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关键词:'108-20-3'
显示 1-30 共 115 条结果 关于 "108-20-3" 范围 论文
Ken-ichi Kozaki et al.
Cancer science, 97(12), 1351-1358 (2006-10-21)
Phosphatidylinositol 3-kinases (PI3K) are a group of heterodimeric lipid kinases that regulate many cellular processes. Gene amplification and somatic mutations mainly within the helical (exon 9) and kinase (exon 20) domains of PIK3CA, which encode the 110-kDa catalytic subunit of
Darina Konstantinova et al.
DNA and cell biology, 29(2), 65-70 (2009-10-21)
The molecular basis of endometrial cancer (EC), a common gynecologic malignancy, often includes mutational activation of the PIK3CA and KRAS genes. We aimed to determine the distribution of mutations in the two genes depending on patient clinocopathological characteristics. We sequenced
S Tajima et al.
The Journal of investigative dermatology, 82(3), 265-269 (1984-03-01)
Over 20 kilobase pairs of the human pro alpha 2(I) collagen gene have been isolated and characterized by restriction endonuclease mapping, cell-free translation of hybrid-selected RNA, and DNA sequence analysis. We have sequenced an exon and determined its length to
J F Clémence et al.
Bioconjugate chemistry, 6(4), 411-417 (1995-07-01)
To attain light-dependent functionalization of biocompatible materials, a photolabel-derivatized, bioactive laminin fragment has been synthesized, chemically characterized, and photoimmobilized. Covalent high-resolution patterning of the laminin fragment CDPGYIGSR to hydroxylated fluorinated ethylene propylene (FEP-OH), poly(vinyl alcohol), and glycophase glass has been
Eun M Je et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 120(8), 635-639 (2012-07-12)
Recent studies have revealed several recurrent mutations in oncogenes that could not only be underlying mechanisms of tumorigenesis, but also be potential targets for cancer therapies. Compared to carcinomas, genetic alterations of sarcomas are relatively unknown. To see whether recurrent
Alternative promoter usage and tissue specific expression of the mouse somatostatin receptor 2 gene.
J Kraus et al.
FEBS letters, 428(3), 165-170 (1998-07-08)
We have cloned the 5' upstream regulatory region of the mouse somatostatin receptor 2 gene. Its genomic organization is novel among all somatostatin receptor genes. It contains two previously unrecognized exons, separated by introns larger than 25 kb, and three
Steven S Yu et al.
Clinical genitourinary cancer, 15(6), 742-749 (2017-07-03)
AEZS-108 (zoptarelin doxorubicin) is a cytotoxic hybrid molecule consisting of doxorubicin covalently coupled with a luteinizing hormone-releasing hormone (LHRH) analogue, which selectively targets doxorubicin to tumor cells expressing LHRH receptors. We report the clinical efficacy of AEZS-108 in a phase
C M Fournier et al.
Blood, 89(12), 4584-4590 (1997-06-15)
An alpha-spectrin variant with increased susceptibility to tryptic digestion, alpha(II/47), was previously observed in a child with severe, recessively inherited, poikilocytic anemia. The molecular basis of this variant, spectrin St Claude, has now been identified as a splicing mutation of
Hua Li et al.
Experimental and molecular pathology, 88(1), 150-155 (2009-10-13)
Somatic mutations of PIK3CA are found in 20% to 40% of invasive breast cancers. To investigate the frequency of PIK3CA mutations in the intraductal proliferative lesions of the breast, which are precursor lesions for invasive carcinoma, we analyzed 125 intraductal
Qinglong Li et al.
Journal of experimental & clinical cancer research : CR, 28, 65-65 (2009-05-19)
An increasing number of studies have shown that ERK and PI3-K/AKT signaling pathways are involved in various human cancers including hepatocellular carcinoma and cholangiocarcinoma. However, few studies have examined gallbladder cancer specimens, and little is known about the clinical and
J W Furbee et al.
Journal of lipid research, 42(10), 1626-1635 (2001-10-09)
We have previously identified a single amino acid mutation (hE149A) in human LCAT that increases its in vitro reactivity with phosphatidylcholine species containing sn-2 arachidonate (Wang et al. 1997. J. Biol. Chem. 272: 280-286). The purpose of the present study
Paulo J C Anjos et al.
Zeitschrift fur Naturforschung. C, Journal of biosciences, 68(5-6), 181-190 (2013-08-09)
Linalool is a monoterpene alcohol and constituent of several Brazilian aromatic medicinal plants, popularly used against hypertension. Cardiovascular effects induced by linalool were evaluated. In normotensive rats, (+/-)-linalool [1, 5, 10, and 20 mg/kg body weight (BW); intravenous (i.v.)]-induced hypotension
Pietro Pepe et al.
Urologia internationalis, 89(2), 143-147 (2012-08-08)
To evaluate prostate cancer gene 3 (PCA3) score accuracy in preoperative staging of cases of single microfocus of prostate cancer (PCa; less than 5% with Gleason score ≤6) diagnosed after repeat saturation biopsy (median 30 cores). From January 2009 to
Shuju Wang et al.
Se pu = Chinese journal of chromatography, 25(2), 226-229 (2007-06-22)
A method for the simultaneous determination of captan and folpet pesticide residues in apples was developed by solid-phase extraction and high performance liquid chromatography. The sample was extracted with acetonitrile and cleaned-up by a mixture of homemade sorbent and silica
Marta Piatkowska et al.
Food chemistry, 197(Pt A), 571-580 (2015-12-01)
A multiclass method was developed for the simultaneous determination of 120 analytes in fresh eggs. The method covers the analytes from the groups of tetracyclines (6), fluoroquinolones (11), sulphonamides (17), nitroimidazoles (9), amphenicols (2), cephalosporins (7), penicillins (8), macrolides (8)
Y Murakami et al.
The Journal of veterinary medical science, 62(7), 743-750 (2000-08-17)
The involvement of cyclin A, cyclin D1 and p53 proteins in canine and feline tumorigenesis was analyzed immunohistochemically. In the present study, a total of 176 cases were examined, among which there were 108 canine cases (75 mammary lesions, 16
Hai-Long Xie et al.
World journal of gastroenterology, 10(8), 1125-1131 (2004-04-08)
To investigate the relationship between expression of p21(WAF1) and p53 gene, and to evaluate the deletion and polymorphism of p21(WAF1) gene in gastric carcinoma (GC). Expression of p21 and p53 proteins, and deletion and polymorphism of p21 gene in GC
D Nicholas Bateman et al.
Lancet (London, England), 383(9918), 697-704 (2013-12-03)
Paracetamol poisoning is common worldwide. It is treated with intravenous acetylcysteine, but the standard regimen is complex and associated with frequent adverse effects related to concentration, which can cause treatment interruption. We aimed to ascertain whether adverse effects could be
Celina Göttel et al.
International journal of molecular sciences, 21(18) (2020-09-25)
Phosphodiesterases (PDEs) are essential enzymes for the regulation of pathways mediated by cyclic adenosine monophosphate (cAMP). Secondary plant compounds like anthocyanins (ACs) can inhibit PDE activity and, consequently, may be beneficial for lipid metabolism. This study investigated 18 AC-rich juice
Laura E Dichtel et al.
The Journal of clinical endocrinology and metabolism, 99(12), 4712-4719 (2014-09-12)
Obesity is associated with diminished GH secretion, which may result in the overdiagnosis of adult GH deficiency (GHD) in overweight/obese pituitary patients. However, there are no body mass index (BMI)-specific peak GH cutoffs for the glucagon stimulation test (GST), the
W R Sperr et al.
Blood, 98(7), 2200-2209 (2001-09-25)
alpha- and beta-tryptase genes encode serine proteases that are abundantly expressed by mast cells. Under physiologic conditions other myeloid cells are virtually tryptase negative. However, tryptases are also expressed in several myeloid leukemia cell lines. In this study, serum total
Tomotada Iwamoto et al.
PloS one, 14(2), e0212798-e0212798 (2019-03-01)
Automated online software tools that analyse whole genome sequencing (WGS) data without the need for bioinformatics expertise can motivate the implementation of WGS-based molecular drug susceptibility testing (DST) in routine diagnostic settings for tuberculosis (TB). Pyrazinamide (PZA) is a key
W R Sperr et al.
Blood, 98(7), 2200-2209 (2001-09-25)
alpha- and beta-tryptase genes encode serine proteases that are abundantly expressed by mast cells. Under physiologic conditions other myeloid cells are virtually tryptase negative. However, tryptases are also expressed in several myeloid leukemia cell lines. In this study, serum total
Barbara Riond et al.
BMC veterinary research, 11, 183-183 (2015-08-08)
In vitro platelet aggregation in feline blood samples is a well-known phenomenon in veterinary clinical laboratories resulting in high numbers of pseudothrombocytopenia. Several attempts have been made to prevent or dissolve platelet aggregates in feline blood samples and to increase
Yong J Lee et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 10(6), 1894-1900 (2004-03-26)
We have previously observed that glucose deprivation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptotic death as well as caspase activation (caspase-3, -9, and -8) in human prostate adenocarcinoma DU-145 cells. In this study, we used caspase-3-deficient MCF-7 breast cancer
Claudia de O G Mendonça et al.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 13(1), 39-46 (2003-02-04)
To investigate the oxalate intake and the effect of an oxalate load on urinary oxalate excretion in calcium stone-forming (CSF) patients. Prospective study. University-affiliated outpatient Renal Lithiasis Unit. Seventy (70) CSF and 41 healthy subjects (HS) collected a 24-hour urine
Juan Qin et al.
Biomedical chromatography : BMC, 29(2), 261-267 (2014-06-14)
A simple, specific and sensitive LC-MS/MS method was developed and validated for the determination of mesalazine in beagle dog plasma. The plasma samples were prepared by protein precipitation, then the separation of the analyte was achieved on a Waters Spherisorb
V Vasiliou et al.
Pharmacogenetics, 4(6), 341-348 (1994-12-01)
We have cloned and sequenced the mouse NMO1 cDNA, which encodes the NAD(P)H:menadione oxidoreductase [also called NAD(P)H:(quinone acceptor) oxidoreductase; quinone reductase; azo dye reductase; DT diaphorase; EC 1.6.99.2]. The cDNA is 1528 bp in length excluding the poly(A+) tail, and
Robert E Nelson et al.
Clinical chemistry, 50(2), 373-384 (2003-12-06)
Estradiol (E2) and estrone (E1) measurements form an integral part of the assessment of female reproductive function and have expanding roles in other fields. However, many E1 and E2 immunoassays have limited functional sensitivity, suffer from cross-reactivity, and display poor
T Furuya et al.
Clinical and experimental rheumatology, 26(5), 918-921 (2008-11-27)
Our goal was to evaluate the associations of antibodies (Abs) to glucose-6-phosphate isomerase (GPI) with Abs to cyclic citrullinated peptide (CCP) and HLA-DRB1 genotypes in Japanese patients with early rheumatoid arthritis (RA). One hundred and eight patients with early RA
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