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Cristina Japu et al.
Biomacromolecules, 16(3), 868-879 (2015-01-27)
Biotechnologically accessible 1,4-butanediol and vegetal oil-based diethyl sebacate were copolymerized with bicyclic acetalized D-glucose derivatives (Glux) by polycondensation both in the melt at high temperature and in solution at mild temperature mediated by polymer-supported Candida antarctica lipase B (CALB). Two
Heenam Kwon et al.
Journal of biomedical materials research. Part A, 103(2), 534-544 (2014-04-23)
Cartilage tissue engineering has emerged as an attractive therapeutic option for repairing damaged cartilage tissue in the arthritic joint. High levels of proinflammatory cytokines present at arthritic joints can cause cartilage destruction and instability of the engineered cartilage tissue, and
Weibo Zhang et al.
Journal of biomedical materials research. Part A, 97(4), 414-422 (2011-04-13)
Silk scaffolds have been successfully used for a variety of tissue engineering applications due to their biocompatibility, diverse physical characteristics, and ability to support cell attachment and proliferation. Our prior characterization of 4-day postnatal rat tooth bud cells grown on
P Sun et al.
British journal of pharmacology, 172(22), 5390-5402 (2015-09-13)
Stroke and Alzheimer's disease (AD) are related pathologies in which the cerebrovascular system is involved. Plasma levels of semicarbazide-sensitive amine oxidase/vascular adhesion protein 1 (SSAO/VAP-1, also known as Primary Amine Oxidase -PrAO) are increased in both stroke and AD patients
Yizhou Zhou et al.
Methods in molecular biology (Clifton, N.J.), 849, 303-320 (2012-04-25)
Many bacteria can assemble functional amyloid fibers on their cell surface. The majority of bacterial amyloids contribute to biofilm or other community behaviors where cells interact with a surface or with another cell. Bacterial amyloids, like all functional amyloids, share
Asta Lučiūnaitė et al.
Journal of neurochemistry, 155(6), 650-661 (2019-12-25)
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder causing memory loss, language problems and behavioural disturbances. AD is associated with the accumulation of fibrillar amyloid-β (Aβ) and the formation of neurofibrillary tau tangles. Fibrillar Aβ itself represents a danger-associated
Yadong Liu et al.
Acta biomaterialia, 10(12), 5074-5080 (2014-09-10)
Blends of aniline pentamer-graft-gelatin (AP-g-GA) and poly(l-lactide) (PLLA) were electrospun to prepare uniform nanofibers as biomimetic scaffolds. The nanofibers exhibited good electroactivity, thermal stability and biodegradability. The biocompatibility of the nanofibers in vitro was evaluated by the adhesion and proliferation
Jessica Perkins et al.
Journal of biomedical materials research. Part A, 102(12), 4290-4300 (2014-02-06)
The surface modification of metallic biomaterials is of critical importance to enhance the biocompatibility of surgical implant materials and devices. This article investigates the use of a direct-write inkjet technique for multilayer coatings of a biodegradable polymer (polyester urethane urea
Yi-An Lin et al.
ACS nano, 8(12), 12690-12700 (2014-11-22)
Mixing of oppositely charged amphiphilic molecules (catanionic mixing) offers an attractive strategy to produce morphologies different from those formed by individual molecules. We report here on the use of catanionic mixing of anticancer drug amphiphiles to construct multiwalled nanotubes containing
Haiqiang Wu et al.
PloS one, 9(10), e109438-e109438 (2014-10-03)
Inhibition of β-amyloid (Aβ) aggregation is an attractive therapeutic and preventive strategy for the discovery of disease-modifying agents in Alzheimer's disease (AD). Phomopsis occulta is a new, salt-tolerant fungus isolated from mangrove Pongamia pinnata (L.) Pierre. We report here the
Diego Mastroeni et al.
ACS chemical neuroscience, 6(4), 588-598 (2015-02-11)
Alzheimer's disease is associated with metabolic deficits and reduced mitochondrial function, with the latter due to the effects of oligomeric amyloid beta peptide (AβO) on the respiratory chain. Recent evidence has demonstrated reduction of epigenetic markers, such as DNA methylation
Simona Zuppolini et al.
Materials science & engineering. C, Materials for biological applications, 108, 110385-110385 (2020-01-12)
The growing interest in the use of polysaccharides nanoparticles for biomedical applications is related to the recent progresses on the synthesis of cellulose-based polymers with the specific functionalities. In particular, cellulose graft copolymers are emerging as amphiphilic materials suitable to
Sönke Oswald et al.
Angewandte Chemie (International ed. in English), 58(15), 5080-5084 (2019-02-16)
1,1,1,3,3,3-hexafluoro-propan-2-ol aggregates preferentially into an achiral dimer of achiral monomers, but the trimer is found to prefer three metastable chiral monomer units arranged into a strained OH⋅⋅⋅O hydrogen-bonded ring, which is reinforced by secondary CH⋅⋅⋅FC interactions. This is shown by
Cheng-Hung Lee et al.
International journal of nanomedicine, 9, 4117-4133 (2014-09-11)
This work reports on the development of a biodegradable dual-drug-eluting stent with sequential-like and sustainable drug-release of anti-platelet acetylsalicylic acid and anti-smooth muscle cell (SMC) proliferative paclitaxel. To fabricate the biodegradable stents, poly-L-lactide strips are first cut from a solvent-casted
Tahir Ali et al.
Scientific reports, 5, 11708-11708 (2015-06-30)
The pathological hallmarks of Alzheimer's disease (AD) include amyloid beta (Aβ) accumulation, neurofibrillary tangle formation, synaptic dysfunction and neuronal loss. In this study, we investigated the neuroprotection of novel osmotin, a plant protein extracted from Nicotiana tabacum that has been
Dustin C Ernst et al.
Journal of bacteriology, 197(8), 1368-1377 (2015-02-04)
Coenzyme A (CoA) is a ubiquitous coenzyme involved in fundamental metabolic processes. CoA is synthesized from pantothenic acid by a pathway that is largely conserved among bacteria and eukaryotes and consists of five enzymatic steps. While higher organisms, including humans
In vivo evaluation of electrospun polycaprolactone graft for anterior cruciate ligament engineering.
Frank A Petrigliano et al.
Tissue engineering. Part A, 21(7-8), 1228-1236 (2014-11-22)
The anterior cruciate ligament (ACL) is critical for the structural stability of the knee and its injury often requires surgical intervention. Because current reconstruction methods using autograft or allograft tissue suffer from donor-site morbidity and limited supply, there has been
K Halverson et al.
Biochemistry, 29(11), 2639-2644 (1990-03-20)
The amyloid beta-protein (1-42) is a major constituent of the abnormal extracellular amyloid plaque that characterizes the brains of victims of Alzheimer's disease. Two peptides, with sequences derived from the previously unexplored C-terminal region of the beta-protein, beta 26-33 (H2N-SNKGAIIG-CO2H)
Aditya Pandey et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 92(4), 269-278 (2014-06-20)
G-protein coupled receptors (GPCRs) are inherently dynamic membrane protein modulators of various important cellular signaling cascades. The apelin receptor (AR or APJ) is a class A GPCR involved in numerous physiological processes, implicated in angiogenesis during tumour formation and as
Buyun Chen et al.
Journal of chromatography. A, 1288, 73-81 (2013-03-27)
LC-MS based assays are a promising approach for the bioanalysis of oligonucleotide therapeutics due to their selectivity and structure identification capabilities. However, the lack of sensitivity and complicated sample preparation procedures remain a barrier for application of LC-MS based assays
Yung-Heng Hsu et al.
International journal of nanomedicine, 9, 4347-4355 (2014-09-24)
We developed biodegradable drug-eluting nanofiber-enveloped implants that provided sustained release of vancomycin and ceftazidime. To prepare the biodegradable nanofibrous membranes, poly(D,L)-lactide-co-glycolide and the antibiotics were first dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol. They were electrospun into biodegradable drug-eluting membranes, which were then enveloped
Chunxiu Huang et al.
Biosensors & bioelectronics, 63, 478-482 (2014-08-19)
The electrogenerated chemiluminescence (ECL) behavior of the bioinspired peptide nanovesicles (PNVs) was reported for the first time. The PNVs modified glassy carbon electrodes have shown a stable and efficient cathodic ECL signal with K2S2O8 as coreactant in aqueous solution. The
Iliya Lefterov et al.
Neurobiology of disease, 82, 132-140 (2015-06-15)
We have recently demonstrated that short term bexarotene treatment of APP/PS1 mice significantly improves their cognitive performance. While there were no changes in plaque load, or insoluble Aβ levels in brain, biochemical analysis strongly suggested improved clearance of soluble Aβ
Pierre-Alexis Mouthuy et al.
Biotechnology letters, 37(5), 1107-1116 (2015-01-01)
To demonstrate that portable electrospinning devices can spin a wide range of polymers into submicron fibres and provide a mesh quality comparable to those produced with benchtop machines. We have designed a small, battery-operated electrospinning apparatus which enables control over
Wankun Zhu et al.
Acta biomaterialia, 10(7), 3018-3028 (2014-04-08)
Vasospasm is a common post-operative complication after vascular anastomosis. Currently, the main treatment is a local injection of antispasmodic drugs. However, this method has a high rate of relapse and is subject to a large degree of individual variation, and
Sanjai Kumar Pachahara et al.
Journal of peptide science : an official publication of the European Peptide Society, 18(4), 233-241 (2012-01-19)
Deposition of insoluble fibrillar aggregates of β-amyloid (Aβ) peptides in the brain is a hallmark of Alzheimer's disease. Apart from forming fibrils, these peptides also exist as soluble aggregates. Fibrillar and a variety of nonfibrillar aggregates of Aβ have also
Lingzhi Gong
Rapid communications in mass spectrometry : RCM, 29(24), 2402-2410 (2015-11-14)
Ion-pair reversed-phase liquid chromatography/electrospray ionization mass spectrometry (IP-RP-LC/ESI-MS) has been widely used for the quality control of oligonucleotides. However, researchers are still looking to improve mobile phase systems for IP-RP-LC/ESI-MS analysis of oligonucleotides. This study compared the performance of six
Karin Kipper et al.
Journal of chromatography. A, 1218(45), 8175-8180 (2011-10-05)
Two fluoroalcohols--1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) and 1,1,1,3,3,3-hexafluoro-2-methyl-2-propanol (HFTB)--were evaluated as volatile buffer acids in basic mobile phases for LC-ESI-MS determination of acidic and basic compounds. HFIP and HFTB as acidic buffer components offer interesting possibilities to adjust retention behavior of different analytes
Casper Hyttel Clausen et al.
Scanning, 33(4), 201-207 (2011-04-21)
In this report electrostatic force microscopy (EFM) is used to study different peptide self-assembled structures such as tubes and particles. It is shown that not only geometrical information can be obtained using EFM, but also information about the composition of
Dillip Kumar Bishi et al.
Journal of materials science. Materials in medicine, 25(11), 2579-2589 (2014-07-12)
Liver tissue engineering using polymeric nanofibrous scaffold and stem cells holds great promises for treating end-stage liver failures. The aim of this study was to evaluate hepatic trans-differentiation potential of human mesenchymal stem cells (hMSCs) on a biomagnetic electrospun nanofibrous
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