects.

Aase M Raddum et al.

Biochemical pharmacology, 95(1), 1-15 (2015-03-17)

The progression of aggressive cancer occurs via angiogenesis and metastasis makes these processes important targets for the development of anti-cancer agents. However, recent studies have raised the concern that selective inhibition of angiogenesis results in a switch towards increased tumour

De novo RNA sequencing and transcriptome analysis of Colletotrichum gloeosporioides ES026 reveal genes related to biosynthesis of huperzine A.

Guowei Zhang et al.

PloS one, 10(3), e0120809-e0120809 (2015-03-24)

Huperzine A is important in the treatment of Alzheimer's disease. There are major challenges for the mass production of huperzine A from plants due to the limited number of huperzine-A-producing plants, as well as the low content of huperzine A

Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs.

Shruti U Gandhy et al.

BMC cancer, 12, 564-564 (2012-12-01)

Curcumin inhibits growth of several cancer cell lines, and studies in this laboratory in bladder and pancreatic cancer cells show that curcumin downregulates specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and pro-oncogenic Sp-regulated genes. In this study, we

Bicyclic peptides conjugated to an albumin-binding tag diffuse efficiently into solid tumors.

Lisa Pollaro et al.

Molecular cancer therapeutics, 14(1), 151-161 (2014-11-09)

Monoclonal antibodies have long in vivo half-lives and reach high concentrations in tumors but cannot access all regions in the tissue, whereas smaller ligands such as peptides distribute better but are limited by low concentrations due to fast renal clearance.

Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels.

Jae H Park et al.

Journal of medicinal chemistry, 57(15), 6623-6631 (2014-07-16)

The aqueous solution structure of protoxin II (ProTx II) indicated that the toxin comprises a well-defined inhibitor cystine knot (ICK) backbone region and a flexible C-terminal tail region, similar to previously described NaSpTx III tarantula toxins. In the present study

Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor.

Daniel W Kung et al.

Bioorganic & medicinal chemistry letters, 22(13), 4281-4287 (2012-06-09)

The discovery of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor is described. The characterization and redressing of the issues associated with these compounds is detailed. An efficient three-step synthesis and a binding assay were relied upon as the primary

An Efficient Catalytic DNA that Cleaves L-RNA.

Kha Tram et al.

PloS one, 10(5), e0126402-e0126402 (2015-05-07)

Many DNAzymes have been isolated from synthetic DNA pools to cleave natural RNA (D-RNA) substrates and some have been utilized for the design of aptazyme biosensors for bioanalytical applications. Even though these biosensors perform well in simple sample matrices, they

Design and synthesis of (R)-1-arylsulfonylpiperidine-2-carboxamides as 11β-hydroxysteroid dehydrogenase type 1 inhibitors.

Guangxin Xia et al.

ChemMedChem, 8(4), 577-581 (2013-03-09)

R adamantly beats S: 11β-HSD1 is a target for treating metabolic syndrome. The R isomer 5 was selected as a starting point for optimization and SAR studies. Inhibitor 8 w emerged after several rounds of optimization, showing cross-species inhibition of

Unraveling the interplay of backbone rigidity and electron rich side-chains on electron transfer in peptides: the realization of tunable molecular wires.

John R Horsley et al.

Journal of the American Chemical Society, 136(35), 12479-12488 (2014-08-15)

Electrochemical studies are reported on a series of peptides constrained into either a 310-helix (1-6) or β-strand (7-9) conformation, with variable numbers of electron rich alkene containing side chains. Peptides (1 and 2) and (7 and 8) are further constrained

Novel N-amidinopiperidine-based proteasome inhibitor preserves dendritic cell functionality and rescues their Th1-polarizing capacity in Ramos-conditioned tumor environment.

Urban Švajger et al.

Cancer immunology, immunotherapy : CII, 64(1), 15-27 (2014-09-26)

The tumor microenvironment represents a burden that hampers the proper activation of immune cells, including the dendritic cells (DCs). It is, therefore, desired that the important characteristics of a given anticancer drug candidate be seen as consisting not solely of

Feasibility of label-free phosphoproteomics and application to base-line signaling of colorectal cancer cell lines.

Sander R Piersma et al.

Journal of proteomics, 127(Pt B), 247-258 (2015-04-07)

Robust phosphopeptide enrichment methods with minimal fractionation are required to profile signaling network analysis in cancer cell lines and tissues. We assessed performance of single-shot LC-MS/MS label-free phosphoproteomics using TiOx-based phosphopeptide enrichment and report phosphopeptide identification reproducibility (75.8%), depth of

Bioluminescent liquid light guide pad biosensor for indoor air toxicity monitoring.

Evgeni Eltzov et al.

Analytical chemistry, 87(7), 3655-3661 (2015-03-17)

Indoor air pollution became a recent concern found to be oftentimes worse than outdoor air quality. We developed a tool that is cheap and simple and enables continuous monitoring of air toxicity. It is a biosensor with both a nondisposable

Molecularly engineered self-assembling membranes for cell-mediated degradation.

Daniela S Ferreira et al.

Advanced healthcare materials, 4(4), 602-612 (2014-11-22)

The use of peptide engineering to develop self-assembling membranes that are responsive to cellular enzyme activities is reported. The membranes are obtained by combining hyaluronan (HA) and a rationally designed peptide amphiphile (PA) containing a proteolytic domain (GPQGIWGQ octapeptide) sensitive

Synthesis of lucifensin by native chemical ligation and characteristics of its isomer having different disulfide bridge pattern.

Stancho Stanchev et al.

Journal of peptide science : an official publication of the European Peptide Society, 20(9), 725-735 (2014-06-13)

The antimicrobial 40-amino-acid-peptide lucifensin was synthesized by native chemical ligation (NCL) using N-acylbenzimidazolinone (Nbz) as a linker group. NCL is a method in which a peptide bond between two discreet peptide chains is created. This method has been applied to

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