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D Nicholas Bateman et al.
Lancet (London, England), 383(9918), 697-704 (2013-12-03)
Paracetamol poisoning is common worldwide. It is treated with intravenous acetylcysteine, but the standard regimen is complex and associated with frequent adverse effects related to concentration, which can cause treatment interruption. We aimed to ascertain whether adverse effects could be
K Nikkilä et al.
Hepatology (Baltimore, Md.), 13(4), 663-669 (1991-04-01)
Serum levels of cholesterol precursors (squalene, delta 8-cholestanol, desmosterol and lathosterol), plant sterols (campesterol and sitosterol), cholestanol and cholestanol/noncholesterol sterol ratios were related to liver damage and liver transplantation indications in healthy controls (n = 26) and in 31 patients
Sung P Park et al.
Clinical & experimental ophthalmology, 36(9), 831-835 (2009-03-13)
To investigate sequential changes of aqueous vascular endothelial growth factor (VEGF) and interleukin (IL)-6 in macular oedema secondary to branch retinal vein occlusion after single intravitreal injection of triamcinolone acetonide (IVTA). We recruited 10 healthy controls and 30 patients at
Agustin Castiella et al.
Annals of hepatology, 14(3), 333-339 (2015-04-13)
There are limited data on clinical and phenotypic characteristics of outpatients referred for hyperferritinemia (HF). To determine the causes of HF in outpatients referred to a secondary hospital. A prospective study of 132 consecutive patients with HF (> 200 μg/L
A Georgopoulos et al.
The Journal of clinical endocrinology and metabolism, 85(9), 3155-3160 (2000-09-22)
Patients with type 2 diabetes are frequently dyslipidemic or hypertriglyceridemic. To assess whether increased intestinal triglyceride input leads to elevated fasting and postprandial triglycerides in type 2 diabetes, we used the codon 54 polymorphism of the fatty acid-binding protein 2
P F Kruse et al.
The Journal of cell biology, 42(1), 113-121 (1969-07-01)
Cell types in addition to those previously described (Kruse et al. 1963. J. Nat. Cancer Inst. 31:109; Kruse and Miedema. 1965. J. Cell Biol. 27:273) were found to form multiple-layered cultures by perfusion-culture technique. Dense populations containing 43 x 10(6)
Kenneth V I Rolston et al.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 22(1), 7-14 (2013-08-27)
The goal of this study was to describe the outcomes associated with daptomycin treatment of documented gram-positive infections in patients with neutropenia. All patients with neutropenia (≤500 cells/m(3)) and at least one documented gram-positive culture from 2006-2009 were identified from
Jing-Jie Yu et al.
Journal of clinical psychopharmacology, 35(4), 406-410 (2015-06-13)
Major depressive disorder is a devastating mental illness leading to a lifetime prevalence of higher than 16% on individuals. The treatment delay and inevitable adverse effects are major limitations of current depression interventions. Emerging evidence indicates that curcumin produced significant
Jin Yang et al.
The Journal of urology, 184(1), 336-343 (2010-05-22)
Varied XPC genetics are related to bladder cancer susceptibility. We determined whether decreased XPC expression influences bladder cancer malignancy and clinical outcome. Changes in XPC and p53 expression were detected by immunochemistry in 108 bladder cancers, including 29 papillary neoplasms
Angela García et al.
Anatomical record (Hoboken, N.J. : 2007), 295(5), 776-785 (2012-02-23)
This study sought to chart the ontogenesis of the goat rumen by histomorphometric examination, scanning electron microscopy and immunohistochemical analysis. A total of 140 goat embryos and fetuses were used, from the first stage of prenatal life until birth. The
G T Griffing et al.
Hypertension (Dallas, Tex. : 1979), 7(2), 178-181 (1985-03-01)
19-Nor-deoxycorticosterone (19-nor-DOC) is a human mineralocorticoid. The regulation of its secretion is poorly understood, as renin angiotensin II (ANG II) stimulation has minimal effects on 19-nor-DOC. This study sought to determine if ANG II inhibition would decrease 19-nor-DOC production. Six
Emmanuelle Charafe-Jauffret et al.
International journal of cancer, 121(8), 1779-1785 (2007-06-28)
Basal breast cancers (BBCs) have a high risk of metastasis, recurrence and death. Formal subtype definition relies on gene expression but can be approximated by protein expression. New markers are needed to help in the management of the basal subtype
Rongqin Ren et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 34(2), 438-444 (2020-08-15)
Diagnostic testing of pancreatic cyst fluid obtained by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has traditionally utilized elevated carcinoembryonic antigen (CEA) (≥192 ng/ml) and cytomorphologic examination to differentiate premalignant mucinous from benign pancreatic cystic lesions (PCLs). Molecular testing for KRAS/GNAS mutations
P A Deddish et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(16), 7807-7811 (1994-08-02)
Angiotensin I-converting enzyme (ACE, kininase II) is a single-chain protein containing two active site domains (named N- and C-domains according to position in the chain). ACE is bound to plasma membranes by its C-terminal hydrophobic transmembrane anchor. Ileal fluid, rich
Hideo Amano et al.
Heart and vessels, 34(7), 1076-1085 (2019-01-06)
Irregular protrusion on optical coherence tomography (OCT) is associated with clinical events and target lesion revascularization. We investigated clinical and procedure characteristics, plaque characteristics, slow flow after stent implantation, and clinical outcomes with irregular protrusion using OCT. Eighty-four lesions in
Carina Eklund et al.
Journal of clinical microbiology, 50(7), 2289-2298 (2012-04-27)
Accurate and internationally comparable human papillomavirus (HPV) DNA genotyping is essential both for evaluation of HPV vaccines and for effective monitoring and implementation of vaccination programs. The World Health Organization (WHO) HPV Laboratory Network (LabNet) regularly issues international proficiency studies.
Hai-Long Xie et al.
World journal of gastroenterology, 10(8), 1125-1131 (2004-04-08)
To investigate the relationship between expression of p21(WAF1) and p53 gene, and to evaluate the deletion and polymorphism of p21(WAF1) gene in gastric carcinoma (GC). Expression of p21 and p53 proteins, and deletion and polymorphism of p21 gene in GC
Vincenzo Musolino et al.
ESC heart failure, 6(1), 89-97 (2018-10-28)
Cachexia is a severe consequence of cancer. Although cancer-induced heart atrophy leads to cardiac dysfunction and heart failure (HF), biomarkers for their diagnosis have not been identified. Neutrophil gelatinase-associated lipocalin (NGAL) is an aldosterone-responsive gene increased in HF. We studied
Alec L E Butenas et al.
Experimental physiology, 105(11), 1840-1854 (2020-09-22)
What is the central question of this study? Do endoperoxide 4 and thromboxane A2 receptors, which are receptors for cyclooxygenase products of arachidonic metabolism, on thin fibre muscle afferents play a role in the chronic mechanoreflex sensitization present in rats
Andrew Howman et al.
Lancet (London, England), 381(9868), 744-751 (2013-01-15)
Membranous nephropathy leads to end-stage renal disease in more than 20% of patients. Although immunosuppressive therapy benefits some patients, trial evidence for the subset of patients with declining renal function is not available. We aimed to assess whether immunosuppression preserves
Luca Gianni et al.
The Lancet. Oncology, 13(1), 25-32 (2011-12-14)
Studies with pertuzumab, a novel anti-HER2 antibody, show improved efficacy when combined with the established HER2-directed antibody trastuzumab in breast cancer therapy. We investigated the combination of pertuzumab or trastuzumab, or both, with docetaxel and the combination of pertuzumab and
Pia R Kamstrup et al.
JAMA, 301(22), 2331-2339 (2009-06-11)
High levels of lipoprotein(a) are associated with increased risk of myocardial infarction (MI). To assess whether genetic data are consistent with this association being causal. Three studies of white individuals from Copenhagen, Denmark, were used: the Copenhagen City Heart Study
Gunter von Minckwitz et al.
The Lancet. Oncology, 15(7), 747-756 (2014-05-06)
Preclinical data suggest that triple-negative breast cancers are sensitive to interstrand crosslinking agents, and that synergy may exist for the combination of a taxane, trastuzumab, and a platinum salt for HER2-positive breast cancer. We therefore aimed to assess the efficacy
Matt R Johnson et al.
Lasers in surgery and medicine, 47(10), 839-851 (2015-09-29)
Ligamentum flavum (LF) is a tough, rubbery connective tissue providing a portion of the ligamentous stability to the spinal column, and in its hypertrophied state forms a significant compressive pathology in degenerative spinal stenosis. The interaction of lasers and this
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