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Yosuke Doi et al.
Cancer science, 101(6), 1529-1535 (2010-04-07)
Vascular endothelial growth factor receptors (VEGFRs) are mainly expressed by endothelial cells, but they are also expressed by some cancer cells, including pancreatic cancer. The objective of this study was to evaluate the significance of VEGFRs expression in pancreatic cancer
Prognostic value of immunohistochemical staining of p53, bcl-2, and Ki-67 in small cell lung cancer.
Kwang Hyun Paik et al.
Journal of Korean medical science, 21(1), 35-39 (2006-02-16)
Small cell lung cancer (SCLC) is one of the most fatal cancers in humans and many factors are known to be related to its poor prognosis. Immunohistochemical (IHC) stainings were done on SCLC specimens in order to investigate the prognostic
K Cope et al.
Gastroenterology, 119(5), 1340-1347 (2000-10-31)
Similarities in the hepatic responses to obesity and ethanol exposure suggest that these conditions evoke common pathogenic mechanisms. Thus, it is possible that ethanol exposure is increased in obesity. Given that intestinal bacteria can produce ethanol, the aim of this
F I V Errera et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 39(7), 883-888 (2006-07-25)
Diabetes mellitus (DM) is a highly prevalent complex genetic disorder. There has been a worldwide effort in the identification of susceptibility genes for DM and its complications, and the 5-10-methylenetetrahydrofolate reductase (MTHFR) and apolipoprotein-E (APOE) genes have been considered good
A Shtauvere-Brameus et al.
Annals of the New York Academy of Sciences, 958, 357-361 (2002-05-22)
Insulin-dependent diabetes mellitus (IDDM) is one of the most common chronic diseases. It is an autoimmune disease. Genes contributing the most for development of IDDM are located on chromosome 6p21.3 in the region called the major histocompatibility complex (MHC). HLA-DQ8/DR4
Jianming Xiang et al.
Neuroscience letters, 396(3), 225-229 (2005-12-21)
The aims of the current study were (1) to quantify the role of PEPT2 in the uptake of glycylsarcosine (GlySar) in cultured neonatal astrocytes and (2) to examine GlySar transport and PEPT2 expression in two glioma cell lines. The uptake
Hidefumi Kita et al.
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 17(5), 454-460 (2011-09-02)
We examined the influence of inflammatory cytokine levels on postoperative early recurrence in patients who underwent curative lung cancer surgery. In 107 patients who underwent curative pulmonary resections for non-small cell lung cancer (NSCLC) from November 2007 to June 2008
Noriko Matsuyama et al.
Hepatology research : the official journal of the Japan Society of Hepatology, 25(3), 221-225 (2003-04-17)
We studied a possible correlation between the dinucleotide microsatellite polymorphism of the interferon alpha/beta receptor-1 gene (IFNAR1) and responsiveness of hepatitis C patients to interferon therapy. The length of GT-repeat (n of (GT)(n)) in the IFNAR1 promoter was determined in
Pierluigi Cocco et al.
The Journal of endocrinology, 182(3), 391-397 (2004-09-08)
To explore endocrine effects in relation to para,para'-dichloro-diphenyl-dichloro ethylene (p,p'-DDE) body burden and past occupational exposure to its precursor dichloro-diphenyl-trichloro ethane (DDT), we assayed serum sex hormones, including serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), 17beta-estradiol (E2), testosterone and sex
I N Ruchkina et al.
Terapevticheskii arkhiv, 85(2), 21-26 (2013-05-09)
To estimate the incidence of secondary lactase deficiency (SLD) in patients with postinfectious irritable bowel syndrome (PIBS) and the value of the small bowel microflora in its development and to elaborate treatment options for SLD. One hundred and thirty-eight patients
Mohsen Eslami et al.
Theriogenology, 84(3), 437-445 (2015-05-09)
Postpartum endometritis is considered as one of the diseases that lead to a potential profit reduction in dairy cows. The aims of the present study were to promote follicle growth by a previously used controlled internal drug release (CIDR) device
Niclas Franck et al.
Blood pressure, 21(2), 122-127 (2011-10-25)
The interaction of the PPARγ Pro12Ala polymorphism with diabetes and cardiovascular risk is controversial. We studied 173 women and 309 men in the observational CARDIPP trial in which determination of left ventricular mass, carotid intima-media thickness (IMT) and pulse wave
Michelangelo Pascale et al.
Journal of food protection, 74(10), 1700-1707 (2011-10-19)
The effect of processing on mycotoxin content in milling fractions has been investigated in 10 samples of durum wheat contaminated with T-2 and HT-2 toxins at levels ranging from 97 to 5,954 μg/kg (sum of T-2 and HT-2 toxins). Either
Michael F Berger et al.
Nature, 485(7399), 502-506 (2012-05-25)
Melanoma is notable for its metastatic propensity, lethality in the advanced setting and association with ultraviolet exposure early in life. To obtain a comprehensive genomic view of melanoma in humans, we sequenced the genomes of 25 metastatic melanomas and matched
Maho Ukaji et al.
Drug metabolism and pharmacokinetics, 22(6), 462-467 (2007-12-27)
The vitamin D receptor (VDR) is a transcriptional factor responsive to 1alpha,25-dihydroxyvitamin D(3) and lithocholic acid, and induces expression of drug metabolizing enzymes CYP3A4, CYP2B6 and CYP2C9. In this study, the promoter regions, 14 exons (including 6 exon 1's) and
Michael S Korenfeld et al.
Journal of cataract and refractive surgery, 35(1), 26-34 (2008-12-23)
To assess the efficacy and safety of difluprednate ophthalmic emulsion 0.05% (Durezol) 2 or 4 times a day compared with those of a placebo in the treatment of inflammation and pain associated with ocular surgery. Twenty-six clinics in the United
Benjamin Speich et al.
The Lancet. Infectious diseases, 15(3), 277-284 (2015-01-16)
Existing anthelmintic drugs (eg, albendazole and mebendazole) have low efficacy against the intestinal nematode species Trichuris trichiura and the drug pipeline is exhausted. We aimed to investigate the strategy of combination chemotherapy with existing drugs to establish whether their efficacy
Magdalena Wieczorek et al.
Food and environmental virology, 7(3), 224-231 (2015-04-12)
The aim of this study was to apply environmental surveillance to evaluate circulation of non-polio enteroviruses (NPEVs) in sewage in Poland. Samples of raw sewage were collected in 14 sewage disposal systems from January to December, 2011. Sewage samples were
B Babbette D LaMarca et al.
Hypertension (Dallas, Tex. : 1979), 46(4), 1022-1025 (2005-09-08)
Inflammatory cytokines such as tumor necrosis factor (TNF)-alpha are elevated in preeclamptic women and are thought to be an important link between placental ischemia and endothelial dysfunction. The purpose of this study was to determine the role of TNF in
Jae-Hoon Kim et al.
JAMA, 287(13), 1671-1679 (2002-04-03)
Development of new biomarkers for ovarian cancer is needed for early detection and disease monitoring. Analyses involving complementary DNA (cDNA) microarray data can be used to identify up-regulated genes in cancer cells, whose products may then be further validated as
Kathryn L Pepple et al.
Investigative ophthalmology & visual science, 59(6), 2504-2511 (2018-05-31)
To compare lymphocyte populations present within inflamed eyes in two rat models of autoimmune uveitis. Experimental autoimmune uveitis (EAU) and primed mycobacterial uveitis (PMU) were initiated in Lewis rats. Aqueous and vitreous were collected at peak inflammation (PMU at day
B Filipe et al.
Clinical genetics, 76(3), 242-255 (2009-10-02)
Patients presenting familial adenomatous polyposis (FAP), attenuated familial adenomatous polyposis (AFAP) or multiple colorectal adenomas (MCRAs) phenotype are clinically difficult to distinguish. We aimed to genetically characterize 107 clinically well-characterized patients with FAP-like phenotype, and stratified according to the recent
Zhao-Hui Yin et al.
World journal of gastroenterology, 11(8), 1232-1236 (2005-03-09)
To investigate the expression of tumor necrosis factor-alpha (TNF-alpha) and vascular endothelial growth factor (VEGF) in the development of esophageal varices in portal hypertensive rats. Thirty male Sprague-Dawley (SD) rats in the model group in which a two-stage ligation of
Jinwei Du et al.
Journal of virological methods, 287, 114009-114009 (2020-11-06)
Serology tests for detecting the antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can identify previous infection and help to confirm the presence of current infection. The aim of this study was to evaluate the performances of a newly
Guo-Rui Ruan et al.
Annals of hematology, 88(2), 159-166 (2008-08-30)
Recently, mutations in the nucleophosmin (NPM1) gene were detected in 50-60% of adult acute myelogenous leukemia (AML) patients, mainly with a normal karyotype. In this study, we detected typical NPM1 mutations (types A, B, D) in untreated Chinese AML patients
Yingzi Lin et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 26(10), 839-845 (2003-11-19)
We have previously reported that urotensin II acts on the central nervous system to increase blood pressure in normotensive rats. In the present study, we have determined the central cardiovascular action of urotensin II in spontaneously hypertensive rats (SHR). Intracerebroventricular
Ranjana Verma et al.
Journal of human genetics, 50(12), 635-640 (2005-10-11)
Chromosome 22q11-13 is one of the most consistent linkage regions for schizophrenia (SCZ) and bipolar disorder (BPAD). The SYNGR1 gene, which is associated with presynaptic vesicles in neuronal cells, is located on 22q13.1. We have previously identified a novel nonsense
Philippa J Talmud et al.
Arteriosclerosis, thrombosis, and vascular biology, 23(4), 644-649 (2003-04-15)
Alpha1-Antitrypsin (AAT) protects elastic tissue and may play a role in atherogenesis. The association of atherosclerosis progression with common AAT variants was considered in 2 clinical trials. We examined the association of AAT V213A, S and Z deficiency alleles, and
Taisuke Enoki et al.
Journal of applied physiology (Bethesda, Md. : 1985), 94(6), 2433-2438 (2003-03-04)
We compared the changes in monocarboxylate transporter 1 (MCT1) and 4 (MCT4) proteins in heart and skeletal muscles in sedentary control and streptozotocin (STZ)-induced diabetic rats (3 wk) and in trained (3 wk) control and STZ-induced diabetic animals. In nondiabetic
Rabia Hussain et al.
Journal of clinical immunology, 31(5), 913-923 (2011-07-15)
Dynamic cytokine profiles from endogenously activated T cells in transit from lymph node to the infected sites via the blood compartment after recent exposure to Mycobacterium tuberculosis may differentiate disease progressors from non-disease progressors in a BCG-vaccinated population. Household contacts
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