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C Orskov et al.
The Journal of biological chemistry, 264(22), 12826-12829 (1989-08-05)
In the small intestine, proglucagon is processed into the previously characterized peptide "glicentin" (proglucagon (PG) 1-69) and two smaller peptides showing about 50% homology with glucagon: glucagon-like peptide-1 and -2. It was assumed that the sites of post-translational cleavage in
Li-Wei Dong et al.
Autophagy, 7(10), 1222-1229 (2011-06-10)
Autophagy enables cells to recycle long-lived proteins or damaged organelles. Beclin 1 plays important roles in autophagy, differentiation, apoptosis and the development and progression of cancer, but the expression of Beclin 1 and its possible role in primary intrahepatic cholangiocarcinoma
Li-Wei Dong et al.
Autophagy, 7(10), 1222-1229 (2011-06-10)
Autophagy enables cells to recycle long-lived proteins or damaged organelles. Beclin 1 plays important roles in autophagy, differentiation, apoptosis and the development and progression of cancer, but the expression of Beclin 1 and its possible role in primary intrahepatic cholangiocarcinoma
H J Lee et al.
Biochimica et biophysica acta, 1493(1-2), 273-278 (2000-09-09)
The full-length cDNA encoding aminopeptidase A (APAL) was cloned from a rat hippocampus cDNA library. A short variant aminopeptidase A (APAS), produced by deletion, was also cloned. In the case of APAL, the longest open reading frame encodes 945 amino
Qi-Lin Lu et al.
Carbohydrate polymers, 254, 117310-117310 (2020-12-29)
Aminated cellulose nanofibers (A-CNF) with high thermostability (>350 ℃), high crystallinity (81.25 %), and high dispersion stability were extracted from "biological grinding" biomass through one-pot microwave-hydrothermal synthesis. Worm-eaten wood powder (WWP) as the product of "biological grinding" by borers is
Akhtar Ali et al.
Genetic testing and molecular biomarkers, 13(3), 355-360 (2009-05-08)
To determine the association of three SNPs, IRF6 G820A, MTHFR C677T, and MTHFR A1298C, with nonsyndromic cleft lip with or without cleft palate (NSCL/P) in an Indian population. A total of 323 NSCL/P patients, 116 of their mothers, 108 of
Libia A Chaparro-Torres et al.
Journal of the science of food and agriculture, 96(7), 2352-2365 (2015-07-28)
Melon aroma volatiles were extracted at harvest from juice of a climacteric near-isogenic line (NIL) SC3-5-1 with two quantitative trait loci (QTLs) introgressed which produced climacteric behaviour and its non-climacteric parental (PS) using two methodologies of analysis: static headspace solid
Reza Akramipour et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1012-1013, 162-168 (2016-02-02)
The counter current salting-out homogenous liquid-liquid extraction (CCSHLLE) joined with the dispersive liquid-liquid microextraction based on solidification of floating organic drop (DLLME-SFO) has been developed as a high preconcentration technique for the determination of different drugs in urine samples. Amphetamines
G J Arlaud et al.
The Biochemical journal, 241(3), 711-720 (1987-02-01)
The amino acid sequence of human C1r A chain was determined, from sequence analysis performed on fragments obtained from C1r autolytic cleavage, cleavage of methionyl bonds, tryptic cleavages at arginine and lysine residues, and cleavages by staphylococcal proteinase. The polypeptide
Wei Zhang et al.
British journal of clinical pharmacology, 62(5), 567-572 (2006-06-27)
Nateglinide is a meglitinide analogue with antidiabetic action. A recent study showed that SLCO1B1 (which codes the OATP1B1 gene, also known as OATP-C, OATP2) is a major determinant which markedly affects the pharmacokinetics of repaglinide. Our objective was to assess
Matthew S Landis et al.
The Science of the total environment, 666, 540-558 (2019-02-26)
A comprehensive filter-based particulate matter polycyclic aromatic hydrocarbon (PAH) source apportionment study was conducted at the Wood Buffalo Environmental Association Bertha Ganter-Fort McKay (BGFM) community monitoring station from 2014 to 2015 to quantify ambient concentrations and identify major sources. The
A Benshushan et al.
Fertility and sterility, 59(5), 1065-1069 (1993-05-01)
To examine the effect of GnRH analogue (GnRH-a) on the quality of frozen-thawed embryos and the pregnancy rate (PR) resulting from transfer. A retrospective study of two groups of women undergoing transfers of frozen-thawed embryos. In group 1 ovulation induction
Iraj Saadat et al.
Molecular vision, 18, 1996-2000 (2012-08-10)
To investigate whether genetic polymorphisms of glutathione S-transferases (GSTM1, GSTT1, and GSTO2) in relation to the work place contribute to the development of cataract. The present case-control study consisted of 186 patients (108 females, 78 males) with cataract and 195
Birsen Can Demirdöğen et al.
Clinical biochemistry, 41(1-2), 1-9 (2007-10-09)
In recent years, importance of enzyme activity measurements, in addition to genotyping, in epidemiological studies relating paraoxonase 1 (PON1) and vascular disease was emphasized. This is the first report evaluating paraoxonase and arylesterase activities as risk factors for ischemic stroke.
Julien Textoris et al.
Critical care (London, England), 16(4), R120-R120 (2012-07-12)
Hypoxia-inducible factor-1 (HIF1) controls the expression of genes involved in the cellular response to hypoxia. No information is available on its expression in critically ill patients. Thus, we designed the first clinical study in order to evaluate the role of
S Mobashery et al.
The Journal of biological chemistry, 261(17), 7879-7887 (1986-06-15)
Two novel C10-(dipeptidyl)cephalosporin esters (3-(beta-chloro-L-alanyl-beta-chloro-L-alanyloxymethyl)-7 beta-(2-thienylacetamido)-3-cephem-4-carboxylic acid (7) and sodium 3-(L-alanyl-L-alanyloxymethyl)-7 beta-(2-thienylacetamido)-3-cephem-4-carboxylate, toluene-sulfonic acid salt (18] were synthesized, and their reactions with Escherichia coli TEM beta-lactamase were examined. Kinetic parameters determined for the enzymatic reactions of 7 (Km = 0.32
P J Norman et al.
Genes and immunity, 3(2), 86-95 (2002-04-18)
Natural killer (NK) and some T cells express killer cell immunoglobulin-like receptors (KIRs), which interact with HLA class I expressed by target cells and consequently regulate cytolytic activity. The number of KIR loci can vary and so a range of
Daisuke Nonaka et al.
The American journal of surgical pathology, 32(10), 1566-1571 (2008-08-30)
The ovary is a common site of involvement for metastasis and the breast is one of the most common sources. Metastatic breast carcinoma can mimic a primary ovarian carcinoma. Pax8 is a crucial transcription factor for organogenesis of the thyroid
Liang Qi et al.
Talanta, 209, 120523-120523 (2020-01-02)
DNA adducts usually occur at a level of 0.1-1 adducts per 108 unmodified DNA bases, which can cause many adverse health effects if not normally repaired. Using microgram amounts of DNA to detect DNA adducts remains challenging due to the
Eugenia Flores-Alfaro et al.
Circulation journal : official journal of the Japanese Circulation Society, 72(7), 1170-1174 (2008-06-26)
Previous studies have reported elevated levels of C-reactive protein (CRP) in obese and diabetic subjects, but it is unclear whether both these conditions have an additive effect on the variability of serum CRP levels. The study enrolled 385 men and
T Shimizu et al.
Helicobacter, 1(4), 197-206 (1996-12-01)
Attempts have been made to develop an accurate method for detecting Helicobacter pylori in histological sections. Biopsy specimens were obtained from the stomachs of 167 patients with gastric ulcer (33), duodenal ulcer (52), gastroduodenal ulcer (15), chronic gastritis (45), and
Go Kuwata et al.
Journal of cancer research and clinical oncology, 139(6), 925-932 (2013-02-28)
N (1),N (12)-Diacetylspermine (DiAcSpm) is a tumor marker featured by increase in the urine of patients with cancers, including early colorectal cancer, but where and how DiAcSpm is made remains unclear. We aimed to clarify whether colorectal cancer tissues produce
Karen Huen et al.
Toxicology and applied pharmacology, 244(2), 181-189 (2010-01-05)
The paraoxonase 1 (PON1) enzyme prevents low-density lipoprotein oxidation and also detoxifies the oxon derivatives of certain neurotoxic organophosphate (OP) pesticides. PON1 activity in infants is low compared to adults, rendering them with lower metabolic and antioxidant capacities. We made
Hauh-Jyun Candy Chen et al.
Analytical chemistry, 81(23), 9812-9818 (2009-11-11)
Humans are exposed to acrolein and crotonaldehyde due to environmental pollution and endogenous lipid peroxidation. These aldehydes react with the 2'-deoxyguanosine moiety of DNA, forming the exocyclic 1,N2-propano-2'-deoxyguanosine adducts AdG and CdG. These adducts are mutagenic lesions, and they play
Gabriela Vera-Lozada et al.
Oncoimmunology, 7(5), e1389821-e1389821 (2018-05-04)
Interleukin-10 (IL10) is an immune regulatory cytokine. Single nucleotide polymorphisms (SNPs) in IL10 promoter have been associated with prognosis in adult classical Hodgkin lymphoma (cHL). We analyzed IL10 SNPs -1082 and -592 in respect of therapy response, gene expression and
Milton D Chiang et al.
Antioxidants (Basel, Switzerland), 11(4) (2022-04-24)
Endoplasmic reticulum (ER) stress mediates the effects of obesity on aggravating sepsis-induced lung injury. We investigated whether exosomes from human placenta choriodecidual membrane-derived mesenchymal stem cells (pcMSCs) can mitigate pulmonary ER stress, lung injury, and the mechanisms of inflammation, oxidation
Kenneth V I Rolston et al.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 22(1), 7-14 (2013-08-27)
The goal of this study was to describe the outcomes associated with daptomycin treatment of documented gram-positive infections in patients with neutropenia. All patients with neutropenia (≤500 cells/m(3)) and at least one documented gram-positive culture from 2006-2009 were identified from
Piotr J Slomka et al.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 22(6), 1285-1295 (2015-02-24)
We aimed to evaluate the utility of fully automated software registration intended to improve CT attenuation correction (CTAC) map misalignments during cardiac (82)Rb PET/CT myocardial perfusion imaging (MPI). 171 consecutive patients (108 males, mean age 69 years), undergoing both rest-stress
Andrew Howman et al.
Lancet (London, England), 381(9868), 744-751 (2013-01-15)
Membranous nephropathy leads to end-stage renal disease in more than 20% of patients. Although immunosuppressive therapy benefits some patients, trial evidence for the subset of patients with declining renal function is not available. We aimed to assess whether immunosuppression preserves
Mohammad Salem et al.
Clinical and translational gastroenterology, 6, e122-e122 (2015-12-18)
Autophagy-related 16-like 1 (ATG16L1) deficiency leads to impaired cellular autophagy and bacterial degradation as well as an altered cytokine production. The single-nucleotide polymorphism rs2241880 (T300A) is associated with an increased risk for Crohn's disease (CD). ATG16L1 polymorphisms could therefore have
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