109-12-6

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Genomic analysis of clinical samples with serologic ABO blood grouping discrepancies: identification of 15 novel A and B subgroup alleles.

M L Olsson et al.

Blood, 98(5), 1585-1593 (2001-08-25)

Since the cloning in 1990 of complementary DNA corresponding to messenger RNA transcribed at the blood group ABO locus, polymorphisms and phenotype-genotype correlations have been reported by several investigators. Exons 6 and 7, constituting 77% of the gene, have been

High incidence of FXI deficiency in a Spanish town caused by 11 different mutations and the first duplication of F11: Results from the Yecla study.

J Esteban et al.

Haemophilia : the official journal of the World Federation of Hemophilia, 23(6), e488-e496 (2017-09-30)

Factor XI (FXI) deficiency is a rare disorder with molecular heterogeneity in Caucasians but relatively frequent and molecularly homogeneous in certain populations. To characterize FXI deficiency in a Spanish town of 60 000 inhabitants. A total of 324 764 APTT tests were

In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone.

J S McCune et al.

Clinical pharmacology and therapeutics, 68(4), 356-366 (2000-11-04)

The aims of these experiments were to determine the effect of a therapeutic regimen of dexamethasone on cytochrome P4503A4 (CYP3A4) activity in healthy volunteers; and the concentration-effect relationship between dexamethasone and CYP3A4 activity in primary human hepatocyte cultures. The effect

Third-Line Nivolumab Monotherapy in Recurrent SCLC: CheckMate 032.

Neal Ready et al.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 14(2), 237-244 (2018-10-14)

For patients with recurrent SCLC, topotecan remains the only approved second-line treatment, and the outcomes are poor. CheckMate 032 is a phase 1/2, multicenter, open-label study of nivolumab or nivolumab plus ipilimumab in SCLC or other advanced/metastatic solid tumors previously

Validation of web-based, multiple 24-h recalls combined with nutritional supplement intake questionnaires against nitrogen excretions to determine protein intake in Dutch elite athletes.

F C Wardenaar et al.

The British journal of nutrition, 114(12), 2083-2092 (2015-10-06)

Information on dietary composition is vitally important for elite athletes to optimise their performance and recovery, which requires valid tools. The aim of the present study was to investigate the validity of assessing protein intake using three web-based 24-h recalls

Cortisol inhibits the Escherichia coli-induced endometrial inflammatory response through NF-κB and MAPK pathways in postpartum goats.

Luying Cui et al.

Animal reproduction science, 215, 106333-106333 (2020-03-29)

Glucocorticoids have been widely used as anti-inflammatory therapies. The mechanisms of cortisol action in goat does with endometritis, however, have not been reported. The aim of this study was to investigate the mechanism of cortisol in modulation of effects of

Inhibitory Effects of Breast Milk-Derived Lactobacillus rhamnosus Probio-M9 on Colitis-Associated Carcinogenesis by Restoration of the Gut Microbiota in a Mouse Model.

Haiyan Xu et al.

Nutrients, 13(4) (2021-04-04)

Chronic inflammation is a risk factor for colorectal cancer, and inflammatory cytokines secreted from inflammatory cells and active oxygen facilitate tumorigenesis. Intestinal bacteria are thought to regulate tumorigenesis. The longer the breastfeeding period, the lower is the risk of inflammatory

Red blood cell folate vitamer distribution in healthy subjects is determined by the methylenetetrahydrofolate reductase C677T polymorphism and by the total folate status.

Yvo M Smulders et al.

The Journal of nutritional biochemistry, 18(10), 693-699 (2007-04-10)

Red blood cells (RBCs) represent a storage pool for folate. In contrast to plasma, RBC folate can appear in different biochemical isoforms. So far, only the methylenetetrahydrofolate reductase (MTHFR) 677 TT genotype has been identified as a determinant of RBC

Effect of clenbuterol on non-endothelial nitric oxide release in rat mesenteric arteries and the involvement of beta-adrenoceptors.

J Marín et al.

British journal of pharmacology, 124(3), 473-478 (1998-07-01)

1. The aim of the present study was to explore the contribution of adrenergic, sensory and nitrergic innervations to the inhibitory effects of the beta2-adrenoceptor agonist clenbuterol on responses to electrical field stimulation (EFS, 200 mA, 0.3 ms, 1-16 Hz

Melatonin Analogues Potently Inhibit MAO-B and Protect PC12 Cells against Oxidative Stress.

Ahmed Elkamhawy et al.

Antioxidants (Basel, Switzerland), 10(10) (2021-10-24)

Monoamine oxidase B (MAO-B) metabolizes dopamine and plays an important role in oxidative stress by altering the redox state of neuronal and glial cells. MAO-B inhibitors are a promising therapeutical approach for Parkinson's disease (PD). Herein, 24 melatonin analogues (3a-x)

Cardiovascular phenotype of a mouse strain with disruption of bradykinin B2-receptor gene.

P Madeddu et al.

Circulation, 96(10), 3570-3578 (1997-12-13)

To evaluate the role of kinins in the regulation of cardiovascular function, we studied the phenotype of a mouse strain with disruption of the bradykinin B2-receptor gene (Bk 2r-/-). Under basal conditions, tail-cuff blood pressure was higher in Bk2r-/- than

Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain.

Laura Calatayud et al.

Antimicrobial agents and chemotherapy, 51(9), 3240-3246 (2007-07-04)

The aim of this study was to analyze the distributions of antibiotic susceptibility patterns, serotypes, phenotypes, genotypes, and macrolide resistance genes among 125 nonduplicated erythromycin-resistant Streptococcus pneumoniae clinical isolates collected in a Spanish point prevalence study. The prevalence of resistance

The reaction of cytochromes c and c2 with the Rhodospirillum rubrum reaction center involves the heme crevice domain.

J Hall et al.

The Journal of biological chemistry, 262(23), 11046-11051 (1987-08-15)

In order to define the interaction domain on Rhodospirillum rubrum cytochrome c2 for the photosynthetic reaction center, positively charged lysine amino groups on cytochrome c2 were modified to form negatively charged carboxydinitrophenyl lysines. The reaction mixture was separated into six

FadA promotes DNA damage and progression of Fusobacterium nucleatum-induced colorectal cancer through up-regulation of chk2.

Pin Guo et al.

Journal of experimental & clinical cancer research : CR, 39(1), 202-202 (2020-10-01)

Globally, colorectal cancer (CRC) affects more than 1 million people each year. In addition to non-modifiable and other environmental risk factors, Fusobacterium nucleatum infection has been linked to CRC recently. In this study, we explored mechanisms underlying the role of

Intranasal triamcinolone and growth velocity.

David P Skoner et al.

Pediatrics, 135(2), e348-e356 (2015-01-28)

Inadequate designs and conflicting results from previous studies prompted the US Food and Drug Administration to publish guidelines for the design of clinical trials evaluating the effects of orally inhaled and intranasal corticosteroids on the growth of children. This study

Prolonged release oxycodone-naloxone for treatment of severe restless legs syndrome after failure of previous treatment: a double-blind, randomised, placebo-controlled trial with an open-label extension.

Claudia Trenkwalder et al.

The Lancet. Neurology, 12(12), 1141-1150 (2013-10-22)

Opioids are a potential new treatment for severe restless legs syndrome. We investigated the efficacy and safety of a fixed-dose combination of prolonged release oxycodone-naloxone for patients with severe restless legs syndrome inadequately controlled by previous, mainly dopaminergic, treatment. This

Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors.

Roeland F de Wilde et al.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 25(7), 1033-1039 (2012-05-12)

Approximately 45% of sporadic well-differentiated pancreatic neuroendocrine tumors harbor mutations in either ATRX (alpha thalassemia/mental retardation X-linked) or DAXX (death domain-associated protein). These novel tumor suppressor genes encode nuclear proteins that interact with one another and function in chromatin remodeling

A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial.

Kirsten E Bell et al.

PloS one, 12(7), e0181387-e0181387 (2017-07-19)

Protein and other compounds can exert anabolic effects on skeletal muscle, particularly in conjunction with exercise. The objective of this study was to evaluate the efficacy of twice daily consumption of a protein-based, multi-ingredient nutritional supplement to increase strength and

Intramolecular charge transfer and dielectric solvent relaxation in n-propyl cyanide. N-phenylpyrrole and 4-dimethylamino-4'-cyanostilbene.

Sergey I Druzhinin et al.

The journal of physical chemistry. A, 110(47), 12760-12768 (2006-11-28)

Fast intramolecular charge transfer (ICT) accompanied by dual fluorescence from a locally excited (LE) and an ICT state taking place with N-phenylpyrrole (PP) in the solvent n-propyl cyanide (PrCN) is investigated as a function of temperature between 25 and -112

Clinical and biochemical phenotype of familial anterior hypopituitarism from mutation of the PROP1 gene.

A L Rosenbloom et al.

The Journal of clinical endocrinology and metabolism, 84(1), 50-57 (1999-01-27)

We have investigated the largest family with PROP1 deficiency reported to date. Eight patients, aged 17-40 yr, in two sibships with possibly related mothers but no parental consanguinity were 109-137 cm in height (-8.8 to [minus]5.9 SD score) and sexually

Identification of new biomarkers for Acute Respiratory Distress Syndrome by expression-based genome-wide association study.

Dmitry N Grigoryev et al.

BMC pulmonary medicine, 15, 95-95 (2015-08-20)

Accumulated to-date gene microarray data on Acute Respiratory Distress Syndrome (ARDS) in the Gene Expression Omnibus (GEO) represent a rich source for identifying new unsuspected targets and mechanisms of ARDS. The recently developed expression-based genome-wide association study (eGWAS) for analysis

Influence of time under mechanical ventilation on bronchopulmonary dysplasia severity in extremely preterm infants: a pilot study.

Victoria Escobar et al.

BMC pediatrics, 20(1), 241-241 (2020-05-23)

The relation between mechanical ventilation (MV) and bronchopulmonary dysplasia (BPD) - a common disease in extremely premature newborn (PTNB) - is well stabilished, but is unknown, however, how much time under MV influences the severity of the disease. To define

Expression of deoxycytidine kinase and phosphorylation of 2-chlorodeoxyadenosine in human normal and tumour cells and tissues.

T Spasokoukotskaja et al.

European journal of cancer (Oxford, England : 1990), 31A(2), 202-208 (1995-01-01)

Deoxycytidine kinase (dCK) activates several clinically important drugs, including the recently developed antileukaemic compound 2-chlorodeoxyadenosine (CdA). The distribution of dCK in cells and tissues has previously been determined by activity measurements, which may be unreliable because of the presence of

Influence of endothelin receptor antagonism on smooth muscle cell proliferation after chronic renal failure.

Gabriele Sauter et al.

Journal of cardiovascular pharmacology, 44 Suppl 1, S165-S167 (2005-04-20)

Uremic patients suffer from an accelerated development of atherosclerosis. In uremia the angiotensin-aldosterone-endothelin system is activated. It is not known, however, whether endothelin receptor antagonism inhibits atherosclerosis in uremia. An experimental model of mild renal insufficiency is subtotal nephrectomy in

Control of myocardial oxygen consumption in transgenic mice overexpressing vascular eNOS.

E K Walsh et al.

American journal of physiology. Heart and circulatory physiology, 287(5), H2115-H2121 (2004-07-31)

Our objective was to investigate the potential role of selective endothelial nitric oxide (NO) synthase (eNOS) overexpression in coronary blood vessels in the control of myocardial oxygen consumption (MVO2). Transgenic (Tg) eNOS-overexpressing mice (eNOS Tg) (n=22) and wild-type (WT) mice

The guanosine-adenosine interaction exists in vivo.

Edwin K Jackson et al.

The Journal of pharmacology and experimental therapeutics, 350(3), 719-726 (2014-07-09)

In cultured renal cells and isolated perfused kidneys, extracellular guanosine augments extracellular adenosine and inosine (the major renal metabolite of adenosine) levels by altering the extracellular disposition of these purines. The present study addressed whether this "guanosine-adenosine mechanism" exists in

Blocking RAGE expression after injury reduces inflammation in mouse model of acute lung injury.

Lynne L Johnson et al.

Respiratory research, 24(1), 21-21 (2023-01-21)

Receptor for Advanced Glycated Endproducts (RAGE) plays a major role in the inflammatory response to infectious and toxin induced acute lung injury. We tested the hypothesis that a RAGE blocking antibody when administered after the onset of injury can reduce

Docetaxel and prednisone with or without lenalidomide in chemotherapy-naive patients with metastatic castration-resistant prostate cancer (MAINSAIL): a randomised, double-blind, placebo-controlled phase 3 trial.

Daniel P Petrylak et al.

The Lancet. Oncology, 16(4), 417-425 (2015-03-07)

Patients with metastatic castration-resistant prostate cancer have few treatment options. We investigated the safety and efficacy of lenalidomide, an immunomodulatory agent with anti-angiogenic properties, in combination with docetaxel and prednisone in chemotherapy-naive patients with metastatic castration-resistant prostate cancer. In this

U-73122, an aminosteroid phospholipase C antagonist, noncompetitively inhibits thyrotropin-releasing hormone effects in GH3 rat pituitary cells.

R C Smallridge et al.

Endocrinology, 131(4), 1883-1888 (1992-10-01)

TRH increases cytosolic-free calcium ([Ca2+]i) by activating phospholipase C(PL-C), which induces phosphoinositol hydrolysis, leading to Ca2+ mobilization from inositol trisphosphate (IP3) sensitive stores, and by increasing Ca2+ influx. Increases in [Ca2+]i stimulate PRL secretion. We investigated the effects of U-73122

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18-59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial.

Yanjun Zhang et al.

The Lancet. Infectious diseases, 21(2), 181-192 (2020-11-21)

With the unprecedented morbidity and mortality associated with the COVID-19 pandemic, a vaccine against COVID-19 is urgently needed. We investigated CoronaVac (Sinovac Life Sciences, Beijing, China), an inactivated vaccine candidate against COVID-19, containing inactivated severe acute respiratory syndrome coronavirus 2

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